ID A0A3P8SHV4_AMPPE Unreviewed; 406 AA.
AC A0A3P8SHV4;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Neutral cholesterol ester hydrolase 1b, tandem duplicate 1 {ECO:0000313|Ensembl:ENSAPEP00000011722.1};
OS Amphiprion percula (Orange clownfish) (Lutjanus percula).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Amphiprion.
OX NCBI_TaxID=161767 {ECO:0000313|Ensembl:ENSAPEP00000011722.1, ECO:0000313|Proteomes:UP000265080};
RN [1] {ECO:0000313|Ensembl:ENSAPEP00000011722.1, ECO:0000313|Proteomes:UP000265080}
RP NUCLEOTIDE SEQUENCE.
RA Lehmann R.;
RT "Finding Nemo's genes: A chromosome-scale reference assembly of the genome
RT of the orange clownfish Amphiprion percula.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPEP00000011722.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the 'GDXG' lipolytic enzyme family.
CC {ECO:0000256|ARBA:ARBA00010515}.
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DR AlphaFoldDB; A0A3P8SHV4; -.
DR STRING; 161767.ENSAPEP00000011722; -.
DR Ensembl; ENSAPET00000012033.1; ENSAPEP00000011722.1; ENSAPEG00000008379.1.
DR GeneTree; ENSGT00940000156699; -.
DR OMA; DSWKLML; -.
DR Proteomes; UP000265080; Chromosome 22.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0052689; F:carboxylic ester hydrolase activity; IEA:InterPro.
DR GO; GO:0006629; P:lipid metabolic process; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR013094; AB_hydrolase_3.
DR InterPro; IPR017157; Arylacetamide_deacetylase.
DR InterPro; IPR033140; Lipase_GDXG_put_SER_AS.
DR PANTHER; PTHR23024; ARYLACETAMIDE DEACETYLASE; 1.
DR PANTHER; PTHR23024:SF671; ZGC:153038-RELATED; 1.
DR Pfam; PF07859; Abhydrolase_3; 2.
DR PIRSF; PIRSF037251; Arylacetamide_deacetylase; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR PROSITE; PS01174; LIPASE_GDXG_SER; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Reference proteome {ECO:0000313|Proteomes:UP000265080}.
FT DOMAIN 106..264
FT /note="Alpha/beta hydrolase fold-3"
FT /evidence="ECO:0000259|Pfam:PF07859"
FT DOMAIN 316..379
FT /note="Alpha/beta hydrolase fold-3"
FT /evidence="ECO:0000259|Pfam:PF07859"
FT ACT_SITE 188
FT /evidence="ECO:0000256|PIRSR:PIRSR037251-1,
FT ECO:0000256|PROSITE-ProRule:PRU10038"
FT ACT_SITE 346
FT /evidence="ECO:0000256|PIRSR:PIRSR037251-1"
FT ACT_SITE 376
FT /evidence="ECO:0000256|PIRSR:PIRSR037251-1"
SQ SEQUENCE 406 AA; 44704 MW; 38B363084B7DB657 CRC64;
MRLRVAGAVL LSAAAYYVYL PLPSGVSEPW KLMLLDALFR SFMQASDVAH ALGVCHRVHL
LNRVVSWVEV VEARSSAAVN VTDWSLGGVP TRVFQPNGGS TPKRGIIYFH GGGWALGSGR
MRSYDLLCRK MAEDLDAVIM SVDYRLAPEA VFPDQYHDAL AASRSFLSAQ VLQRYGIDPD
RLCVSGDSAG GNLAAAVAQK FGSDDTLKVK FKAQALIYPV LQALDFHTPS YQQNQAVPIL
YRPIMARFWL QYLGADSSLE PLLLANNHSS LDQPGISAAA RSRLDWTNLL PAERRKHFRP
VVKETGSAGV MGEVPGLTDV RAAPLLAEQG VLARTPKAYV MTCEFDVLRD DGLMYGRRLQ
DAGVTVTSDH YEDGFHGCMV FAYLPMMSGV GWRSMNSYIR WLDQNL
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