ID   A0A3P8RZY1_AMPPE        Unreviewed;       603 AA.
AC   A0A3P8RZY1;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   24-JAN-2024, entry version 20.
DE   SubName: Full=FERM domain containing 3 {ECO:0000313|Ensembl:ENSAPEP00000004789.1};
GN   Name=FRMD3 {ECO:0000313|Ensembl:ENSAPEP00000004789.1};
OS   Amphiprion percula (Orange clownfish) (Lutjanus percula).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Pomacentridae; Amphiprion.
OX   NCBI_TaxID=161767 {ECO:0000313|Ensembl:ENSAPEP00000004789.1, ECO:0000313|Proteomes:UP000265080};
RN   [1] {ECO:0000313|Ensembl:ENSAPEP00000004789.1, ECO:0000313|Proteomes:UP000265080}
RP   NUCLEOTIDE SEQUENCE.
RA   Lehmann R.;
RT   "Finding Nemo's genes: A chromosome-scale reference assembly of the genome
RT   of the orange clownfish Amphiprion percula.";
RL   Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSAPEP00000004789.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A3P8RZY1; -.
DR   STRING; 161767.ENSAPEP00000004789; -.
DR   Ensembl; ENSAPET00000004914.1; ENSAPEP00000004789.1; ENSAPEG00000003415.1.
DR   GeneTree; ENSGT00940000158577; -.
DR   OMA; CPLRQWM; -.
DR   Proteomes; UP000265080; Chromosome 5.
DR   GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008092; F:cytoskeletal protein binding; IEA:InterPro.
DR   CDD; cd14473; FERM_B-lobe; 1.
DR   CDD; cd17102; FERM_F1_FRMD3; 1.
DR   Gene3D; 1.20.80.10; -; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR019749; Band_41_domain.
DR   InterPro; IPR000798; Ez/rad/moesin-like.
DR   InterPro; IPR014847; FA.
DR   InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR   InterPro; IPR035963; FERM_2.
DR   InterPro; IPR019748; FERM_central.
DR   InterPro; IPR019747; FERM_CS.
DR   InterPro; IPR000299; FERM_domain.
DR   InterPro; IPR018979; FERM_N.
DR   InterPro; IPR018980; FERM_PH-like_C.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   PANTHER; PTHR23280; 4.1 G PROTEIN; 1.
DR   PANTHER; PTHR23280:SF8; FERM DOMAIN-CONTAINING PROTEIN 3; 1.
DR   Pfam; PF08736; FA; 1.
DR   Pfam; PF09380; FERM_C; 1.
DR   Pfam; PF00373; FERM_M; 1.
DR   Pfam; PF09379; FERM_N; 1.
DR   PRINTS; PR00935; BAND41.
DR   PRINTS; PR00661; ERMFAMILY.
DR   SMART; SM00295; B41; 1.
DR   SMART; SM01195; FA; 1.
DR   SMART; SM01196; FERM_C; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   SUPFAM; SSF47031; Second domain of FERM; 1.
DR   SUPFAM; SSF54236; Ubiquitin-like; 1.
DR   PROSITE; PS00660; FERM_1; 1.
DR   PROSITE; PS50057; FERM_3; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265080};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        538..560
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          32..312
FT                   /note="FERM"
FT                   /evidence="ECO:0000259|PROSITE:PS50057"
FT   REGION          387..442
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        387..401
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        422..436
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   603 AA;  69315 MW;  69A025E20774E98F CRC64;
     TSLSCFSETR TDRRMKMLRF RSPSIRSLDQ EILCTIRLLD DSEISCSIQR DTKGQFLLDH
     VCNHYNLLEK DYFGIRYVDP EKQRHWLEPN KPVVRQMKSQ QPYTMCFRVK FYPHEPMKIK
     EELTRYLLYL QLKRDIYHGR LLCPFAEAAY LGACIIQAEL GDYDPEEHPS DYIRDFKLFP
     KQSLKLERKI MEIHKNELRG QCAALAELNM LQRAHSLETY GVDPHPCKDF TGSTAFLGFT
     ATGFVVFQGN KRIHLLKWAD VSKLKFEGKT FYVIGIQKEK KLVLTFHTST PAACKHLWKC
     GVENQAFYKC AKSSQIKTVS SSNIFFKGSR FRYSGRVAKE VIEASSKILR EPPEVRRYGQ
     SRSYNSLSHK NLIMNMEPLV PALPSTNEYE ETQQSPDGGN SALGVDLQPP RVSMETSNLR
     PQTPKPEDRL EEDDESSGPL TISELTYSPC ASMLPTPVDD GQGGVDLIFS SPVQSPARLL
     RELHADPDIQ AQLEAERERD RAYERTRQAA RSRMSGVLTS SLRLLSSNER VNACVLSMAR
     FIAVVMGVLL VTVPMLLLLL ESDIDVSFLH EIRQTPEFEQ FHYEYYCPLR RWILYRLGCL
     DPS
//