ID   A0A3P8SLG4_AMPPE        Unreviewed;       328 AA.
AC   A0A3P8SLG4;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 20.
DE   RecName: Full=Mitochondrial thiamine pyrophosphate carrier {ECO:0000256|ARBA:ARBA00040836};
DE   AltName: Full=Solute carrier family 25 member 19 {ECO:0000256|ARBA:ARBA00041879};
OS   Amphiprion percula (Orange clownfish) (Lutjanus percula).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Pomacentridae; Amphiprion.
OX   NCBI_TaxID=161767 {ECO:0000313|Ensembl:ENSAPEP00000013278.1, ECO:0000313|Proteomes:UP000265080};
RN   [1] {ECO:0000313|Ensembl:ENSAPEP00000013278.1, ECO:0000313|Proteomes:UP000265080}
RP   NUCLEOTIDE SEQUENCE.
RA   Lehmann R.;
RT   "Finding Nemo's genes: A chromosome-scale reference assembly of the genome
RT   of the orange clownfish Amphiprion percula.";
RL   Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSAPEP00000013278.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: Mitochondrial transporter mediating uptake of thiamine
CC       diphosphate into mitochondria. It is not clear if the antiporter
CC       activity is affected by the membrane potential or by the proton
CC       electrochemical gradient. {ECO:0000256|ARBA:ARBA00037549}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=thiamine diphosphate(in) + thiamine phosphate(out) = thiamine
CC         diphosphate(out) + thiamine phosphate(in); Xref=Rhea:RHEA:73383,
CC         ChEBI:CHEBI:37575, ChEBI:CHEBI:58937;
CC         Evidence={ECO:0000256|ARBA:ARBA00035968};
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC       {ECO:0000256|ARBA:ARBA00006375, ECO:0000256|RuleBase:RU000488}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; A0A3P8SLG4; -.
DR   STRING; 161767.ENSAPEP00000013278; -.
DR   Ensembl; ENSAPET00000013632.1; ENSAPEP00000013278.1; ENSAPEG00000009453.1.
DR   GeneTree; ENSGT00550000074902; -.
DR   OMA; MYVCYGA; -.
DR   Proteomes; UP000265080; Chromosome 14.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0090422; F:thiamine pyrophosphate transmembrane transporter activity; IEA:UniProt.
DR   Gene3D; 1.50.40.10; Mitochondrial carrier domain; 1.
DR   InterPro; IPR002067; Mit_carrier.
DR   InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR   InterPro; IPR023395; Mt_carrier_dom_sf.
DR   PANTHER; PTHR24089:SF59; MITOCHONDRIAL THIAMINE PYROPHOSPHATE CARRIER; 1.
DR   PANTHER; PTHR24089; SOLUTE CARRIER FAMILY 25; 1.
DR   Pfam; PF00153; Mito_carr; 3.
DR   PRINTS; PR00926; MITOCARRIER.
DR   SUPFAM; SSF103506; Mitochondrial carrier; 1.
DR   PROSITE; PS50920; SOLCAR; 3.
PE   3: Inferred from homology;
KW   Antiport {ECO:0000256|ARBA:ARBA00022449};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW   ProRule:PRU00282}; Reference proteome {ECO:0000313|Proteomes:UP000265080};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW   ProRule:PRU00282};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU000488}.
FT   REPEAT          13..106
FT                   /note="Solcar"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
FT   REPEAT          116..202
FT                   /note="Solcar"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
FT   REPEAT          213..308
FT                   /note="Solcar"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
SQ   SEQUENCE   328 AA;  36300 MW;  8B6CEBFC1B5322BB CRC64;
     MVGYDPGSQG AAVTSEEAAV AGSAAGMVTR ALVSPFDIIK IRFQLQIEHL SSQRPEGKYW
     GLFQASRCIR SEEGLSAFWK GHIPAQLLSI CYGAVQFASF EFLTEMVHKS TAYDSQTSGV
     HFVCGGLAAC SATVFCQPLD TLRTRFAAQG EPKVYRNLRH AVSTMWRSEG MLVFYRGLSP
     TLMAVFPYAG LQFFFYNVFK KLLPPPPKAG NSGGNLRSLI CGSGAGMISK TLTYPFDLFK
     KRLQVGGFEA ARAHFGQVRS YSGLMDCMLR IAKEEGVRGF FKGLSPSLLK AALSTGFTFF
     WYEFFLNVMH DVKERRRTNG LAKDLEDR
//