ID A0A3P8S9G1_AMPPE Unreviewed; 461 AA.
AC A0A3P8S9G1;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE RecName: Full=Clusterin {ECO:0000256|ARBA:ARBA00020334, ECO:0000256|RuleBase:RU000629};
OS Amphiprion percula (Orange clownfish) (Lutjanus percula).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Amphiprion.
OX NCBI_TaxID=161767 {ECO:0000313|Ensembl:ENSAPEP00000009373.1, ECO:0000313|Proteomes:UP000265080};
RN [1] {ECO:0000313|Ensembl:ENSAPEP00000009373.1, ECO:0000313|Proteomes:UP000265080}
RP NUCLEOTIDE SEQUENCE.
RA Lehmann R.;
RT "Finding Nemo's genes: A chromosome-scale reference assembly of the genome
RT of the orange clownfish Amphiprion percula.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPEP00000009373.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000256|ARBA:ARBA00004514}. Cytoplasmic vesicle, secretory
CC vesicle, chromaffin granule {ECO:0000256|ARBA:ARBA00004248}.
CC Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00004240}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}. Mitochondrion membrane
CC {ECO:0000256|ARBA:ARBA00004346}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004346}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004346}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}. Secreted
CC {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the clusterin family.
CC {ECO:0000256|ARBA:ARBA00010069, ECO:0000256|RuleBase:RU000629}.
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DR AlphaFoldDB; A0A3P8S9G1; -.
DR Ensembl; ENSAPET00000009626.1; ENSAPEP00000009373.1; ENSAPEG00000006738.1.
DR GeneTree; ENSGT00530000063668; -.
DR OMA; QGSKYIN; -.
DR Proteomes; UP000265080; Chromosome 11.
DR GO; GO:0042583; C:chromaffin granule; IEA:UniProtKB-SubCell.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR InterPro; IPR000753; Clusterin-like.
DR InterPro; IPR016015; Clusterin_C.
DR InterPro; IPR033986; Clusterin_CS.
DR InterPro; IPR016014; Clusterin_N.
DR PANTHER; PTHR10970; CLUSTERIN; 1.
DR PANTHER; PTHR10970:SF1; CLUSTERIN; 1.
DR Pfam; PF01093; Clusterin; 1.
DR SMART; SM00035; CLa; 1.
DR SMART; SM00030; CLb; 1.
DR PROSITE; PS00492; CLUSTERIN_1; 1.
PE 3: Inferred from homology;
KW Chaperone {ECO:0000256|ARBA:ARBA00023186};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000265080};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT SIGNAL 1..29
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 30..461
FT /note="Clusterin"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018300744"
FT DOMAIN 32..229
FT /note="Clusterin N-terminal"
FT /evidence="ECO:0000259|SMART:SM00030"
FT DOMAIN 230..454
FT /note="Clusterin C-terminal"
FT /evidence="ECO:0000259|SMART:SM00035"
FT COILED 74..115
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 461 AA; 52662 MW; 5D7E7B9E81FE92CE CRC64;
MLMMMMMMKK KGSKGSLAVV ALLLVSANCL LLPSREDLNQ ISLQGEKYLD KQIENAINGV
KEMKSVMQKS SEDHKKFLDA LEKTKEQKEE AMRTAQEMEA KLAQEEEVCN DTMKALWEEC
KPCLKSTCVK YYSRTCSSGS GLVGRQLEDV LNRTSPFSIW INGEKIDDLM LEGQRQNREF
KDLEEKYTEM ADGVDTIFSD SMKVADHIHD TPPVFFFPNF LSPHIRRSRS VHSLFHDPFH
GFQNLFSPMM GMSRNFFSSM GSMMDIDSDT PPNEDGSVNE DVVITKPFGN GRMTCREIRR
NSAGCFKFRE ECEKCKEIQH IDCSGKRPLE GPLKEELEEA LALTERFTQQ YNSLLKRFEE
QMFNTSSILD MFNRQFGWVS SLANNTQDGI FRVQTVICKD TEEKTDEEDQ PAETSVSVQL
FDAPVLNITV PGDIPWTDPK FSEVVAQEAL DRYKETSVVV K
//