ID A0A3P8SC65_AMPPE Unreviewed; 571 AA.
AC A0A3P8SC65;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE SubName: Full=Myocyte enhancer factor 2D {ECO:0000313|Ensembl:ENSAPEP00000010228.1};
OS Amphiprion percula (Orange clownfish) (Lutjanus percula).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Amphiprion.
OX NCBI_TaxID=161767 {ECO:0000313|Ensembl:ENSAPEP00000010228.1, ECO:0000313|Proteomes:UP000265080};
RN [1] {ECO:0000313|Ensembl:ENSAPEP00000010228.1, ECO:0000313|Proteomes:UP000265080}
RP NUCLEOTIDE SEQUENCE.
RA Lehmann R.;
RT "Finding Nemo's genes: A chromosome-scale reference assembly of the genome
RT of the orange clownfish Amphiprion percula.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPEP00000010228.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR AlphaFoldDB; A0A3P8SC65; -.
DR Ensembl; ENSAPET00000010506.1; ENSAPEP00000010228.1; ENSAPEG00000007314.1.
DR GeneTree; ENSGT00940000159463; -.
DR Proteomes; UP000265080; Chromosome 17.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:InterPro.
DR CDD; cd00265; MADS_MEF2_like; 1.
DR Gene3D; 3.40.1810.10; Transcription factor, MADS-box; 1.
DR InterPro; IPR022102; HJURP_C.
DR InterPro; IPR033896; MADS_MEF2-like.
DR InterPro; IPR002100; TF_MADSbox.
DR InterPro; IPR036879; TF_MADSbox_sf.
DR PANTHER; PTHR11945; MADS BOX PROTEIN; 1.
DR PANTHER; PTHR11945:SF23; MYOCYTE-SPECIFIC ENHANCER FACTOR 2D; 1.
DR Pfam; PF12347; HJURP_C; 1.
DR Pfam; PF00319; SRF-TF; 1.
DR PRINTS; PR00404; MADSDOMAIN.
DR SMART; SM00432; MADS; 1.
DR SUPFAM; SSF55455; SRF-like; 1.
DR PROSITE; PS00350; MADS_BOX_1; 1.
DR PROSITE; PS50066; MADS_BOX_2; 1.
PE 4: Predicted;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000265080};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 1..61
FT /note="MADS-box"
FT /evidence="ECO:0000259|PROSITE:PS50066"
FT REGION 92..116
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 188..267
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 435..571
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 214..247
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 492..506
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 526..540
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 571 AA; 60455 MW; 7170A0D5151AC621 CRC64;
MGRKKIQIQR ITDERNKQVT FTKRKFGLMK KAYELSVLCD CEIALIIFNH ANKLFQYAST
DMDKVLLKYT EYNEPHESRT NADIIETLRK KGFNGCDSPE PDGEDSIDQS PLNDDKYRKT
TEDLDVLFKR YGQSAAPPQT FSMPVTVQAS NQSTLQFSNP GNALVTTSYV TSSSLTDTHL
LSPQQPALQR NTVSPGLPQR PASAGALLGG DLNNSNGGCP SPVPNGYTSA RASPGLLTVS
NGNSLGKVVP AKSPPPPPSP QMVNSRKPDL RVITSQGGKS LMQMNAQRLA AGAQVAQTLT
TPVVSVATPS LLAQGLPFSA MPTAYNTEYQ LTSADITALH ALASPGGLLP TSVSTWQQQQ
AVTQQPQQQQ QQQQQQQQTQ QQQQQQLNLA SLSNLVMWGV DKQSSELSSQ VSSLAANLRP
VTHIPQGAML TVNTNSSVSI KSEPISPGRD RSTPCPPPSS TTPSSTSGGA ILTAPPQYPG
SLLCLEPPTG RSPADSVSSN ASSFEGSDRD DAAGGGGGGG GGNGSTAGAT GPSSRSVPPD
FSPSAELLRA SNDPEQEGGN IKRMRLDAWV T
//
