ID   A0A3P8S2R7_AMPPE        Unreviewed;       365 AA.
AC   A0A3P8S2R7;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   RecName: Full=Farnesyl pyrophosphate synthase {ECO:0000256|ARBA:ARBA00034546};
DE   AltName: Full=(2E,6E)-farnesyl diphosphate synthase {ECO:0000256|ARBA:ARBA00032873};
DE   AltName: Full=Dimethylallyltranstransferase {ECO:0000256|ARBA:ARBA00032448};
DE   AltName: Full=Farnesyl diphosphate synthase {ECO:0000256|ARBA:ARBA00032424};
DE   AltName: Full=Geranyltranstransferase {ECO:0000256|ARBA:ARBA00032380};
OS   Amphiprion percula (Orange clownfish) (Lutjanus percula).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Pomacentridae; Amphiprion.
OX   NCBI_TaxID=161767 {ECO:0000313|Ensembl:ENSAPEP00000005889.1, ECO:0000313|Proteomes:UP000265080};
RN   [1] {ECO:0000313|Ensembl:ENSAPEP00000005889.1, ECO:0000313|Proteomes:UP000265080}
RP   NUCLEOTIDE SEQUENCE.
RA   Lehmann R.;
RT   "Finding Nemo's genes: A chromosome-scale reference assembly of the genome
RT   of the orange clownfish Amphiprion percula.";
RL   Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSAPEP00000005889.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(2E)-geranyl diphosphate + isopentenyl diphosphate = (2E,6E)-
CC         farnesyl diphosphate + diphosphate; Xref=Rhea:RHEA:19361,
CC         ChEBI:CHEBI:33019, ChEBI:CHEBI:58057, ChEBI:CHEBI:128769,
CC         ChEBI:CHEBI:175763; EC=2.5.1.10;
CC         Evidence={ECO:0000256|ARBA:ARBA00001744};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=dimethylallyl diphosphate + isopentenyl diphosphate = (2E)-
CC         geranyl diphosphate + diphosphate; Xref=Rhea:RHEA:22408,
CC         ChEBI:CHEBI:33019, ChEBI:CHEBI:57623, ChEBI:CHEBI:58057,
CC         ChEBI:CHEBI:128769; EC=2.5.1.1;
CC         Evidence={ECO:0000256|ARBA:ARBA00000969};
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|ARBA:ARBA00001946};
CC   -!- PATHWAY: Isoprenoid biosynthesis; farnesyl diphosphate biosynthesis;
CC       farnesyl diphosphate from geranyl diphosphate and isopentenyl
CC       diphosphate: step 1/1. {ECO:0000256|ARBA:ARBA00005035}.
CC   -!- PATHWAY: Isoprenoid biosynthesis; geranyl diphosphate biosynthesis;
CC       geranyl diphosphate from dimethylallyl diphosphate and isopentenyl
CC       diphosphate: step 1/1. {ECO:0000256|ARBA:ARBA00004932}.
CC   -!- SIMILARITY: Belongs to the FPP/GGPP synthase family.
CC       {ECO:0000256|RuleBase:RU004466}.
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DR   AlphaFoldDB; A0A3P8S2R7; -.
DR   Ensembl; ENSAPET00000006043.1; ENSAPEP00000005889.1; ENSAPEG00000004219.1.
DR   GeneTree; ENSGT00900000141074; -.
DR   OMA; LEMGNFF; -.
DR   Proteomes; UP000265080; Chromosome 7.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0016765; F:transferase activity, transferring alkyl or aryl (other than methyl) groups; IEA:InterPro.
DR   GO; GO:0008299; P:isoprenoid biosynthetic process; IEA:UniProtKB-KW.
DR   CDD; cd00685; Trans_IPPS_HT; 1.
DR   Gene3D; 1.10.600.10; Farnesyl Diphosphate Synthase; 1.
DR   InterPro; IPR039702; FPS1-like.
DR   InterPro; IPR008949; Isoprenoid_synthase_dom_sf.
DR   InterPro; IPR000092; Polyprenyl_synt.
DR   InterPro; IPR033749; Polyprenyl_synt_CS.
DR   PANTHER; PTHR11525:SF0; FARNESYL PYROPHOSPHATE SYNTHASE; 1.
DR   PANTHER; PTHR11525; FARNESYL-PYROPHOSPHATE SYNTHETASE; 1.
DR   Pfam; PF00348; polyprenyl_synt; 1.
DR   SFLD; SFLDS00005; Isoprenoid_Synthase_Type_I; 1.
DR   SFLD; SFLDG01017; Polyprenyl_Transferase_Like; 1.
DR   SUPFAM; SSF48576; Terpenoid synthases; 1.
DR   PROSITE; PS00723; POLYPRENYL_SYNTHASE_1; 1.
DR   PROSITE; PS00444; POLYPRENYL_SYNTHASE_2; 1.
PE   3: Inferred from homology;
KW   Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265080};
KW   Transferase {ECO:0000256|RuleBase:RU004466}.
SQ   SEQUENCE   365 AA;  41997 MW;  54C2DD712532A3AD CRC64;
     MKKDSVIMVD QVCNRTLSKK PLLSDPQLFE AQFEELLTEL TERDLTDPVL ADALSRLRKV
     LVYNAPGGKR NRGLSVIGSL RELLPPAELT QDIVQRALVI GWCTELIQAF FLVADDIMDA
     SLTRRGQPCW YKMDGIGLDA INDAFLLEST IYRLLRRHCR DQPYYVHLLE LFNETAYQTE
     LGQALDLITA PPGRIDLNRF TMERYKAIVK YKTAFYSFYL PVAAAMFMAG ISSEEEHSNA
     KHILLEMGEF FQIQDDYLDC YGDPAVTGKI GTDIQDNKCS WLVVTALEVM SPEQRAELEV
     SYGRKDEASV RKVKALYDSL QMPRRYHDYE EESYQRLQKL IGRHAQNLPH SIFLNFAKKI
     YKRNK
//