ID A0A3P8S2Z8_AMPPE Unreviewed; 1409 AA.
AC A0A3P8S2Z8;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Adhesion G protein-coupled receptor F5-like {ECO:0008006|Google:ProtNLM};
OS Amphiprion percula (Orange clownfish) (Lutjanus percula).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Amphiprion.
OX NCBI_TaxID=161767 {ECO:0000313|Ensembl:ENSAPEP00000006596.1, ECO:0000313|Proteomes:UP000265080};
RN [1] {ECO:0000313|Ensembl:ENSAPEP00000006596.1, ECO:0000313|Proteomes:UP000265080}
RP NUCLEOTIDE SEQUENCE.
RA Lehmann R.;
RT "Finding Nemo's genes: A chromosome-scale reference assembly of the genome
RT of the orange clownfish Amphiprion percula.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPEP00000006596.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family.
CC Adhesion G-protein coupled receptor (ADGR) subfamily.
CC {ECO:0000256|ARBA:ARBA00007343}.
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DR Ensembl; ENSAPET00000006735.1; ENSAPEP00000006565.1; ENSAPEG00000004683.1.
DR Ensembl; ENSAPET00000006766.1; ENSAPEP00000006596.1; ENSAPEG00000004683.1.
DR GeneTree; ENSGT00940000154603; -.
DR OMA; PDGQYCQ; -.
DR Proteomes; UP000265080; Chromosome 11.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IEA:UniProt.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR CDD; cd15932; 7tmB2_GPR116-like_Adhesion_VI; 1.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR008078; GPCR_2_Ig-hepta-like_rcpt.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR000082; SEA_dom.
DR InterPro; IPR036364; SEA_dom_sf.
DR PANTHER; PTHR45813:SF4; ADHESION G PROTEIN-COUPLED RECEPTOR F5; 1.
DR PANTHER; PTHR45813; EF-HAND DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF01825; GPS; 1.
DR Pfam; PF01390; SEA; 1.
DR PRINTS; PR00249; GPCRSECRETIN.
DR PRINTS; PR01695; IGHEPTARCPTR.
DR SMART; SM00303; GPS; 1.
DR SMART; SM00409; IG; 2.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF82671; SEA domain; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS50024; SEA; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000265080};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..1409
FT /note="Adhesion G protein-coupled receptor F5-like"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5040591950"
FT TRANSMEM 1075..1093
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1114..1135
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1155..1180
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1192..1219
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1239..1263
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1284..1303
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1315..1337
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 455..562
FT /note="SEA"
FT /evidence="ECO:0000259|PROSITE:PS50024"
FT DOMAIN 562..650
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1072..1338
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 394..455
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1389..1409
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 395..420
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 421..435
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 436..455
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1409 AA; 153872 MW; A88923CC6F5770BB CRC64;
MEISKNVLVI FALAVTLILE TRTFDEYSRI DLPENHDEHF LPHTRQRREA LSDQRNYTVD
IIVNVSDAEE YQKILFALNA TSFPIHLSNN TEIIETSVTT VCFSTGSGFK CNCAKQFAWS
YNNCVTYGAC DSISSGICKC INAIPPDGQS CRPISELLAQ VEYEVEVELN VTDIETLNHL
RSLLINGSYF LALSPIVNIT HINITTVCSM SNDGFQCRCE DQYRWSCDQC LKYGSCDNIT
DDTCGCINAF FPDGLYCQSV YQHNFTACPL TTTLPPTTPP VVNECLITVE LNTTDIIVVE
TLRTILSNIS YSIIISDQIQ VSDINFTTAC YPNGSTYQCR CEEPYSWPCH LCSTSGKCND
VFENTCGCIN TIPPGGVYCQ LLTEICPSPP LPTATLGPIQ STTTTSSTTP TRIPTTSVPT
AAPTSPTPLP TTTTNPATSP TPVTTTTIAT PATTPPTVIN VTMSVRLDLE FTEDLTDKST
PAYKELESGI NSVLQEQYNS ISGVRRAFVT GFRPGSVITD FVVQAIEVNA REIAEANNNL
PSAMESLIAP VLGSVVAQYT SPTSLRIPGP IYTGQTVMLT CGPPDIDVGT ISGSVWKFEG
LAISSDRIIA TTAGSQSTLM VNNIIPADAG LYECTMEGTD LRFVQTGKVT EIIEAPIVRL
QSKVSVKCEE GDVPLQCCVQ SPYTVRWFDG INNLASSPTE EAECIQHNYQ IENCNSSQTR
EEIFTCRVNE LEGYDQTTTL TVFIESVECN NTQYGTGREG DTASARCDAG QEGEKIARCQ
NRQWRLVQDT CILVQIRLLL IGSQDLALET VPEFVGNLSA AVRTEAAVIP SSPATISAIV
DILNNVANLT TVVNENVMED LLETVDVIIG DDSRESWLFL NSNQTNNASS GLLGSLETLS
NGLNGTFIIE TQRIQLNRTM FTDSFNAMLN SSVAINIPNT NFSNVFITTI ILSTFNNVMP
VRNSSFDVSL LNATTNETVP DNAINAAVLL VKITESISNV TLSYNKLNES LSLNPQCVFW
NFTFFDGLGA WDDEGCTFVS DINNTVTCSC NHLTSFSILM ATDIPPSIRS DLEKITYAGV
GISLASLVIC LIIEGYVWKE ITRNSTAFMR HVSIINTALS LLIANICFMI GASIAKNPLE
DDEDDYTVPV GPCSTATFFM HFFYLALFFW MLVSGLLLFY RTVMVFSHMS KSTMLAIGLI
LGYGCPLIIA VITVAVTAPG NGYIRKNNAC WLNWFETKAL LAMVIPALTI VFINILIVIV
VLFKMLRRGM GDTAQTDGKH TMVVIIRCVA ILTPLFGLTW SLGVGTMISP TNAGIHIAFA
FFNSLQGFFI LVFGTLMDSK IRAILSKSMP RPASGSNQTR STSGGISSFS GMNLINRLRG
RKNVYRVSNA TNSSNNNSSA SETFINVHE
//