GenomeNet

Database: UniProt
Entry: A0A3P8S923_AMPPE
LinkDB: A0A3P8S923_AMPPE
Original site: A0A3P8S923_AMPPE 
ID   A0A3P8S923_AMPPE        Unreviewed;      1717 AA.
AC   A0A3P8S923;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   24-JAN-2024, entry version 21.
DE   RecName: Full=5'-3' exoribonuclease 1 {ECO:0000256|PIRNR:PIRNR006743};
DE            EC=3.1.13.- {ECO:0000256|PIRNR:PIRNR006743};
OS   Amphiprion percula (Orange clownfish) (Lutjanus percula).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Pomacentridae; Amphiprion.
OX   NCBI_TaxID=161767 {ECO:0000313|Ensembl:ENSAPEP00000009248.1, ECO:0000313|Proteomes:UP000265080};
RN   [1] {ECO:0000313|Ensembl:ENSAPEP00000009248.1, ECO:0000313|Proteomes:UP000265080}
RP   NUCLEOTIDE SEQUENCE.
RA   Lehmann R.;
RT   "Finding Nemo's genes: A chromosome-scale reference assembly of the genome
RT   of the orange clownfish Amphiprion percula.";
RL   Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSAPEP00000009248.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|PIRNR:PIRNR006743}.
CC   -!- SIMILARITY: Belongs to the 5'-3' exonuclease family.
CC       {ECO:0000256|ARBA:ARBA00038299, ECO:0000256|PIRNR:PIRNR006743}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   STRING; 161767.ENSAPEP00000009248; -.
DR   Ensembl; ENSAPET00000009501.1; ENSAPEP00000009248.1; ENSAPEG00000006620.1.
DR   GeneTree; ENSGT00670000098080; -.
DR   Proteomes; UP000265080; Chromosome 10.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008409; F:5'-3' exonuclease activity; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000956; P:nuclear-transcribed mRNA catabolic process; IEA:InterPro.
DR   CDD; cd18673; PIN_XRN1-2-like; 1.
DR   Gene3D; 1.25.40.1050; -; 1.
DR   Gene3D; 2.170.260.40; -; 1.
DR   Gene3D; 2.30.30.750; -; 1.
DR   Gene3D; 3.40.50.12390; -; 1.
DR   InterPro; IPR027073; 5_3_exoribonuclease.
DR   InterPro; IPR016494; 5_3_exoribonuclease_1.
DR   InterPro; IPR041385; SH3_12.
DR   InterPro; IPR040992; XRN1_D1.
DR   InterPro; IPR047007; XRN1_D1_sf.
DR   InterPro; IPR041106; XRN1_D2_D3.
DR   InterPro; IPR041412; Xrn1_helical.
DR   InterPro; IPR004859; Xrn1_N.
DR   InterPro; IPR047008; XRN1_SH3_sf.
DR   PANTHER; PTHR12341:SF7; 5'-3' EXORIBONUCLEASE 1; 1.
DR   PANTHER; PTHR12341; 5'->3' EXORIBONUCLEASE; 1.
DR   Pfam; PF18129; SH3_12; 1.
DR   Pfam; PF18332; XRN1_D1; 1.
DR   Pfam; PF18334; XRN1_D2_D3; 1.
DR   Pfam; PF17846; XRN_M; 1.
DR   Pfam; PF03159; XRN_N; 1.
DR   PIRSF; PIRSF006743; Exonuclease_Xnr1; 2.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|PIRNR:PIRNR006743};
KW   Exonuclease {ECO:0000256|ARBA:ARBA00022839, ECO:0000256|PIRNR:PIRNR006743};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PIRNR:PIRNR006743};
KW   Nuclease {ECO:0000256|ARBA:ARBA00022722, ECO:0000256|PIRNR:PIRNR006743};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265080};
KW   RNA-binding {ECO:0000256|PIRNR:PIRNR006743}.
FT   DOMAIN          1..227
FT                   /note="Xrn1 N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF03159"
FT   DOMAIN          274..599
FT                   /note="Xrn1 helical"
FT                   /evidence="ECO:0000259|Pfam:PF17846"
FT   DOMAIN          653..834
FT                   /note="5'-3' exoribonuclease 1 D1"
FT                   /evidence="ECO:0000259|Pfam:PF18332"
FT   DOMAIN          846..1071
FT                   /note="Exoribonuclease Xrn1 D2/D3"
FT                   /evidence="ECO:0000259|Pfam:PF18334"
FT   DOMAIN          1099..1168
FT                   /note="5'-3' exoribonuclease 1 SH3-like"
FT                   /evidence="ECO:0000259|Pfam:PF18129"
FT   REGION          1202..1298
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1332..1360
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1375..1407
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1623..1704
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1202..1287
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1379..1407
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1623..1694
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1717 AA;  192990 MW;  D25545FB7A535CBF CRC64;
     MGVPKFYRWI SERYPCLSEV VKEHQIPEFD NLYLDMNGII HQCSHPNDED VHFRISEEKI
     FADIFHYLEV LFRIIKPRKV FFMAVDGVAP RAKMNQQRGR RFRSAKEAED KIKKALDKGE
     VLPTEARFDS NCITPGTDFM ARLQEQLKYF VHNKLSNDKL WQNVRVYLSG HETPGEGEHK
     IMEFIRSENS QPGHDPNTRH CLYGLDADLI MLGLTSHEPN FSLLREEVRF GGKKSQKRIT
     APEETTFHLL HLSLMREYID YEFSALKNQM GSNYDLERVI DDWILMGFLV GNDFIPHLPH
     LHINHDALPL LYKTYISVLP SLGGYLNENG NLNLRNFERY MEKLAEFDRE HFSEVFVDLK
     WFESKVGNKY LNEAAGLAAE KEAASKDTNK NEHSALSLAA LTSSEQVIGE GKGADEEEEE
     DDMFETEFRQ YKRTYYMTKM GVDVVSDEFL AKQAKCYVEG IQWILHYYYH GVQSWSWYYP
     FHYAPFLSDI RNISELKLTF DLGKPFMPFQ QLLAVLPAAS MELLPECYRH LMTSERSPII
     EYYPLDFKTD LNGKQQEWEA VVLIPFIDER CLLAAMDPCN DKLTKGEKAR NRHTECAVYS
     YDHELDFTYT STLPQLFPDI IHCHVRKANI PMDAWQVQLD HVSRRVDRSA LYFCGFPTLQ
     HIRHKFYKKK SGVVVFQQSS RGENMMLDIL HSQDGETICD DVAAQVLGNS VFVNWPHLEE
     ARIIAVSDGE TKFYLEEPPG VQRVYDRLST PPPTKVTCLS DKEQKEWVKD VQGITEYFLK
     RKGIVVNETA VVLYGQLLTG RKYVPKANGV VELEKQWSKQ VLPFAYQTVV KDIKAFYSSL
     TCFKSLDELF PPATTVFMVG NPYYGAMGEV QDSQDVIKDG RVRVVFNVPY EPQLEHLIQN
     QHKYCVKYSP GYVLASRLGI TSYLVSRFSG SIFIGRGSKK NPCGEQKANV GLNLKFNKKN
     EEVPGYTKRT EKEWLYSAAV EELLAEYLDR FCEVFDTVSR NSHDDVFYED DIWPGEDQNG
     AEKVTEITSW LKSHPVSSIS RTSCDLQVLD SAIVERIEDA VDKAKVKKST KKVRVTVKPH
     LLFRPLEQQQ GVVPDPDAEY RLFDRVVNIR ESFTVPLGLR GTIIGIKGAE REAEVLYEVL
     FDEEFAGGLT IRCTSPRGYR LPPCALINLS HGCRVDHTSH KLTAIVKPQP VAGANYNSHR
     QLAGLNHSPR SPFVPTQHNN KHGVMKAASQ GNRSSPSKGP IQKQQGKSKD EYSNVWQSLQ
     NSGPPNKPPA HWQNSEGNAQ QGKNQHGIKS APPGGIRLLK KNEDANSFFP SQNTANKTTT
     EFEDLIASLK ISKGNQQTPP PPVPSQAPAN QSDGPLSPQS FAMKGTLVLK EMLKIDGTGS
     GSPSPQETGN TTQSTGQQQN RRRSSKKLAA MMNTPHNDAP MLPTPTPAGP AKAMLSSKVS
     ELACVCVGLG MAPPEFSFIR NRQGLVVGQV KLSNGLMVHG PQCQSENDAK EKAAFFALQR
     LNSVGSGFPL PPPIYPGVSQ IRPPPIGAMT PVFNQQGGLL LPPQGYGPAP LWGMALPPHH
     HQNQPFYGAA GTFPGAQRPQ PATTLPIGSH NQFIPLQVTK KRVSANKKNQ ETREFYSAAQ
     IVAKNQSQKA QSQPSGQSLA QSEPQSGKMD QPHQHAANSN PSSSSHPGLL DAVSTTTAAP
     HTPPRQNVPA TGHTPGSASK RKHRKLAVNF EAAKVSE
//
DBGET integrated database retrieval system