ID   A0A3P8S742_AMPPE        Unreviewed;       645 AA.
AC   A0A3P8S742;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   24-JAN-2024, entry version 21.
DE   RecName: Full=procollagen-proline 3-dioxygenase {ECO:0000256|ARBA:ARBA00012262};
DE            EC=1.14.11.7 {ECO:0000256|ARBA:ARBA00012262};
GN   Name=P3H2 {ECO:0000313|Ensembl:ENSAPEP00000008603.1};
OS   Amphiprion percula (Orange clownfish) (Lutjanus percula).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Pomacentridae; Amphiprion.
OX   NCBI_TaxID=161767 {ECO:0000313|Ensembl:ENSAPEP00000008603.1, ECO:0000313|Proteomes:UP000265080};
RN   [1] {ECO:0000313|Ensembl:ENSAPEP00000008603.1, ECO:0000313|Proteomes:UP000265080}
RP   NUCLEOTIDE SEQUENCE.
RA   Lehmann R.;
RT   "Finding Nemo's genes: A chromosome-scale reference assembly of the genome
RT   of the orange clownfish Amphiprion percula.";
RL   Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSAPEP00000008603.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=Fe cation; Xref=ChEBI:CHEBI:24875;
CC         Evidence={ECO:0000256|ARBA:ARBA00001962};
CC   -!- COFACTOR:
CC       Name=L-ascorbate; Xref=ChEBI:CHEBI:38290;
CC         Evidence={ECO:0000256|ARBA:ARBA00001961};
CC   -!- SIMILARITY: Belongs to the leprecan family.
CC       {ECO:0000256|ARBA:ARBA00006487}.
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DR   AlphaFoldDB; A0A3P8S742; -.
DR   Ensembl; ENSAPET00000008847.1; ENSAPEP00000008603.1; ENSAPEG00000006169.1.
DR   GeneTree; ENSGT00940000159593; -.
DR   Proteomes; UP000265080; Chromosome 2.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-KW.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0031418; F:L-ascorbic acid binding; IEA:InterPro.
DR   GO; GO:0019797; F:procollagen-proline 3-dioxygenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0032963; P:collagen metabolic process; IEA:InterPro.
DR   Gene3D; 2.60.120.620; q2cbj1_9rhob like domain; 1.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR   InterPro; IPR005123; Oxoglu/Fe-dep_dioxygenase.
DR   InterPro; IPR039575; P3H.
DR   InterPro; IPR006620; Pro_4_hyd_alph.
DR   InterPro; IPR044862; Pro_4_hyd_alph_FE2OG_OXY.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR14049; LEPRECAN 1; 1.
DR   PANTHER; PTHR14049:SF1; PROLYL 3-HYDROXYLASE 2; 1.
DR   Pfam; PF13640; 2OG-FeII_Oxy_3; 1.
DR   SMART; SM00702; P4Hc; 1.
DR   PROSITE; PS51471; FE2OG_OXY; 1.
PE   3: Inferred from homology;
KW   Dioxygenase {ECO:0000256|ARBA:ARBA00022964};
KW   Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Iron {ECO:0000256|ARBA:ARBA00023004};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265080};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           25..645
FT                   /note="procollagen-proline 3-dioxygenase"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5017943932"
FT   DOMAIN          494..608
FT                   /note="Fe2OG dioxygenase"
FT                   /evidence="ECO:0000259|PROSITE:PS51471"
SQ   SEQUENCE   645 AA;  73582 MW;  BC452C12E1C45F52 CRC64;
     MDGNSPPAAV WCVVLLCAAL SSSAAFLEPY DLLYDTAVRA FYSSDYGGVV RSMEAALSSH
     REVRRTKVRC RLRCQDQHPF EETFSDLRFF DAVLRRAACM DKCIEEKLGA QSVHKVSEDV
     VQDFNRRIPY NYLQLAYQKL NQPDKAAAAA HTYFQANPEH VEMGQDLEQY KDLQGVQEDH
     FVDREARPHQ RSFTAAVRLY DKGDYEAALG LFEEALVEYY KADVDCRALC QGPQRFEGHD
     HLRYRYSLHE LVSDHFTQVL HCEHECVRDL ATRPGRLSPM ENYLPLHYDY LQFAYFKGTC
     ALQCALTYLL FHDGEEFMTD NVDYFREVLG HDGKPREVRI SNQELHKSDI FKSLFPASFS
     IFSVNALSKY SKYPGICAGG PLLYDNVQLV QNSVALNGTQ RVLLDHVISE DECADLRYLA
     HAVTMAGDGY RGRMSPHTPN EKFEGATVLK TLQYGFEGRV PMRNARLFYD TSERARRIIE
     SYFMLNSTLH FSYTHLVCRT AITGQQDHRN DLSHPIHADN CLLDPDANEC WKEPPAYTYR
     DYSALLYLNG DFEGGEFIFT EMDAKTVTAS VKPRCGRMVG FSSGGENPHG VKAVTRGQRC
     AVALWFTLDP LFRELERLQA DEVIQALDTQ SVWGQGLNIN PKDEL
//