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Database: UniProt
Entry: A0A3P8S2Q4_AMPPE
LinkDB: A0A3P8S2Q4_AMPPE
Original site: A0A3P8S2Q4_AMPPE 
ID   A0A3P8S2Q4_AMPPE        Unreviewed;      1487 AA.
AC   A0A3P8S2Q4;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   24-JAN-2024, entry version 21.
DE   RecName: Full=Alpha-2-macroglobulin-like {ECO:0008006|Google:ProtNLM};
OS   Amphiprion percula (Orange clownfish) (Lutjanus percula).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Pomacentridae; Amphiprion.
OX   NCBI_TaxID=161767 {ECO:0000313|Ensembl:ENSAPEP00000006325.1, ECO:0000313|Proteomes:UP000265080};
RN   [1] {ECO:0000313|Ensembl:ENSAPEP00000006325.1, ECO:0000313|Proteomes:UP000265080}
RP   NUCLEOTIDE SEQUENCE.
RA   Lehmann R.;
RT   "Finding Nemo's genes: A chromosome-scale reference assembly of the genome
RT   of the orange clownfish Amphiprion percula.";
RL   Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSAPEP00000006325.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC   -!- SIMILARITY: Belongs to the protease inhibitor I39 (alpha-2-
CC       macroglobulin) family. {ECO:0000256|ARBA:ARBA00010952}.
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DR   STRING; 161767.ENSAPEP00000006325; -.
DR   Ensembl; ENSAPET00000006494.1; ENSAPEP00000006325.1; ENSAPEG00000004553.1.
DR   GeneTree; ENSGT00940000166660; -.
DR   OMA; PEKGRMD; -.
DR   Proteomes; UP000265080; Chromosome 9.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR   CDD; cd02897; A2M_2; 1.
DR   Gene3D; 1.50.10.20; -; 1.
DR   Gene3D; 2.20.130.20; -; 1.
DR   Gene3D; 2.60.120.1540; -; 1.
DR   Gene3D; 2.60.40.1930; -; 2.
DR   Gene3D; 2.60.40.1940; -; 1.
DR   Gene3D; 2.60.40.690; Alpha-macroglobulin, receptor-binding domain; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR   InterPro; IPR009048; A-macroglobulin_rcpt-bd.
DR   InterPro; IPR036595; A-macroglobulin_rcpt-bd_sf.
DR   InterPro; IPR011625; A2M_N_BRD.
DR   InterPro; IPR041813; A2M_TED.
DR   InterPro; IPR047565; Alpha-macroglob_thiol-ester_cl.
DR   InterPro; IPR011626; Alpha-macroglobulin_TED.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR001599; Macroglobln_a2.
DR   InterPro; IPR019742; MacrogloblnA2_CS.
DR   InterPro; IPR002890; MG2.
DR   InterPro; IPR041555; MG3.
DR   InterPro; IPR040839; MG4.
DR   InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR   PANTHER; PTHR11412:SF160; ALPHA-2-MACROGLOBULIN-LIKE PROTEIN 1; 1.
DR   PANTHER; PTHR11412; MACROGLOBULIN / COMPLEMENT; 1.
DR   Pfam; PF00207; A2M; 1.
DR   Pfam; PF07703; A2M_BRD; 1.
DR   Pfam; PF07677; A2M_recep; 1.
DR   Pfam; PF01835; MG2; 1.
DR   Pfam; PF17791; MG3; 1.
DR   Pfam; PF17789; MG4; 1.
DR   Pfam; PF07678; TED_complement; 1.
DR   SMART; SM01360; A2M; 1.
DR   SMART; SM01359; A2M_N_2; 1.
DR   SMART; SM01361; A2M_recep; 1.
DR   SMART; SM01419; Thiol-ester_cl; 1.
DR   SUPFAM; SSF49410; Alpha-macroglobulin receptor domain; 1.
DR   SUPFAM; SSF81296; E set domains; 1.
DR   SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
DR   PROSITE; PS00477; ALPHA_2_MACROGLOBULIN; 1.
PE   3: Inferred from homology;
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Protease inhibitor {ECO:0000256|ARBA:ARBA00022690};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265080};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525};
KW   Serine protease inhibitor {ECO:0000256|ARBA:ARBA00022900};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           23..1487
FT                   /note="Alpha-2-macroglobulin-like"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5018235546"
FT   DOMAIN          456..606
FT                   /note="Alpha-2-macroglobulin bait region"
FT                   /evidence="ECO:0000259|SMART:SM01359"
FT   DOMAIN          769..858
FT                   /note="Alpha-2-macroglobulin"
FT                   /evidence="ECO:0000259|SMART:SM01360"
FT   DOMAIN          1386..1474
FT                   /note="Alpha-macroglobulin receptor-binding"
FT                   /evidence="ECO:0000259|SMART:SM01361"
SQ   SEQUENCE   1487 AA;  164083 MW;  C7E361A8C3D5488A CRC64;
     MAPVLQMFAV TLAAALLQTA TSAHLNDTIF AVTVSSRVTA GNQETLCALI HGPTEPISLN
     ITLNTEFGNS VILEEDVKED FYRCLSFQVP TVPRRTVASI HVTIQGENAS LGKKTKVLVE
     PPAFIHVVQT DKPIYKPGQT VQFRIVSLDA NFIPVSRVYK EVALQDPNSN RIAQWLDKAI
     VSGILDLSHP MIPEAVQGTY TITALTDKGE QISHSFDIKE YVLPKFEVNV KLPSVITILD
     EEATLRICGK YTYGKPVIGS VKAEFCRRAV RYWYVVRSTD NDICKTYHLT TDKSGCATQT
     VNLTAFALDK TMYTDSFQVS AEMEEYGTGV ILKGNGRTTF NSHIRTASFE DVPAAYKPGI
     PFEGKIKVVG PDNKPASNEP VYLSAGDLQK LVLTTDRKGV ALFSLDTSLW KDSVYLVASS
     KNTTDHHPYV HNLRRAEYRS AHHHVTPFYS KSSSFLKVMQ VNGKLSCDKD TAVRAQYIIQ
     GDELKKGQEV LDFFYLVLSR GAIVLHGHVP VTVKAGTVNK GQLSVPLSQM TNLAPFAQVV
     VYTVMPSGEA VADSLDFPIQ LCLNNKVSLK FSSLQELPAE KTTLSLQAHP GSMCSVRAID
     QSVLLLQAEQ ELNVGYMYSQ LPVQKLSGYS YEVDDFEPYP CFPMPVPEPE IEIAPESTAA
     PTAVPAPDTV PDAQAIRRAT RSLFFGNSDQ KNDVYSIFKE IGIKIMTNSD VKKPYDCRER
     AYEYFLYDAD VVDSPVPMAF NMMPQNSGFV LKEKEEEKKK TVRTFFPETW IWDLVPVGDS
     GAVDVEKTVP DTITKWAAGA FCVSSVGFGV SPNTGLTVFQ PFFVSLTLPY SVIRGEVFTL
     KATVFNYLSK CIMVKVTLDD SDQYTFRNCD GCHYTICLCA EESRTFSWIV TPTALGKLNL
     KVSAEALKTD TLCGNEVATV PDVGRVDTVI RTLLVEAEGT PQMISHNALL CPTDGPVEKK
     ISLLMPEMFV AGSARASVSV LGDLMGRAMK NLDKLLEMPY GCGEQNMLLF APNIFILNYL
     KSTGQLTQKI LDKATHFLES GYQRELTYKH DDGSYSAFGK SDASGNTWLT SFVMKSFGGA
     RPYIYVQPQH IKDARRWLSK HQRPDGCIRS VGKLFHNGMK GGVSDDVSLT AYITAALLEL
     DADATDPVVQ NCLSCLKAAV AGQLDNLYTT ALLSYTFTLA GDQDMRSKLI TTLHQKSNTQ
     GGTRHWERVG ASKKVLDSLE VEITSYVLLA LLSGPAMPDF GLDYSSGIVR WLTQQQNPYG
     GFASTQDTVV ALQALAKYGA ATYSPEGSTT VTVTSLGGLN KGFTVDQSNR LLYQEEKLSE
     VPGEYTIKAQ GQSCVLAQIS MHYNIPPPAD FSAFNISTNT MAKCNISRPQ LILFVHVRYQ
     GRREETNMVI ISIKLLSGYI LDKSSLSLLQ RDRSVKRVDL DEGFINIYLD GLKKAETQIY
     SVTLEEDQPV RNLKPAVVKV YDYYQTSDEA VTDYTSACAE SDTINEL
//
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