ID A0A3P8S8G6_AMPPE Unreviewed; 736 AA.
AC A0A3P8S8G6;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Forkhead box O6 a {ECO:0000313|Ensembl:ENSAPEP00000009053.1};
OS Amphiprion percula (Orange clownfish) (Lutjanus percula).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Amphiprion.
OX NCBI_TaxID=161767 {ECO:0000313|Ensembl:ENSAPEP00000009053.1, ECO:0000313|Proteomes:UP000265080};
RN [1] {ECO:0000313|Ensembl:ENSAPEP00000009053.1, ECO:0000313|Proteomes:UP000265080}
RP NUCLEOTIDE SEQUENCE.
RA Lehmann R.;
RT "Finding Nemo's genes: A chromosome-scale reference assembly of the genome
RT of the orange clownfish Amphiprion percula.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPEP00000009053.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00089}.
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DR AlphaFoldDB; A0A3P8S8G6; -.
DR STRING; 161767.ENSAPEP00000009053; -.
DR Ensembl; ENSAPET00000009303.1; ENSAPEP00000009053.1; ENSAPEG00000006518.1.
DR GeneTree; ENSGT00940000165224; -.
DR OMA; QTPVYHY; -.
DR Proteomes; UP000265080; Chromosome 7.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR CDD; cd20063; FH_FOXO6; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR047410; FH_FOXO6.
DR InterPro; IPR001766; Fork_head_dom.
DR InterPro; IPR032067; FOXO-TAD.
DR InterPro; IPR032068; FOXO_KIX-bd.
DR InterPro; IPR030456; TF_fork_head_CS_2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR45767; FORKHEAD BOX PROTEIN O; 1.
DR PANTHER; PTHR45767:SF5; FORKHEAD BOX PROTEIN O6; 1.
DR Pfam; PF00250; Forkhead; 1.
DR Pfam; PF16676; FOXO-TAD; 1.
DR Pfam; PF16675; FOXO_KIX_bdg; 1.
DR PRINTS; PR00053; FORKHEAD.
DR SMART; SM00339; FH; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS00658; FORK_HEAD_2; 1.
DR PROSITE; PS50039; FORK_HEAD_3; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00089}; Nucleus {ECO:0000256|PROSITE-ProRule:PRU00089};
KW Reference proteome {ECO:0000313|Proteomes:UP000265080}.
FT DOMAIN 113..207
FT /note="Fork-head"
FT /evidence="ECO:0000259|PROSITE:PS50039"
FT DNA_BIND 113..207
FT /note="Fork-head"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00089"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 218..270
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 295..337
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 362..381
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 468..559
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..19
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 311..327
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 468..482
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 500..514
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 515..548
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 736 AA; 79096 MW; C0ECDABC09FDA4DE CRC64;
MLMMEDDELD THQVDSDFEP QSRPRSCTWP LPCPQDFPGG HEVSGGLPLA NIKVEPEDVP
ACRAGLVGGT PGELKHPAGA PAPTGATHPC LAGAALDVTG PLRKAKSSRR NAWGNQSYAD
LITRAIESTP EKRLTLSQIY DWMVRYVPYF KDKGDSNSSA GWKNSIRHNL SLHTRFIRVQ
NEGTGKSSWW MLNPDGGKMG KAPRRRAVSM DNSTKYLKSK GRIRGKRVGR PGIGAGSAVV
GLQSSPDHGS PPRKGLPQAG GATGTDGEFD AWTDLHSRAS SSASTLSGRL SPILAEEEPE
EPEEGGLSCS TSPHLYPSPT SARSPSMGAG NHCPPLEQLP QLASLTGAIS LDEQMIEDGY
HHHRPQQQQH QQHPSVGRHK HQTPVYHYSS GVKGQSSYGA GVYGTTGIGM LRHHSPMQTI
QENKPASFSG TMRAYSSTNA LQSLLTGGPA GQQYCSKDMI LGQERESHSM MGQATNGVGS
SHHSHHPGHH NDHSHNGPHS HSSAHSHNRT HSHTSSHNHS NVTNHNHNSP HSLAHNGHSL
NQSHSHTPPR AAALAPRGSS NQLQTYNHKA PYLYSPPSHA HLPASTTLPP NPAGMLGMPQ
DSCHVATAPH PRHNHYPDLQ HLSMTNGSYH HGQGMGNGSS GCNYHGYHQP HPHERLPADL
DIDMFHGSLD CDVESILLHD IMDSGEEMDF NFDCSLAQGV GIGMGMGMGV TMGMGMGMSG
LACPQQAHSN QSWVPG
//
