ID A0A3P8SFT2_AMPPE Unreviewed; 1096 AA.
AC A0A3P8SFT2;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=NACHT domain-containing protein {ECO:0008006|Google:ProtNLM};
OS Amphiprion percula (Orange clownfish) (Lutjanus percula).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Amphiprion.
OX NCBI_TaxID=161767 {ECO:0000313|Ensembl:ENSAPEP00000011473.1, ECO:0000313|Proteomes:UP000265080};
RN [1] {ECO:0000313|Ensembl:ENSAPEP00000011473.1, ECO:0000313|Proteomes:UP000265080}
RP NUCLEOTIDE SEQUENCE.
RA Lehmann R.;
RT "Finding Nemo's genes: A chromosome-scale reference assembly of the genome
RT of the orange clownfish Amphiprion percula.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPEP00000011473.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3P8SFT2; -.
DR STRING; 161767.ENSAPEP00000011473; -.
DR Ensembl; ENSAPET00000011783.1; ENSAPEP00000011473.1; ENSAPEG00000008208.1.
DR GeneTree; ENSGT01070000253760; -.
DR Proteomes; UP000265080; Chromosome 20.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR029495; NACHT-assoc.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR041267; NLRP_HD2.
DR InterPro; IPR041075; NOD2_WH.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR24106; NACHT, LRR AND CARD DOMAINS-CONTAINING; 1.
DR PANTHER; PTHR24106:SF151; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12-RELATED; 1.
DR Pfam; PF14484; FISNA; 1.
DR Pfam; PF13516; LRR_6; 2.
DR Pfam; PF05729; NACHT; 1.
DR Pfam; PF17776; NLRC4_HD2; 1.
DR Pfam; PF17779; NOD2_WH; 1.
DR Pfam; PF15227; zf-C3HC4_4; 1.
DR SMART; SM01288; FISNA; 1.
DR SMART; SM00368; LRR_RI; 5.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR PROSITE; PS50837; NACHT; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000265080};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 148..190
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 301..435
FT /note="NACHT"
FT /evidence="ECO:0000259|PROSITE:PS50837"
FT REGION 1..137
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 654..741
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 8..28
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 38..74
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 84..120
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 664..694
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 703..736
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1096 AA; 125609 MW; 366A70A88D5E673D CRC64;
MSDCEEEEEF PASSRLSMKS DWSRDEPLNF SKEPQPSDTK LTEVHKMSDC EEEEEFPASS
RLSMKSDWSR DEPLNFSKEP QPSDTKLTEV HKMSDCEEEE EFPASSRLSL KSDWSRDEPL
NFSKEPQPSD TKVMKRRGVS VEEQPSCCDR CQDILKDPVS TSCGHWFCRQ CISSYWDQSA
PSGHSSCPQC GERSRTRGGL QTASQSSCGQ NVGLQEVLQE HKMNLTRRCE RVTEGSDEPG
GGTLLNRIYT ELYITEGHSG EADSQHEVGQ LETASKKSLH DTPIRCQDIF KALPEQQRAI
RVVLTNGVAG VGKTFSVLKF TLDWAVGREN QDVSVVVVLP FRELNLIRDE QHSLLTLLHV
FHPTLQKVTA EQLDDCKLLF IFDGLDESRL SLDFTNRKVV SDISQKSSLD VLLVNLMEGN
LLPSALVWIT SRPAAVNEIP PTLVDRLTEV RGFTDNQKEE YFRRRLSDEE RSSTIISHMK
TSKNLHIMCR LPVFCWITAA VLEHMLTTEQ RGELPKSMTE MFSHFLLVQT QRKKNKYHEG
PETSPQELTK ADREVLLKLG RLAFEHLEKG NIMFYQEDLE QCGLDVTETS VLSGFCTQIF
RRECEMFQKP VYCFVHLSIQ EYLAAVYMLH CHTNRKTEVM EKFLGEERKD LYDEEEKEGE
KKKKTTKKKM KKKRKNKKKK KKEKKKKEKK KRKMKKKKGE EEEEEEGEEE EDEEEDEEEE
EGDEEEEEEE EEENTGISSL DAFLDRVMEK SLRSKNGHLD LFVRFLHGLC LESNQRLLGG
LLGRTKNRPE MIQRVINNLK EMKSDEMCPD RSINIFHCLM EMKDLSVHQE IQEFLQSENR
SEKELSDIHC SALAYMLQMS EEVLDELDLK KYNASEEGKL RLIPAVRNCK KAGLSHCDLS
ESECEVVASA LKSNPSHLTE LDLSISHLEF SGGVKYLCDG LQSPNCKLET LRLEACCLSE
ISCDFLISAL KSNPSHLEHL KHLDLSWNDL HDSGVKHLSG FLESPDCILK TLRLEYCRLS
EISCDSLVSA LKSNPSHLEH LDLSINNLRD LGVKRLSGFL ESPDCILRTL GSDIMFSVIQ
SSHLWIEGMQ FVTDQL
//
