ID A0A3P8SI46_AMPPE Unreviewed; 640 AA.
AC A0A3P8SI46;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Netrin 5 {ECO:0000313|Ensembl:ENSAPEP00000011574.1};
OS Amphiprion percula (Orange clownfish) (Lutjanus percula).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Amphiprion.
OX NCBI_TaxID=161767 {ECO:0000313|Ensembl:ENSAPEP00000011574.1, ECO:0000313|Proteomes:UP000265080};
RN [1] {ECO:0000313|Ensembl:ENSAPEP00000011574.1, ECO:0000313|Proteomes:UP000265080}
RP NUCLEOTIDE SEQUENCE.
RA Lehmann R.;
RT "Finding Nemo's genes: A chromosome-scale reference assembly of the genome
RT of the orange clownfish Amphiprion percula.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPEP00000011574.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00460}.
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DR AlphaFoldDB; A0A3P8SI46; -.
DR Ensembl; ENSAPET00000011884.1; ENSAPEP00000011574.1; ENSAPEG00000008036.1.
DR GeneTree; ENSGT00940000166316; -.
DR Proteomes; UP000265080; Chromosome 23.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR CDD; cd00055; EGF_Lam; 3.
DR CDD; cd03579; NTR_netrin-1_like; 1.
DR Gene3D; 2.40.50.120; -; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 2.10.25.10; Laminin; 2.
DR InterPro; IPR008211; Laminin_N.
DR InterPro; IPR002049; LE_dom.
DR InterPro; IPR001134; Netrin_domain.
DR InterPro; IPR018933; Netrin_module_non-TIMP.
DR InterPro; IPR008993; TIMP-like_OB-fold.
DR PANTHER; PTHR10574:SF435; LAMININ SUBUNIT GAMMA-1; 1.
DR PANTHER; PTHR10574; NETRIN/LAMININ-RELATED; 1.
DR Pfam; PF00053; Laminin_EGF; 3.
DR Pfam; PF00055; Laminin_N; 1.
DR Pfam; PF01759; NTR; 1.
DR SMART; SM00643; C345C; 1.
DR SMART; SM00180; EGF_Lam; 3.
DR SMART; SM00136; LamNT; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 3.
DR SUPFAM; SSF50242; TIMP-like; 1.
DR PROSITE; PS01248; EGF_LAM_1; 1.
DR PROSITE; PS50027; EGF_LAM_2; 2.
DR PROSITE; PS51117; LAMININ_NTER; 1.
DR PROSITE; PS50189; NTR; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00460};
KW Laminin EGF-like domain {ECO:0000256|ARBA:ARBA00023292,
KW ECO:0000256|PROSITE-ProRule:PRU00460};
KW Reference proteome {ECO:0000313|Proteomes:UP000265080};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 37..243
FT /note="Laminin N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51117"
FT DOMAIN 300..362
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 363..412
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 420..554
FT /note="NTR"
FT /evidence="ECO:0000259|PROSITE:PS50189"
FT REGION 542..640
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 542..569
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 595..640
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 330..339
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 363..375
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 365..382
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 384..393
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 396..410
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
SQ SEQUENCE 640 AA; 71722 MW; A5B18448B6A392F7 CRC64;
MIRLVFPFCP QPSLTGSLSS ASFWTSPHDP CYHPDGRPRH CLSEFINAAY GVPVNASHLL
QGPDYDGNIT TLTDLHNPHN LTCWMTHTGP DTGDWVLTLP LGRRFEITYI SLQFCHQGEP
SDPISISVLK SMDYGRTWRP MQHYSSNCFE NFRLPSQTIA KTRHQETEPL CSDPRPLQRQ
RGGMVLAFST LDGRPSSPDF DYSPTLQDWV TATDIRVVFH QPPAFMSPVR APLALSDLQV
GGRCKCNGHA SKCRRDDAGH AVCICEHHTA GPDCDVCEDF YFDRPWHRAT PTHPNPCVAC
ECNGHSNKCR FSMEVFQQSG RRSGGVCQKC RHHTAGRHCQ YCQNGYTRDH SKPLNHRKAC
QPCQCHPLGA VGRWCNQTSG QCLCRDGVTG LRCNRCAPGY KQGRSPLRPC IRKFTASEEC
VSYCQPSQVK VRMNLETYCL KDYVLKVQVK GMERSGPWWQ FSISVQTVFR IGSTSRVRRG
PQSLWVPDRD LGCGCPALHV GRTFLLIGAE EGERGWGPEE SRLVADRSTL ALQWREHWSP
KLRGFRGQDK RGRCPPKSTN NRQHSKEHRG PQSGYIPPHL LTEKDSEPHG GNTHSGKVDE
TQASVASHTL SHTDRQVKST EPTPSAFSTP ALVCSTLNPV
//
