ID A0A3P8S4D6_AMPPE Unreviewed; 843 AA.
AC A0A3P8S4D6;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=G-protein coupled receptors family 3 profile domain-containing protein {ECO:0000259|PROSITE:PS50259};
OS Amphiprion percula (Orange clownfish) (Lutjanus percula).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Amphiprion.
OX NCBI_TaxID=161767 {ECO:0000313|Ensembl:ENSAPEP00000006952.1, ECO:0000313|Proteomes:UP000265080};
RN [1] {ECO:0000313|Ensembl:ENSAPEP00000006952.1, ECO:0000313|Proteomes:UP000265080}
RP NUCLEOTIDE SEQUENCE.
RA Lehmann R.;
RT "Finding Nemo's genes: A chromosome-scale reference assembly of the genome
RT of the orange clownfish Amphiprion percula.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPEP00000006952.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR AlphaFoldDB; A0A3P8S4D6; -.
DR Ensembl; ENSAPET00000007136.1; ENSAPEP00000006952.1; ENSAPEG00000004774.1.
DR GeneTree; ENSGT00940000162782; -.
DR OMA; IRQFWEH; -.
DR Proteomes; UP000265080; Chromosome 9.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR CDD; cd15283; 7tmC_V2R_pheromone; 1.
DR CDD; cd06364; PBP1_CaSR; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 2.10.50.30; GPCR, family 3, nine cysteines domain; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR011500; GPCR_3_9-Cys_dom.
DR InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR000068; GPCR_3_Ca_sens_rcpt-rel.
DR InterPro; IPR017979; GPCR_3_CS.
DR InterPro; IPR004073; GPCR_3_vmron_rcpt_2.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR24061:SF418; C-FAMILY ODORANT RECEPTOR OLFCQ19-RELATED; 1.
DR PANTHER; PTHR24061; CALCIUM-SENSING RECEPTOR-RELATED; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF07562; NCD3G; 1.
DR PRINTS; PR00248; GPCRMGR.
DR PRINTS; PR01535; VOMERONASL2R.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS00980; G_PROTEIN_RECEP_F3_2; 1.
DR PROSITE; PS00981; G_PROTEIN_RECEP_F3_3; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000265080};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 573..597
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 612..632
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 644..668
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 689..709
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 729..757
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 769..789
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 801..824
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 574..839
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
SQ SEQUENCE 843 AA; 93335 MW; D8D2E678873B6ADD CRC64;
MASHGLQEQF YLNGIHKPGD VMLGGLFEVH YTSIFPELTF TSEPSKLSWF RHAMTMAFAI
DEINRNSNLL PNVTLGYSLY DNCATLVIGF SAALSLVSGR EEQFLLLENC SGTSPVLGIV
GDSFSTFSIA TSDVIGLFNL PIVSYFATCS CLSDGHRFPS FFRTIPSDAF QVHAMIQILK
HFGWTWAGLL ISDDDYGHHA AQSFQTELVQ SGGGCLAYTE ILPWGENTAE LWRIVQMMKK
STARVVIVFA HQITMIQLME EVVRQNVTGL QWMASEAWTT AAVLQTPHLM PYLGGTLGIA
IRRGEIPGLR DFLLRTHPDL YDNNNHGNSM VRMFWEHTFQ CRFPPPPAGW VESGGAICTG
EEVLESVETE FLDVSNLRAE YNVYKAVYAL AYALDDMLQC TPGRGPFSGN SCTTLQTMEP
WQFLHYLEKV NFTTSFGDQV SFDEKGDALP IYDVMNWLWI PDGRTKVQNV GVVKKTTLTG
EELTLDEDKI FWNFDSKQPP RSVCSDSCPP GTRMARKNGQ PVCCFDCVLC SEGKFSNKPD
SVECTSCPED FASSPQRDHC VPKKIEFLSY HEPLGICLTS TSLLGTFICA VVLGIFIHHR
STPVVRANNS ELSFLILMSL KLCFLCSLLF IGRPRLWTCQ LRHAAFGISF VLCVSCILVK
TMVVLAVFKA SKPGGGASLK WFGAVQQRGT VLLLTCIQAA ICVVWIVSAS PLPHKNTQYH
SDKIVYECVV GSTVGFAVLL GYIGLLAILS FLLAFLARNL PDNFNEAKLI TFSMLIFCAV
WVAFVPAYVN SPGKYADAVE VFAILASSFG LLVALFGPKC YIILLRPERN TKKAIMGRAT
SKS
//
