ID A0A3P8SM51_AMPPE Unreviewed; 3956 AA.
AC A0A3P8SM51;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Dynein, axonemal, heavy chain 12 {ECO:0000313|Ensembl:ENSAPEP00000013170.1};
GN Name=DNAH12 {ECO:0000313|Ensembl:ENSAPEP00000013170.1};
OS Amphiprion percula (Orange clownfish) (Lutjanus percula).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Amphiprion.
OX NCBI_TaxID=161767 {ECO:0000313|Ensembl:ENSAPEP00000013170.1, ECO:0000313|Proteomes:UP000265080};
RN [1] {ECO:0000313|Ensembl:ENSAPEP00000013170.1, ECO:0000313|Proteomes:UP000265080}
RP NUCLEOTIDE SEQUENCE.
RA Lehmann R.;
RT "Finding Nemo's genes: A chromosome-scale reference assembly of the genome
RT of the orange clownfish Amphiprion percula.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPEP00000013170.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
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DR STRING; 161767.ENSAPEP00000013170; -.
DR Ensembl; ENSAPET00000013521.1; ENSAPEP00000013170.1; ENSAPEG00000008904.1.
DR GeneTree; ENSGT00940000154280; -.
DR OMA; CIEWQRY; -.
DR Proteomes; UP000265080; Chromosome 8.
DR GO; GO:0005930; C:axoneme; IEA:UniProt.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR PANTHER; PTHR45703:SF1; DYNEIN HEAVY CHAIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000265080}.
FT DOMAIN 1267..1406
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 1902..2050
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT REGION 744..766
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 2745..2807
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 746..764
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3956 AA; 450813 MW; 1A84D1CE0DFFB268 CRC64;
MATPPDVFKA TPVQGLPKFP VLPPIGGTQH LGDIEHAIAV KEEIVKKMEA QKKLLRHRKS
KVQQEQLHLI CLVRSGKEGY VYFPVLNLTH EAILFFFLLR LSYFILYYLQ MNYMFIRQCV
ETRPLAPIQQ HWLDSIVARV PSKLRKSPET NKLLQEVCME VSDEFRSMMV KHTGIGSFLY
CKNVKGQSSE KQSEILDFST PWHGSFIRNR RIIKAHLHIL HPVMQTMLDI GYTTFSPLVL
VDFSGFRASG PVDCKSLQNK MAVECKRTED RIMNTWFPKI IHLLTNKETL NGVKEQKLDS
FYNCASTLIS NQLKSLLHTS VEEFASVFHP SNHHCLPIFR MALTFDDEKM EIYPTLQDLE
LAVFEILNVQ TVQSWLAQTT SSFVDAKVAD HILAQARVTV KDAVRKNLEE PDKHFQSYVE
SYDWLANGTA QAQVKKFMEE EHSFDEYTKF RALTKEIVSL PSKARFTMVH LDCEELKQGL
ANKAKTYAEM LLNKLVTSHR ELNLQICNEF ETIREKALKV PENTEQMAEM DEYINFTKTK
GSAELTEKIK EAHCRLDYLL NAHIIDPEDL ELNSTVFLWP KNILDVFELS DEVMQKAKKE
GEQELNAKRE QLIVQLEKLG HRIEEFPYCS ELDMMQQYVA DVRLVQKFLQ EVEDNIVLIN
KEEAFHKMEP TSYPEVLVIK ESTEPYQKLF GFVLKWQHTE NGWMNGSFQD LDGETMEVKV
DEFFREGFKM LKFFQQKQNK AAQEMEKISG TKRKPSEDDP KKQESPTITL CSTIMEQIKE
FKEHIPLVSI LCNPGIRTRH WDQMSAIVGY NLNPESGTTL QKVLKQNFAP YLNEFESISA
AASKEFALEK AMQAMVHVWD ETSFHHQPYR ETGVSVLTAL DDIQTVLNDQ IVKTQTMRGS
PFIKPFENEI KSWEERLLRI QDTIDEWLKV QSQWLYLEPI FSSQDIMQQI PEEGRLFQTV
DRNWREVMRH CVKDPKILPA TSLPGLLEKL QDSSALLDNI MKGLNAYLEK KRLFFPRFFF
LSNDEMLEIL SETKDPLRVQ PHLKKCFEGI SKLDFLPNLD IQAMYSSEGE CVPLIQHIST
SEAKGAVEKW LVQVEDVMLR SVRDVIARSR VAYAQTARNQ WVKEWPGQVV LCTSQIFWTL
EVHEAISAGA DGLKNYYKQL QSQLNDIVEL VRGKLPKQTR ITLGALVTID VHARDVVMEL
IEKGVSHETD FQWLAQLRYY WSNDNVRVRI INCDVKYAYE YLGNSPRLVI TPLTDRCYRT
LIGAFYLNLG GAPEGPAGTG KTETTKDLAK ALAVQCVVFN CSDGLDYLAM GKFFKGLASS
GAWACFDEFN RIELEVLSVV AQQVLCIQRA IELKLEYFDF EGTMLKLNPN CFVSITMNPG
YAGRSELPDN LKVLFRTVAM MVPNYALIAE ISLYSYGFLN AKPLSVKIVM TYRLCSEQLS
SQFHYDYGMR AVKAVLVAAG NLKLKYPDEN EDILLLRSIK DVNEPKFLSH DIPLFNGITS
DLFPGISLPK ADYKLFLEAA EECCKNHNVQ PTEVFLQKMI QTYEMMIVRH GFMLVGEPFA
GKTKVLHVLA DALTLMNERG DGLEEKVIFR TLNPKSITMG QLFGQFDLVS HEWTDGIVAN
TFREFASADT PYRKWVVFDG PIDTLWIESM NTVLDDNKKL CLMSGEIIQM SSQMSLIFEA
MDLSQASPAT VSRCGMIYME PSQLGWNPLV ISWMNTLPDV LQTADCRSLL LELFHWLVPP
ALTMLRKHCR EVVSTSDSNT VLSLCRLFEM LLTEPVKTEP GDKNIRTWIM AAFAFSLVWS
VGGSCDADSR EKFSEFVRVT VSGKTKEHQI PETVGKWECP IDEKGLIYDY FYEFKGKGNW
VHWNDAIKSV NLGDKNTKVQ EIIVPTIDTV RYTYLMDLCI SYGTPSLFVG PTGTGKSLYV
KEKLMNNLDK DCYLPFFINF SARTSANQTQ NIIMSRLDKR RKGVFGPPIG KKCVIFVDDM
NMPALEQFGA QPPVELLRQY IDHGNWYDLK DTSGITLVDL QLISAMGPPG GGRNAVTSRF
LRHFNIFSIN AFSDDTMVCI FSNIVAFYLK NNEFPPEYFT VGSQIVTATM EVYKRAMENL
LPTPAKSHYT FNLRDFSRVI QGCLLLKKES LENKRTVIRL FVHEVFRVYY DRLVDDKDRA
WLYKLMNSIL KDHFKESFDQ VFDHLKQGSK EDMRNLLFGD YMNPELEDDE RLYTEVPSMD
TFAQVVESCL DEYNQMHKNR MHLVIFRYVL EHLSRISRVL KQPGGNALLV GVGGSGRQSI
TRLATSMAHM TMFQPEISKS YGMTEWRDDL KMLLKNAGVK GQKTVFLVTD AQIKDEAFLE
DVDSVLNTGE VPNLFAIDEK QEIMESLRPI AQAGNKSLEL SPLTLFAFFV ARCRENLHIV
VAFSPIGDAF RNRLRQFPSL INCCTIDWYQ PWPEEALERV ANSFLESLEM SENERREVIP
ICKTFHTSVK QLSQRFLSEL GRHNYVTPTS YLELIAAFRL LLTQKRQTVM KAKQRYTDGL
DKLAFAESQV NEMKKELVDL QPKLEQAKID NTKMMKVIEV ESVEVEAKSK IVRVDEEAAT
VEANEARALK NECESDLAEA IPALEAALSA LNTLKPSDVT IVKAMKNPPS GVKLVMAAVC
VMKDLKPDKI PDPAGTGKKI FDFWGPSKKL LGDMNFLRDL KEYDKDNIPV PVMQKIRSEY
MTNPDFDPSV VVKASSAAEG LCKWIKAMEV YDRVAKVVAP KKANLAEAQE SLAATMALLD
QKRAELKEVE DRLAALQKTF EEKTEEKAQL EFQVDLCARK LERAEKLIGG LGGEKTRWSE
AADDLQNTYD NLTGDVLISA GVIAYLGAFT AGFRQDCTKL WTKLCQSKNI PSSDDFSLSK
TLGDPIKIRA WNIAGLPSDS FSIDNGVIVS SSRRWPLMID PQGQANKWVK NSEKDNNLSV
IKLTDGDCMR TLENCIQFGT PLLLENVGEE LDPSLEPLLL KQTFKQGGVD CIRLGESVIE
YSSNFRFYIT TKLRNPHYLP ELATKVSLLN FMITPEGLED QLLGIVVAKE RPELEEERNA
LILQSAANKR RLKEIEDEIL ETLQSSEGNI LEDECAIQIL DSAKLMSNEI TKKQQIAEKT
EIKIAESREG YRAIAKHSSI LFFSIADLTS IDPMYQYSLS WFVNLYINSI QNSNKSKILE
RRLQHLIDHF TYNLYCNVCR SLFEKDKLLF SFLLCCKLLL AKEEIEYSDF MFLLTGGVGL
QNTIANPDPS WLQDKSWDEI CRANELPGLQ GIKEAFIKSL GDFKPIYDSK EPCNVALPAP
WCEKLNDLQK MIIVRCLRPD KIVPAVTKYV TGSLGKRFVQ PPPFDLSKSY LDSNCTTPLV
FVLSPGADPM ASLLKFASDK NMGGAKFQSI SLGQGQGPIA AKMISTAMQD GTWVCLQNCH
LAVSWMSTLE KICEDFSLAT CHQDFRLWLT SYPSSKFPVT ILQNGVKMTN EPPTGLRLNL
LQSYLSDPVS DPDFFNNCPN KEMIWEKLLY GLCFFHALVQ ERKKFGPLGW NIPYGFNDSD
LRISIRQLQL FVNEYDEVPL EAITYLTGEC NYGGRVTDDW DRRLLMTILA DFYNKDIIVT
FRYPFSPSGE YFSPPKSAYD DYVLFIKELP FSQHPEVFGM HENVDISKDL QQTKVLFDSL
LLTQGGGAKG GATSGSDNTL YDIANDILTK LPVNFDTEAA LLKFPVLYEE SMNTVLVQEM
ERYNVLCSTI RVSLQNLLKA IKGLVVMDAE LEAVAGSLMV GKVPEKWAKR SYPSLKPLGS
YITDFLSRLK FLQVWYDTSK PSVFWLSGFF FTQAFLTGAM QNYARKYQIP IDLLGFDFEV
LPIDESNTAP EDGVYINGLF LDGARWDKIS GALAEQLPKV LFDLMPIIWI KPTEKKSSDL
PKKLYVCPLY KTSERKGTLS TTGHSTNFVI SMMLPIDKRP QHWIKRGVAL LCQLDD
//
