ID A0A3P8S1U4_AMPPE Unreviewed; 1368 AA.
AC A0A3P8S1U4;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE SubName: Full=EvC ciliary complex subunit 2 {ECO:0000313|Ensembl:ENSAPEP00000005519.1};
GN Name=EVC2 {ECO:0000313|Ensembl:ENSAPEP00000005519.1};
OS Amphiprion percula (Orange clownfish) (Lutjanus percula).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Amphiprion.
OX NCBI_TaxID=161767 {ECO:0000313|Ensembl:ENSAPEP00000005519.1, ECO:0000313|Proteomes:UP000265080};
RN [1] {ECO:0000313|Ensembl:ENSAPEP00000005519.1, ECO:0000313|Proteomes:UP000265080}
RP NUCLEOTIDE SEQUENCE.
RA Lehmann R.;
RT "Finding Nemo's genes: A chromosome-scale reference assembly of the genome
RT of the orange clownfish Amphiprion percula.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPEP00000005519.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium membrane
CC {ECO:0000256|ARBA:ARBA00004309}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}.
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DR STRING; 161767.ENSAPEP00000005519; -.
DR Ensembl; ENSAPET00000005663.1; ENSAPEP00000005519.1; ENSAPEG00000003882.1.
DR GeneTree; ENSGT00940000154127; -.
DR OMA; IFFAQIK; -.
DR Proteomes; UP000265080; Chromosome 6.
DR GO; GO:0060170; C:ciliary membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.
DR GO; GO:0007224; P:smoothened signaling pathway; IEA:InterPro.
DR InterPro; IPR022076; Limbin.
DR InterPro; IPR026501; Limbin/EVC.
DR PANTHER; PTHR16795:SF14; LIMBIN; 1.
DR PANTHER; PTHR16795; LIMBIN/ELLIS-VAN CREVELD PROTEIN; 1.
DR Pfam; PF12297; EVC2_like; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000265080};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..30
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 305..331
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 1054..1079
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 819..846
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1368 AA; 154326 MW; F622E26B7DF56B51 CRC64;
MLRVHFVVER LTIWSLLLNI HVLCTFPSYL CVLCCHDVTR RTGAAEDGAG RQPCSNCSSV
DTSWHTTPPS LPLDHGSLAM QNDPGWKSAD LTLLRMDGTM EINGPLGFYG GRLLSSSAPA
GPWGHSFYSS FTYMSNILHL RNRRRSILTR YSPGLSLPQV QSVAPPSAFG VRFHKCAQVK
LDTDPPQLIF FLLIHNMGPV GGTNLSQVAI RDSISGIVPV KTEGRVVESG YQTFAIDSLQ
AGSQVVVNYT AHVRNHKNEV LDLPAFLTFS NASQNDVSMF GPLTANLTLR VNSTDRIYPN
HGVHFAGFVA GFFVTLVLLS LGFLAMNLIG LRTRLSLLQQ RRNRGDSDAE YADCNLSEAV
KDEASFEDKM VDIMVLEDPQ NMYQALENLE MSTLLHATNN LEATRIQIYK DVMSSLLGGL
RSRGQASAQS QQRLLSVLHG QLLGMEGRLK EERGARMAAL AGQCNLETRE EMEAEHRREA
AEKAQAELLC QHADQQELLQ CSVLLEKLHK LSQSRLQRIL LVRHEEASAK VQRQIIEWRR
VELHKIFSEE LEEATRMGEL EKSTAKSLQH DYFTCQDQLE EVLDVVLANQ RYVLSERSAQ
RKFLVHSLHS LNGLISDTFS STSSNLDSWF THIRRGSTVP AEQIDQLQEK SQKELVMLRQ
RLDEALNQER RAMRCGLIKK RRELISDMVR MHKQRQRDLS GMSKGLEERI EIAQHLRCWQ
NLLTAHSLEL AELINNLDEE AAADIRKVTM RVIQGAIADV KAIQPSAAQA MLTLLPPGEQ
RSLLQVEPDP AAGVQASGQG ASALLQGQER LHQEGKAALR TLSCTREALQ EAMEKELQEQ
KELRADCRDF FRRLCLAQLT LSEDDRLRMK LEFQKCLSVI DCCLMLPHAV SRRKLHAALT
AWRKEREKHM TYTQSKGKTS EARLKTDTSD LRLFQKRLED GIQLFEKEKE METGVMDKVL
EEMQREREND LRCQADGLAM QMATIHYQKA ERRSKVLETS RTMVTLHGLL IQQLRERKNL
ERQDMAQSIQ SHCLGLEEAE QQLQKERSEL DSLLASQPRV ESSKGHQEDS DATEEDSEEG
NVFQLQLDCR MTFILQEAFC KCEQVITLMA ERFQAMTANN QALEEIKEQM ELKRLYANCD
QDLEFASQLV KQSQMSAEVL LEALRLFLPT LPESELLSIT DALCPKQHPV AASAEQEHSG
CAGESNRVLL VKLREDVVQK NMLNMSSCAV ERGRLQEKRQ SLMEKLLPRS RLLLPRDAAP
LLVEEKRKQD SFTKAQLPIY KSTLPVKQQQ SDGAKDRVVD TVNAALHGTA EEAMASACSA
LGSAATGERL FVFRDPPESC DTMDVPKRKR KRNFLNLKKG SVAPTNLP
//