ID A0A3P8S4L7_AMPPE Unreviewed; 242 AA.
AC A0A3P8S4L7;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE RecName: Full=Metalloproteinase inhibitor 4 {ECO:0000256|ARBA:ARBA00013515};
DE AltName: Full=Tissue inhibitor of metalloproteinases 4 {ECO:0000256|ARBA:ARBA00030105};
GN Name=TIMP4 {ECO:0000313|Ensembl:ENSAPEP00000007047.1};
OS Amphiprion percula (Orange clownfish) (Lutjanus percula).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Amphiprion.
OX NCBI_TaxID=161767 {ECO:0000313|Ensembl:ENSAPEP00000007047.1, ECO:0000313|Proteomes:UP000265080};
RN [1] {ECO:0000313|Ensembl:ENSAPEP00000007047.1, ECO:0000313|Proteomes:UP000265080}
RP NUCLEOTIDE SEQUENCE.
RA Lehmann R.;
RT "Finding Nemo's genes: A chromosome-scale reference assembly of the genome
RT of the orange clownfish Amphiprion percula.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPEP00000007047.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the protease inhibitor I35 (TIMP) family.
CC {ECO:0000256|ARBA:ARBA00011027}.
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DR AlphaFoldDB; A0A3P8S4L7; -.
DR STRING; 161767.ENSAPEP00000007047; -.
DR Ensembl; ENSAPET00000007232.1; ENSAPEP00000007047.1; ENSAPEG00000005027.1.
DR GeneTree; ENSGT00940000159798; -.
DR Proteomes; UP000265080; Chromosome 6.
DR GO; GO:0008191; F:metalloendopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR CDD; cd03585; NTR_TIMP; 1.
DR Gene3D; 2.40.50.120; -; 1.
DR Gene3D; 3.90.370.10; Tissue inhibitor of metalloproteinase-1. Chain B, domain 1; 1.
DR InterPro; IPR001134; Netrin_domain.
DR InterPro; IPR001820; TIMP.
DR InterPro; IPR008993; TIMP-like_OB-fold.
DR InterPro; IPR027465; TIMP_C.
DR PANTHER; PTHR11844; METALLOPROTEASE INHIBITOR; 1.
DR PANTHER; PTHR11844:SF26; METALLOPROTEINASE INHIBITOR 4; 1.
DR Pfam; PF00965; TIMP; 1.
DR SMART; SM00206; NTR; 1.
DR SUPFAM; SSF50242; TIMP-like; 1.
DR PROSITE; PS50189; NTR; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW ECO:0000256|PIRSR:PIRSR601820-3};
KW Metalloenzyme inhibitor {ECO:0000256|ARBA:ARBA00023215};
KW Metalloprotease inhibitor {ECO:0000256|ARBA:ARBA00022608};
KW Protease inhibitor {ECO:0000256|ARBA:ARBA00022690};
KW Reference proteome {ECO:0000313|Proteomes:UP000265080}.
FT DOMAIN 35..174
FT /note="NTR"
FT /evidence="ECO:0000259|PROSITE:PS50189"
FT DISULFID 176..223
FT /evidence="ECO:0000256|PIRSR:PIRSR601820-3"
FT DISULFID 181..186
FT /evidence="ECO:0000256|PIRSR:PIRSR601820-3"
FT DISULFID 194..215
FT /evidence="ECO:0000256|PIRSR:PIRSR601820-3"
SQ SEQUENCE 242 AA; 27798 MW; 43B46C23AABA903A CRC64;
MQFKNEVYQS YSEETSRTVF LDIFYKVPRP ALLLQAMLRT LIKLQRSTQV HICLFVCPPF
YPLALIRAKI SGEKIVSPSN SSSPYMKMIQ YEIKMIKMFK GFDKAKDIQY VYTPVFSSLC
GVKLDSNNKA GYLLSGSMWS DGRISIGQCD LVESWDNLSL SQKKNLNYRY QMGCECRINT
CYTVPCASTG DNECLWTDWL LDNSLNGEQA RQYACIRRSD TTCSWYRGGP PPEKDFLDMT
DP
//