ID A0A3P8RZV7_AMPPE Unreviewed; 776 AA.
AC A0A3P8RZV7;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE SubName: Full=Protein tyrosine phosphatase receptor type Nb {ECO:0000313|Ensembl:ENSAPEP00000006198.1};
GN Name=PTPRN {ECO:0000313|Ensembl:ENSAPEP00000006198.1};
OS Amphiprion percula (Orange clownfish) (Lutjanus percula).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Amphiprion.
OX NCBI_TaxID=161767 {ECO:0000313|Ensembl:ENSAPEP00000006198.1, ECO:0000313|Proteomes:UP000265080};
RN [1] {ECO:0000313|Ensembl:ENSAPEP00000006198.1, ECO:0000313|Proteomes:UP000265080}
RP NUCLEOTIDE SEQUENCE.
RA Lehmann R.;
RT "Finding Nemo's genes: A chromosome-scale reference assembly of the genome
RT of the orange clownfish Amphiprion percula.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPEP00000006198.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle membrane
CC {ECO:0000256|ARBA:ARBA00004212}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004212}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}.
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DR AlphaFoldDB; A0A3P8RZV7; -.
DR STRING; 161767.ENSAPEP00000006198; -.
DR Ensembl; ENSAPET00000006366.1; ENSAPEP00000006198.1; ENSAPEG00000004420.1.
DR GeneTree; ENSGT00940000154095; -.
DR OMA; QDYNSQD; -.
DR Proteomes; UP000265080; Chromosome 24.
DR GO; GO:0030141; C:secretory granule; IEA:InterPro.
DR GO; GO:0045202; C:synapse; IEA:UniProtKB-KW.
DR GO; GO:0030658; C:transport vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR Gene3D; 3.30.70.2470; Protein-tyrosine phosphatase receptor IA-2 ectodomain; 1.
DR InterPro; IPR033522; IA-2/IA-2_beta.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR021613; Receptor_IA-2_dom.
DR InterPro; IPR038112; Receptor_IA-2_ectodomain_sf.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR46106; IA-2 PROTEIN TYROSINE PHOSPHATASE, ISOFORM C; 1.
DR PANTHER; PTHR46106:SF1; RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE-LIKE N; 1.
DR Pfam; PF11548; Receptor_IA-2; 1.
DR Pfam; PF00102; Y_phosphatase; 1.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00194; PTPc; 1.
DR SMART; SM00404; PTPc_motif; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 1.
PE 4: Predicted;
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000265080};
KW Synapse {ECO:0000256|ARBA:ARBA00023018};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 410..434
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 506..766
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 685..757
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 151..181
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 293..315
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 776 AA; 85796 MW; 704AFD46F2743230 CRC64;
MGQTGQASPH SYGLFGQCQD PQQEPVQYQV SVPVLHKLQE VLKDLMVQGE SMNTSCSVCF
TCRSSRLMGP QKVKGPDDPD RMQQYLDYMV LDPSRSSVHM QTPLLDPYSF HKVQGGLSLG
GFAGFPSFPS SRSRTRGSPF GPDRQLLGTC CPFTSPSPSS SSSSSPHRGP AAGLPSSSSS
SSFFPDLDFP LDYGEDFVSQ MSEQPEEAEK KAEKEYDALS GLDERSLQRL ALLLDHYGLD
MKDLSPEQMN NLPAALKQLQ MENSYGYKQS KDKYGNNAAT GKKVTEGSMA YKMAAQQAPP
STAKPQGSVK EATPSEAAKL DKLGQEQPVD QQKEFGYIVA NQSVVGPSIT FRIRPNSKNL
TAADVAEKAV AEKNFLESET GLKVLQSGVG EKNDAKALPL ATRVQPGSRW VFATLVAMAC
IGGILVAAMT VACLRHHAHR LAAKKLGLGP EGGSFSHQEY QLSPVPVHTA AHPSWCEEPA
QANMDISTGH MILAYMEDHL RNKDRLMKEW EALCSYQAEP SAVSMAQSDA NVKKNRCPDS
VPYDHSRVKL KAEINPSRMD YINASTIIEH DPRMPAYIAT QGPLSHTISD FWQMVWENGC
TVIVMMTALV EDGEKQCDRY WPDEGSSLYH IYEVNLVSEH IWCNDFLVRS FYLKNVQTQE
TRTLTQFHFL SWPAQGIPTS TRPLLDFRRK VNKCYRGRSC PIIVHCSDGT GRTGTYILID
MVLNRMAKGV KEIDIAATLE HVRDQRPGMV RTKDQFEFAL TAVAEEVNAI LKALPQ
//
