ID   A0A3P8RZ50_AMPPE        Unreviewed;       351 AA.
AC   A0A3P8RZ50;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   RecName: Full=tRNA N(3)-methylcytidine methyltransferase {ECO:0000256|PIRNR:PIRNR037755};
DE            EC=2.1.1.- {ECO:0000256|PIRNR:PIRNR037755};
OS   Amphiprion percula (Orange clownfish) (Lutjanus percula).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Pomacentridae; Amphiprion.
OX   NCBI_TaxID=161767 {ECO:0000313|Ensembl:ENSAPEP00000005361.1, ECO:0000313|Proteomes:UP000265080};
RN   [1] {ECO:0000313|Ensembl:ENSAPEP00000005361.1, ECO:0000313|Proteomes:UP000265080}
RP   NUCLEOTIDE SEQUENCE.
RA   Lehmann R.;
RT   "Finding Nemo's genes: A chromosome-scale reference assembly of the genome
RT   of the orange clownfish Amphiprion percula.";
RL   Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSAPEP00000005361.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: S-adenosyl-L-methionine-dependent methyltransferase.
CC       {ECO:0000256|PIRNR:PIRNR037755}.
CC   -!- SIMILARITY: Belongs to the methyltransferase superfamily. METL family.
CC       {ECO:0000256|PIRNR:PIRNR037755}.
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DR   AlphaFoldDB; A0A3P8RZ50; -.
DR   Ensembl; ENSAPET00000005501.1; ENSAPEP00000005361.1; ENSAPEG00000003799.1.
DR   GeneTree; ENSGT00940000156059; -.
DR   Proteomes; UP000265080; Chromosome 14.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   CDD; cd02440; AdoMet_MTases; 1.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   InterPro; IPR026113; METTL2/6/8-like.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   PANTHER; PTHR22809; METHYLTRANSFERASE-RELATED; 1.
DR   PANTHER; PTHR22809:SF4; TRNA N(3)-METHYLCYTIDINE METHYLTRANSFERASE METTL2A; 1.
DR   Pfam; PF13489; Methyltransf_23; 1.
DR   PIRSF; PIRSF037755; Mettl2_prd; 1.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE   3: Inferred from homology;
KW   Methyltransferase {ECO:0000256|PIRNR:PIRNR037755};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265080};
KW   Transferase {ECO:0000256|PIRNR:PIRNR037755}.
FT   REGION          1..34
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   351 AA;  40460 MW;  1B79D957CBA85B40 CRC64;
     MAAPLTVDGV DSSGGEPGLI LTDSSGGEQR RPQFGTRFLT DPRQVFQHNA WDNVEWTDEQ
     EAAAKKKVSE NNHPLPPEKQ EEYDCRANEY WNEFYTIHEN RFFKDRHWLF TEFPELAPQC
     SVNYESHPED HRDQKLCKEF ATLSHSDEEF PGSSATYHIL ELCLFRSDPG LFVYCCDFSS
     TAVELVKTNP EYDPGRCFAF VHDLSDVGAN YPVPDGSLDV IVLIFVLSAL HPNKMQESIS
     RLARLLKPGG VMLLRDYGRY DMAQLRFKKG RCLSENFYVR GDGTRVYFFT QDELNELFTE
     AGLEKVQNLV DRRLQVNRGK QLTMYRVWIQ CKYRKPLVQS SETMEDKTSS A
//