ID A0A3P8S923_AMPPE Unreviewed; 1717 AA.
AC A0A3P8S923;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE RecName: Full=5'-3' exoribonuclease 1 {ECO:0000256|PIRNR:PIRNR006743};
DE EC=3.1.13.- {ECO:0000256|PIRNR:PIRNR006743};
OS Amphiprion percula (Orange clownfish) (Lutjanus percula).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Amphiprion.
OX NCBI_TaxID=161767 {ECO:0000313|Ensembl:ENSAPEP00000009248.1, ECO:0000313|Proteomes:UP000265080};
RN [1] {ECO:0000313|Ensembl:ENSAPEP00000009248.1, ECO:0000313|Proteomes:UP000265080}
RP NUCLEOTIDE SEQUENCE.
RA Lehmann R.;
RT "Finding Nemo's genes: A chromosome-scale reference assembly of the genome
RT of the orange clownfish Amphiprion percula.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPEP00000009248.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|PIRNR:PIRNR006743}.
CC -!- SIMILARITY: Belongs to the 5'-3' exonuclease family.
CC {ECO:0000256|ARBA:ARBA00038299, ECO:0000256|PIRNR:PIRNR006743}.
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DR STRING; 161767.ENSAPEP00000009248; -.
DR Ensembl; ENSAPET00000009501.1; ENSAPEP00000009248.1; ENSAPEG00000006620.1.
DR GeneTree; ENSGT00670000098080; -.
DR Proteomes; UP000265080; Chromosome 10.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008409; F:5'-3' exonuclease activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000956; P:nuclear-transcribed mRNA catabolic process; IEA:InterPro.
DR CDD; cd18673; PIN_XRN1-2-like; 1.
DR Gene3D; 1.25.40.1050; -; 1.
DR Gene3D; 2.170.260.40; -; 1.
DR Gene3D; 2.30.30.750; -; 1.
DR Gene3D; 3.40.50.12390; -; 1.
DR InterPro; IPR027073; 5_3_exoribonuclease.
DR InterPro; IPR016494; 5_3_exoribonuclease_1.
DR InterPro; IPR041385; SH3_12.
DR InterPro; IPR040992; XRN1_D1.
DR InterPro; IPR047007; XRN1_D1_sf.
DR InterPro; IPR041106; XRN1_D2_D3.
DR InterPro; IPR041412; Xrn1_helical.
DR InterPro; IPR004859; Xrn1_N.
DR InterPro; IPR047008; XRN1_SH3_sf.
DR PANTHER; PTHR12341:SF7; 5'-3' EXORIBONUCLEASE 1; 1.
DR PANTHER; PTHR12341; 5'->3' EXORIBONUCLEASE; 1.
DR Pfam; PF18129; SH3_12; 1.
DR Pfam; PF18332; XRN1_D1; 1.
DR Pfam; PF18334; XRN1_D2_D3; 1.
DR Pfam; PF17846; XRN_M; 1.
DR Pfam; PF03159; XRN_N; 1.
DR PIRSF; PIRSF006743; Exonuclease_Xnr1; 2.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|PIRNR:PIRNR006743};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839, ECO:0000256|PIRNR:PIRNR006743};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PIRNR:PIRNR006743};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722, ECO:0000256|PIRNR:PIRNR006743};
KW Reference proteome {ECO:0000313|Proteomes:UP000265080};
KW RNA-binding {ECO:0000256|PIRNR:PIRNR006743}.
FT DOMAIN 1..227
FT /note="Xrn1 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF03159"
FT DOMAIN 274..599
FT /note="Xrn1 helical"
FT /evidence="ECO:0000259|Pfam:PF17846"
FT DOMAIN 653..834
FT /note="5'-3' exoribonuclease 1 D1"
FT /evidence="ECO:0000259|Pfam:PF18332"
FT DOMAIN 846..1071
FT /note="Exoribonuclease Xrn1 D2/D3"
FT /evidence="ECO:0000259|Pfam:PF18334"
FT DOMAIN 1099..1168
FT /note="5'-3' exoribonuclease 1 SH3-like"
FT /evidence="ECO:0000259|Pfam:PF18129"
FT REGION 1202..1298
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1332..1360
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1375..1407
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1623..1704
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1202..1287
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1379..1407
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1623..1694
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1717 AA; 192990 MW; D25545FB7A535CBF CRC64;
MGVPKFYRWI SERYPCLSEV VKEHQIPEFD NLYLDMNGII HQCSHPNDED VHFRISEEKI
FADIFHYLEV LFRIIKPRKV FFMAVDGVAP RAKMNQQRGR RFRSAKEAED KIKKALDKGE
VLPTEARFDS NCITPGTDFM ARLQEQLKYF VHNKLSNDKL WQNVRVYLSG HETPGEGEHK
IMEFIRSENS QPGHDPNTRH CLYGLDADLI MLGLTSHEPN FSLLREEVRF GGKKSQKRIT
APEETTFHLL HLSLMREYID YEFSALKNQM GSNYDLERVI DDWILMGFLV GNDFIPHLPH
LHINHDALPL LYKTYISVLP SLGGYLNENG NLNLRNFERY MEKLAEFDRE HFSEVFVDLK
WFESKVGNKY LNEAAGLAAE KEAASKDTNK NEHSALSLAA LTSSEQVIGE GKGADEEEEE
DDMFETEFRQ YKRTYYMTKM GVDVVSDEFL AKQAKCYVEG IQWILHYYYH GVQSWSWYYP
FHYAPFLSDI RNISELKLTF DLGKPFMPFQ QLLAVLPAAS MELLPECYRH LMTSERSPII
EYYPLDFKTD LNGKQQEWEA VVLIPFIDER CLLAAMDPCN DKLTKGEKAR NRHTECAVYS
YDHELDFTYT STLPQLFPDI IHCHVRKANI PMDAWQVQLD HVSRRVDRSA LYFCGFPTLQ
HIRHKFYKKK SGVVVFQQSS RGENMMLDIL HSQDGETICD DVAAQVLGNS VFVNWPHLEE
ARIIAVSDGE TKFYLEEPPG VQRVYDRLST PPPTKVTCLS DKEQKEWVKD VQGITEYFLK
RKGIVVNETA VVLYGQLLTG RKYVPKANGV VELEKQWSKQ VLPFAYQTVV KDIKAFYSSL
TCFKSLDELF PPATTVFMVG NPYYGAMGEV QDSQDVIKDG RVRVVFNVPY EPQLEHLIQN
QHKYCVKYSP GYVLASRLGI TSYLVSRFSG SIFIGRGSKK NPCGEQKANV GLNLKFNKKN
EEVPGYTKRT EKEWLYSAAV EELLAEYLDR FCEVFDTVSR NSHDDVFYED DIWPGEDQNG
AEKVTEITSW LKSHPVSSIS RTSCDLQVLD SAIVERIEDA VDKAKVKKST KKVRVTVKPH
LLFRPLEQQQ GVVPDPDAEY RLFDRVVNIR ESFTVPLGLR GTIIGIKGAE REAEVLYEVL
FDEEFAGGLT IRCTSPRGYR LPPCALINLS HGCRVDHTSH KLTAIVKPQP VAGANYNSHR
QLAGLNHSPR SPFVPTQHNN KHGVMKAASQ GNRSSPSKGP IQKQQGKSKD EYSNVWQSLQ
NSGPPNKPPA HWQNSEGNAQ QGKNQHGIKS APPGGIRLLK KNEDANSFFP SQNTANKTTT
EFEDLIASLK ISKGNQQTPP PPVPSQAPAN QSDGPLSPQS FAMKGTLVLK EMLKIDGTGS
GSPSPQETGN TTQSTGQQQN RRRSSKKLAA MMNTPHNDAP MLPTPTPAGP AKAMLSSKVS
ELACVCVGLG MAPPEFSFIR NRQGLVVGQV KLSNGLMVHG PQCQSENDAK EKAAFFALQR
LNSVGSGFPL PPPIYPGVSQ IRPPPIGAMT PVFNQQGGLL LPPQGYGPAP LWGMALPPHH
HQNQPFYGAA GTFPGAQRPQ PATTLPIGSH NQFIPLQVTK KRVSANKKNQ ETREFYSAAQ
IVAKNQSQKA QSQPSGQSLA QSEPQSGKMD QPHQHAANSN PSSSSHPGLL DAVSTTTAAP
HTPPRQNVPA TGHTPGSASK RKHRKLAVNF EAAKVSE
//