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Database: UniProt
Entry: A0A3P8S9G1_AMPPE
LinkDB: A0A3P8S9G1_AMPPE
Original site: A0A3P8S9G1_AMPPE 
ID   A0A3P8S9G1_AMPPE        Unreviewed;       461 AA.
AC   A0A3P8S9G1;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   24-JAN-2024, entry version 21.
DE   RecName: Full=Clusterin {ECO:0000256|ARBA:ARBA00020334, ECO:0000256|RuleBase:RU000629};
OS   Amphiprion percula (Orange clownfish) (Lutjanus percula).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Pomacentridae; Amphiprion.
OX   NCBI_TaxID=161767 {ECO:0000313|Ensembl:ENSAPEP00000009373.1, ECO:0000313|Proteomes:UP000265080};
RN   [1] {ECO:0000313|Ensembl:ENSAPEP00000009373.1, ECO:0000313|Proteomes:UP000265080}
RP   NUCLEOTIDE SEQUENCE.
RA   Lehmann R.;
RT   "Finding Nemo's genes: A chromosome-scale reference assembly of the genome
RT   of the orange clownfish Amphiprion percula.";
RL   Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSAPEP00000009373.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC       {ECO:0000256|ARBA:ARBA00004514}. Cytoplasmic vesicle, secretory
CC       vesicle, chromaffin granule {ECO:0000256|ARBA:ARBA00004248}.
CC       Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00004240}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC       {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC       {ECO:0000256|ARBA:ARBA00004287}. Mitochondrion membrane
CC       {ECO:0000256|ARBA:ARBA00004346}; Peripheral membrane protein
CC       {ECO:0000256|ARBA:ARBA00004346}; Cytoplasmic side
CC       {ECO:0000256|ARBA:ARBA00004346}. Nucleus
CC       {ECO:0000256|ARBA:ARBA00004123}. Secreted
CC       {ECO:0000256|ARBA:ARBA00004613}.
CC   -!- SIMILARITY: Belongs to the clusterin family.
CC       {ECO:0000256|ARBA:ARBA00010069, ECO:0000256|RuleBase:RU000629}.
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DR   AlphaFoldDB; A0A3P8S9G1; -.
DR   Ensembl; ENSAPET00000009626.1; ENSAPEP00000009373.1; ENSAPEG00000006738.1.
DR   GeneTree; ENSGT00530000063668; -.
DR   OMA; QGSKYIN; -.
DR   Proteomes; UP000265080; Chromosome 11.
DR   GO; GO:0042583; C:chromaffin granule; IEA:UniProtKB-SubCell.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   InterPro; IPR000753; Clusterin-like.
DR   InterPro; IPR016015; Clusterin_C.
DR   InterPro; IPR033986; Clusterin_CS.
DR   InterPro; IPR016014; Clusterin_N.
DR   PANTHER; PTHR10970; CLUSTERIN; 1.
DR   PANTHER; PTHR10970:SF1; CLUSTERIN; 1.
DR   Pfam; PF01093; Clusterin; 1.
DR   SMART; SM00035; CLa; 1.
DR   SMART; SM00030; CLb; 1.
DR   PROSITE; PS00492; CLUSTERIN_1; 1.
PE   3: Inferred from homology;
KW   Chaperone {ECO:0000256|ARBA:ARBA00023186};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265080};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW   Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT   SIGNAL          1..29
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           30..461
FT                   /note="Clusterin"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5018300744"
FT   DOMAIN          32..229
FT                   /note="Clusterin N-terminal"
FT                   /evidence="ECO:0000259|SMART:SM00030"
FT   DOMAIN          230..454
FT                   /note="Clusterin C-terminal"
FT                   /evidence="ECO:0000259|SMART:SM00035"
FT   COILED          74..115
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   461 AA;  52662 MW;  5D7E7B9E81FE92CE CRC64;
     MLMMMMMMKK KGSKGSLAVV ALLLVSANCL LLPSREDLNQ ISLQGEKYLD KQIENAINGV
     KEMKSVMQKS SEDHKKFLDA LEKTKEQKEE AMRTAQEMEA KLAQEEEVCN DTMKALWEEC
     KPCLKSTCVK YYSRTCSSGS GLVGRQLEDV LNRTSPFSIW INGEKIDDLM LEGQRQNREF
     KDLEEKYTEM ADGVDTIFSD SMKVADHIHD TPPVFFFPNF LSPHIRRSRS VHSLFHDPFH
     GFQNLFSPMM GMSRNFFSSM GSMMDIDSDT PPNEDGSVNE DVVITKPFGN GRMTCREIRR
     NSAGCFKFRE ECEKCKEIQH IDCSGKRPLE GPLKEELEEA LALTERFTQQ YNSLLKRFEE
     QMFNTSSILD MFNRQFGWVS SLANNTQDGI FRVQTVICKD TEEKTDEEDQ PAETSVSVQL
     FDAPVLNITV PGDIPWTDPK FSEVVAQEAL DRYKETSVVV K
//
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