ID A0A3P8S394_AMPPE Unreviewed; 685 AA.
AC A0A3P8S394;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Receptor (TNFRSF)-interacting serine-threonine kinase 1, like {ECO:0000313|Ensembl:ENSAPEP00000006542.1};
OS Amphiprion percula (Orange clownfish) (Lutjanus percula).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Amphiprion.
OX NCBI_TaxID=161767 {ECO:0000313|Ensembl:ENSAPEP00000006542.1, ECO:0000313|Proteomes:UP000265080};
RN [1] {ECO:0000313|Ensembl:ENSAPEP00000006542.1, ECO:0000313|Proteomes:UP000265080}
RP NUCLEOTIDE SEQUENCE.
RA Lehmann R.;
RT "Finding Nemo's genes: A chromosome-scale reference assembly of the genome
RT of the orange clownfish Amphiprion percula.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPEP00000006542.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3P8S394; -.
DR STRING; 161767.ENSAPEP00000006542; -.
DR Ensembl; ENSAPET00000006712.1; ENSAPEP00000006542.1; ENSAPEG00000004703.1.
DR GeneTree; ENSGT00940000159347; -.
DR OMA; DIIEHCP; -.
DR Proteomes; UP000265080; Chromosome 10.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0070887; P:cellular response to chemical stimulus; IEA:UniProt.
DR GO; GO:0008152; P:metabolic process; IEA:UniProt.
DR GO; GO:0043123; P:positive regulation of canonical NF-kappaB signal transduction; IEA:UniProt.
DR GO; GO:0031349; P:positive regulation of defense response; IEA:UniProt.
DR GO; GO:0032103; P:positive regulation of response to external stimulus; IEA:UniProt.
DR GO; GO:0010033; P:response to organic substance; IEA:UniProt.
DR GO; GO:0006950; P:response to stress; IEA:UniProt.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR025735; RHIM_dom.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR23257:SF983; RECEPTOR INTERACTING SERINE_THREONINE KINASE 1; 1.
DR PANTHER; PTHR23257; SERINE-THREONINE PROTEIN KINASE; 1.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR Pfam; PF12721; RHIM; 1.
DR SMART; SM00005; DEATH; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50017; DEATH_DOMAIN; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 4: Predicted;
KW Isopeptide bond {ECO:0000256|ARBA:ARBA00022499};
KW Reference proteome {ECO:0000313|Proteomes:UP000265080};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT DOMAIN 16..289
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 591..677
FT /note="Death"
FT /evidence="ECO:0000259|PROSITE:PS50017"
FT REGION 327..351
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 427..455
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 491..527
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 327..348
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 434..455
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 491..510
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 685 AA; 77405 MW; 1C2A41F93DB7853C CRC64;
MATAPQSSLH MRSTDLIKKE PLDYGGFGEV YLCYHVTLGQ VVMKTMYTGP LRNEENKRSL
LEEGNIMASL NHERVVKLLG VIMEDRDYSL VMELIPRGNL LVMLQTVDVP VSIKGRIILE
ILEGMVYLTE KRVLHKDIKP ENILVDKDFH IKIADLGLAT FQTWSKLTKE ESRRKSGKVR
SAGMRGAGTL SYMAPEHLES IHTPSTEKSD VYSFAIVVWV ILTREEPYAN ARSEDQISQC
VRKGDRPAED LIPEDTPTEI IELMKRCWDH NPEQRPTFEE AYNCFHPFYM ETLEQHVEGD
LLNLRMDYEG PEELVEKMKS LSMNHEYFSP SEHDSPAPLV SSDRSVSEPV EASIEDLHDI
PYEPSVESIQ TDARANNAPS ALEEKLDREL NYHKHGSYNC ENQPYESNSF NNYSNPFLQN
HMSTSDHAIR QPEQDRSSVQ SWTKGGPVQP TSQEEALHRP TAGLYESMNS STPTPSHLPM
YASTLSLPQL NQQHPHSHYD RQQSWPAYPV SDTSAPDATI GRLLNPSKCA SPQDQGSLYI
HNASGIQIGS HNTMSIRGYD PSLSCSSIST TCPAISPIKE GILKYDDYAV TEQHLDLLRD
NIGAKWKRCA RRLGLSGVEI ETIEFDYFRD GLPEMVHQML ERWKMKEGSI GCTIGKLCRA
LEGNIKVDII QKILDICSSS SLQMS
//
