ID A0A3P8SB86_AMPPE Unreviewed; 934 AA.
AC A0A3P8SB86;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=SLIT-ROBO Rho GTPase activating protein 2 {ECO:0000313|Ensembl:ENSAPEP00000009923.1};
OS Amphiprion percula (Orange clownfish) (Lutjanus percula).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Amphiprion.
OX NCBI_TaxID=161767 {ECO:0000313|Ensembl:ENSAPEP00000009923.1, ECO:0000313|Proteomes:UP000265080};
RN [1] {ECO:0000313|Ensembl:ENSAPEP00000009923.1, ECO:0000313|Proteomes:UP000265080}
RP NUCLEOTIDE SEQUENCE.
RA Lehmann R.;
RT "Finding Nemo's genes: A chromosome-scale reference assembly of the genome
RT of the orange clownfish Amphiprion percula.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPEP00000009923.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3P8SB86; -.
DR STRING; 161767.ENSAPEP00000009923; -.
DR Ensembl; ENSAPET00000010192.1; ENSAPEP00000009923.1; ENSAPEG00000007068.1.
DR GeneTree; ENSGT00950000182824; -.
DR OMA; SPLNCWN; -.
DR Proteomes; UP000265080; Chromosome 6.
DR GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR GO; GO:0072015; P:podocyte development; IEA:Ensembl.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd11955; SH3_srGAP1-3; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR031160; F_BAR.
DR InterPro; IPR001060; FCH_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR035648; srGAP1/2/3_SH3.
DR PANTHER; PTHR14166; SLIT-ROBO RHO GTPASE ACTIVATING PROTEIN; 1.
DR PANTHER; PTHR14166:SF6; SLIT-ROBO RHO GTPASE-ACTIVATING PROTEIN 2-RELATED; 1.
DR Pfam; PF00611; FCH; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF00018; SH3_1; 1.
DR SMART; SM00055; FCH; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS51741; F_BAR; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|PROSITE-
KW ProRule:PRU01077}; Neurogenesis {ECO:0000256|ARBA:ARBA00022902};
KW Reference proteome {ECO:0000313|Proteomes:UP000265080};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 19..324
FT /note="F-BAR"
FT /evidence="ECO:0000259|PROSITE:PS51741"
FT DOMAIN 451..659
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT DOMAIN 708..767
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 181..234
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 817..849
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 878..908
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 181..204
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 211..234
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 878..902
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 934 AA; 105759 MW; 2AE65FCC8C3B4442 CRC64;
MTSPAKFRKD KEIVAEYETQ VKEIRAQLVE QLKCLDQQCE LRVQLLQDLQ DFFRKKAEIE
MDYSRNLEKL AERFLTKTRS TKDHLLKKEQ SILSPVNCWN LLLLQVKRES RDHATLSDLY
LNNIIPRFAQ ISEDSGRLFK KSKEVGVQLQ EDLMKVLNEL YTVMKTYHMY NTDSINAESK
LKEAEKQEEK QMGRSSRQDD RQTPRSPDTL ASIKTDEKPV RRSSVKKIEK MKEKRQAKYT
ENKLKAIKAR NEYLLALEAT NGCVFKYYIH DLSDIIDCCD LGYHASLHRA LRTYLSAEQN
VETSKHTGLE TLEGAAESLE ANGDKQKLME TYNNVFCPPA RFDFQSHMGD TMGVVCAQQP
VEGELLQRCQ QLQSRLSTLK IENEEVKKTM EATLSTIQDM VTVEDYDVSE CFHHSNSMES
VKSTFSESYL SKPSLAKRRA NQQETEQFYF TKLKEFLEGR NLITKLEAKH DLIEKTLGES
KWDCHGRRNS TVRKQVIICL QHEGIFRVSG SQVEVNDIKN AFERGEDPLA GDQNDHDMDS
IAGVLKLYFR GLDHALFPKE VFHDLISCVS MESLQERAVH IKKVLQSLPS KTLIIMRYLF
AFLNHLSQYS EDNMMDPYNL AICFGPTLMS VPEGHDQVSC QAHVNELIKT IIIHHDTIFP
GPQDLQGPIY TIPGAGDDFC DSPHCEPPLV EEPAPDTVSV THNSEDESDP VEAIARFDYT
GRTARELSFK KGASLLLYQR ASDDWWEGRH NGVDGLVPHQ YIVVQDMSDV GRGSPKPDVD
SRDLLEERVS TRGSAASPTG AHVADIYLAN LNKLRKRPEP GNIRRPFRSE SDTTSPGASG
GGGGVRTASL PVGGALVKEA GDKRPVSAHS ILNSVTRHSS LKTKVESPQL RKTTSAGRSK
SFSNHRPLDP EVIGQMEHSS QVLLSFHTCL LLFL
//
