ID   A0A3P8SAE7_AMPPE        Unreviewed;       346 AA.
AC   A0A3P8SAE7;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   24-JAN-2024, entry version 18.
DE   SubName: Full=G protein-coupled receptor 180 {ECO:0000313|Ensembl:ENSAPEP00000009050.1};
GN   Name=GPR180 {ECO:0000313|Ensembl:ENSAPEP00000009050.1};
OS   Amphiprion percula (Orange clownfish) (Lutjanus percula).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Pomacentridae; Amphiprion.
OX   NCBI_TaxID=161767 {ECO:0000313|Ensembl:ENSAPEP00000009050.1, ECO:0000313|Proteomes:UP000265080};
RN   [1] {ECO:0000313|Ensembl:ENSAPEP00000009050.1, ECO:0000313|Proteomes:UP000265080}
RP   NUCLEOTIDE SEQUENCE.
RA   Lehmann R.;
RT   "Finding Nemo's genes: A chromosome-scale reference assembly of the genome
RT   of the orange clownfish Amphiprion percula.";
RL   Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSAPEP00000009050.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR   AlphaFoldDB; A0A3P8SAE7; -.
DR   STRING; 161767.ENSAPEP00000009050; -.
DR   Ensembl; ENSAPET00000009300.1; ENSAPEP00000009050.1; ENSAPEG00000006487.1.
DR   GeneTree; ENSGT00940000153981; -.
DR   OMA; DHSCTEK; -.
DR   Proteomes; UP000265080; Chromosome 24.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IEA:InterPro.
DR   GO; GO:0019236; P:response to pheromone; IEA:InterPro.
DR   InterPro; IPR047831; GPR180/TMEM145.
DR   InterPro; IPR019336; GPR180/TMEM145_TM.
DR   PANTHER; PTHR23252:SF29; INTEGRAL MEMBRANE PROTEIN GPR180; 1.
DR   PANTHER; PTHR23252; INTIMAL THICKNESS RECEPTOR-RELATED; 1.
DR   Pfam; PF10192; GpcrRhopsn4; 1.
PE   4: Predicted;
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265080};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        78..98
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        110..131
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        151..171
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        229..251
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        263..284
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        296..317
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          48..312
FT                   /note="GPR180/TMEM145 transmembrane"
FT                   /evidence="ECO:0000259|Pfam:PF10192"
SQ   SEQUENCE   346 AA;  38791 MW;  D3BA161C5DBF90C3 CRC64;
     MTALHAVNID QEEHNQTIPR QPSPTAWQVL YADRYTCQES AVIPSHADLT FTVLLFNADS
     AGNPLEHFSA EEAGLHSFYF LLLLAYFIAC CIYVQPLYQA LRKGGPMHTV LKVLTTALAL
     QGCSALCNYI HLARYSRDGV GLPLMGSLAE FWDMVSQVSM LYMLLSLCMG WTLSRGRKPQ
     SRPLQWEQSP ASTAVAVGGV ITQGVLLLWE QYSESDSEHH SFHAQQSLAG LLLMALRVGL
     ALLLASVLYQ IISTERSTLK RDFYLSFAKG CFLWFLCHPV LILTSTVFNE HQREKVVTIG
     VILCQSISMV ILYQLFLSRS LYWEVSSLSS VSLPLTMSRT NHRGRY
//