ID A0A3P8SAU7_AMPPE Unreviewed; 1409 AA.
AC A0A3P8SAU7;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=ATP-binding cassette, sub-family A (ABC1), member 3b {ECO:0000313|Ensembl:ENSAPEP00000009200.1};
GN Name=ABCA3 {ECO:0000313|Ensembl:ENSAPEP00000009200.1};
OS Amphiprion percula (Orange clownfish) (Lutjanus percula).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Amphiprion.
OX NCBI_TaxID=161767 {ECO:0000313|Ensembl:ENSAPEP00000009200.1, ECO:0000313|Proteomes:UP000265080};
RN [1] {ECO:0000313|Ensembl:ENSAPEP00000009200.1, ECO:0000313|Proteomes:UP000265080}
RP NUCLEOTIDE SEQUENCE.
RA Lehmann R.;
RT "Finding Nemo's genes: A chromosome-scale reference assembly of the genome
RT of the orange clownfish Amphiprion percula.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPEP00000009200.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR STRING; 161767.ENSAPEP00000009200; -.
DR Ensembl; ENSAPET00000009451.1; ENSAPEP00000009200.1; ENSAPEG00000006551.1.
DR GeneTree; ENSGT00940000155289; -.
DR OMA; WKNWIVL; -.
DR Proteomes; UP000265080; Chromosome 14.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR CDD; cd03263; ABC_subfamily_A; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR013525; ABC2_TM.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR026082; ABCA.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR19229:SF250; ATP-BINDING CASSETTE SUB-FAMILY A MEMBER 3; 1.
DR PANTHER; PTHR19229; ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA; 1.
DR Pfam; PF12698; ABC2_membrane_3; 2.
DR Pfam; PF00005; ABC_tran; 2.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000265080};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 22..42
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 229..247
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 253..271
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 291..320
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 332..352
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 359..379
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 435..457
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 464..481
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 831..854
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 875..896
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 916..937
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 949..967
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1011..1030
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 519..752
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT DOMAIN 1084..1317
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
SQ SEQUENCE 1409 AA; 157840 MW; 000C19E0676CA727 CRC64;
MAVIRQFGLL LWKNYLQQKR QILVTLVEIL LPLLFSGILI VLRQKVSSKD FPNATFFDSY
AVDRLPLMLE VQHLQLAYVP GNSSVVRQVA EDVRIRGFET EEQFENYVRT DPRSGKLLAA
VVFQHPFSHD DEPLPLQVSY RLRFTFTPRN APQREKSELN PNSDLDWHTL SLFPLFQLPG
PREQKDNEGG TPGYFREGFL TVQHAVDRAI MHSYNRTAAG SLLQRTRVVL SRFPYPAFIS
DVFILAIQNQ LPLLLVLSFT YTSLNIARAV VQEKERKLKE YMRMMGLSNW LHWSAWFLMF
FLFLSISVFF VTLLLCIQVS PNGAVLTYSD PTLVFVFLLV FTVATINFSF MISAFFTRAN
VAAAAGGFIY FLSYLPYLFL WPRYDQLSHA QKTSACLISN VAMAMGAQLI GMFEGKGAGI
QWSNLFDSVT VDDDFSLAQV LGLLLLDSLL YGLVAWYMEA VFPGEYGVPL PAYFFVLPSY
WCSSPRMALV SEKEEEEDAE KALKGEFIEE EPAGLVSGIK IKHLSKEFKV GNKTRQAVRD
LTLNMFEGQI TVVLGHNGAG KTTTLSMLTG LFPPSSGRAY ISGYDICQDM NLIRRSLGLC
PQHDVLFDNL TVREHLLFYA QLKGFSKDKI PDEVDRIIRI LNLEDKRGAR SKTLSGGMRR
KLSIGIALIG DSKVVMLDEP TSGMDPSARR ATWDLLQGEK RGRTILLTTH FMDEADLLGD
RIAIMAGGEL QCCGSPLFLK NKYGAGYHMV IVKDALCDVS EITRLVHMYV PNATLESSAG
AELSYILPKE STSRFELLFA ELEMNRDELG ITSYGASVTT MEEVFLRGKT GFAIAINLMY
GMASLSSTFA LLLVTESSIK SKHVQQVSGV YLSNFWFSAL LWDLVNFLLP CLLMLVVFKA
FGVKAFVENN HLVDVLLLLL LYGWAVVPLM YLLSFLFSTA ASAYTRLTIF NMISGTATFL
AVTIMTIPGE TGSGVLIFPN YCLGMSFKIC KKYNITYQMN YFSLEEPGVG RFLLAFTLQG
VVYNVLLFVI ELRCFHTAWL TLMLFQVPVV DEAALLPEDR DVAEQRKRVL ECQPVVESMV
GSPLILQEIS KVYNSGESLL AVDRLSLAVG KGECFGLLGF NGAGKTTTFK MLTGDESVTS
GDAYIDGYSV RRDIKKVQQR IGYCPQFDAV LDHMTGRETL SMYARLRGIP EKYVSGCVEN
VLRSLLLEPH ADKLVRSYSG GNKRKLSAGM ALIGGPPVIF LDEPSTGMDP VARRLLWDAV
TRTRESGKAI IITSHSMEEC EALCTRLAVM VNGQFKCLGS PQHLKSKFGS GYTLLAKVHV
EAELEDGDLL LFKDFIESTF PGSQLKDEHQ GMVHYHLTDR TLTWAQVFGT LEAAKEKYHI
EDYCVSQISL EQVFLSFAQF QHCSQSGRK
//
