ID A0A3P8S5Z8_AMPPE Unreviewed; 880 AA.
AC A0A3P8S5Z8;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=PNPLA domain-containing protein {ECO:0000259|PROSITE:PS51635};
OS Amphiprion percula (Orange clownfish) (Lutjanus percula).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Amphiprion.
OX NCBI_TaxID=161767 {ECO:0000313|Ensembl:ENSAPEP00000007532.1, ECO:0000313|Proteomes:UP000265080};
RN [1] {ECO:0000313|Ensembl:ENSAPEP00000007532.1, ECO:0000313|Proteomes:UP000265080}
RP NUCLEOTIDE SEQUENCE.
RA Lehmann R.;
RT "Finding Nemo's genes: A chromosome-scale reference assembly of the genome
RT of the orange clownfish Amphiprion percula.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPEP00000007532.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3P8S5Z8; -.
DR STRING; 161767.ENSAPEP00000007532; -.
DR Ensembl; ENSAPET00000007749.1; ENSAPEP00000007532.1; ENSAPEG00000005407.1.
DR GeneTree; ENSGT00940000154738; -.
DR Proteomes; UP000265080; Chromosome 4.
DR GO; GO:0004620; F:phospholipase activity; IEA:InterPro.
DR GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-UniRule.
DR CDD; cd07211; Pat_PNPLA8; 1.
DR Gene3D; 3.40.1090.10; Cytosolic phospholipase A2 catalytic domain; 1.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR045217; PNPLA8-like.
DR InterPro; IPR002641; PNPLA_dom.
DR PANTHER; PTHR24185; CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA; 1.
DR PANTHER; PTHR24185:SF1; CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA; 1.
DR Pfam; PF01734; Patatin; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR PROSITE; PS51635; PNPLA; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Reference proteome {ECO:0000313|Proteomes:UP000265080}.
FT DOMAIN 505..737
FT /note="PNPLA"
FT /evidence="ECO:0000259|PROSITE:PS51635"
FT REGION 149..215
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 240..259
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 290..338
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 385..416
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 149..212
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 880 AA; 97541 MW; 3716876284C2F215 CRC64;
MNNRLAPHTL GKMSRSFHMW QIHARKSAAS LPLCGTSHCR IHAQQPACYK AGYCSWKHIH
HLRLRGRKGW ISKASQVRQR LGLHTSTLYL NTSTSKWSAG LSQHMSRVRS TLDTVSKAVS
GTHTDLLAKI ARLKPNALKA GKNAEASIES TANAEENAVT PIPAATSAST TTKPVVNSSS
ASPSLSNSAP TLDASATTST HPHSSTQAAV PATIPTVREV KEKRLRRVVP AVKATCARKK
EELPPSLKET ESKTTTSKQN TALFHPSTLS VSLDETYTYL AHHINSYFGS TTKTQDKTGS
SVEKSSISSQ DQQTSDLIAV SDKTESPTPV TPPSSRRGLG QYLSYSAPTV QAFVGNYIAT
LVPKFRTADP KNATVEEKKP EDVSIKQVEA TISKEQKAAE EKAKKLLLQR EKIIARVSVD
NRTRALVQAL HRASDVRVYI NRVEDLSYHL LEFPETCGVA VKEKVIPCLL RLEQANDPGL
RAAVREALAL VGYHKPVKGR GIRILSIDGG GLRGLLALQT LHKLEALTGK PIYKLFDYIC
GVSTGAILGF MLGVFQVPLK ECDDLYRKLG SDVFKQNVIV GTVKMGWSHA FYDSEAWEKI
LKEKMGSHLL VETSRNPECP KVAAVSTIVN RGTSLKAYVF RNYNLLPGLR SHYLGGCQHQ
LWQAIRATSA APGYFQEFTL GNDLHQVCYR LVYFKRRVKN SRFLCVQVRS CLIDFSNFPH
FFADGGLLIN NPTALAVHEC KCLWPDTPLE CVVSLGTGRF EAPGKNSKTY TSLKTKLTNV
ISSATDTEEV HAMLDAFLPL DTYFRFNPHM SEDISLDENR QEKLNLLQAE GVRYLERNEE
KLNKVARILT REKSSVQRMS DWARLRADMY NSLSFNSSRF
//
