ID A0A3P8SMF7_AMPPE Unreviewed; 2859 AA.
AC A0A3P8SMF7;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Multiple EGF-like-domains 8 {ECO:0000313|Ensembl:ENSAPEP00000013623.1};
GN Name=MEGF8 {ECO:0000313|Ensembl:ENSAPEP00000013623.1};
OS Amphiprion percula (Orange clownfish) (Lutjanus percula).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Amphiprion.
OX NCBI_TaxID=161767 {ECO:0000313|Ensembl:ENSAPEP00000013623.1, ECO:0000313|Proteomes:UP000265080};
RN [1] {ECO:0000313|Ensembl:ENSAPEP00000013623.1, ECO:0000313|Proteomes:UP000265080}
RP NUCLEOTIDE SEQUENCE.
RA Lehmann R.;
RT "Finding Nemo's genes: A chromosome-scale reference assembly of the genome
RT of the orange clownfish Amphiprion percula.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPEP00000013623.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR STRING; 161767.ENSAPEP00000013623; -.
DR Ensembl; ENSAPET00000013986.1; ENSAPEP00000013623.1; ENSAPEG00000009579.1.
DR GeneTree; ENSGT00940000160262; -.
DR OMA; PVCQWCD; -.
DR Proteomes; UP000265080; Chromosome 7.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR GO; GO:0042074; P:cell migration involved in gastrulation; IEA:Ensembl.
DR GO; GO:0007368; P:determination of left/right symmetry; IEA:Ensembl.
DR GO; GO:0055113; P:epiboly involved in gastrulation with mouth forming second; IEA:Ensembl.
DR CDD; cd00041; CUB; 1.
DR CDD; cd00054; EGF_CA; 1.
DR CDD; cd00055; EGF_Lam; 3.
DR Gene3D; 2.120.10.80; Kelch-type beta propeller; 4.
DR Gene3D; 2.10.25.10; Laminin; 7.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 2.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR024731; EGF_dom.
DR InterPro; IPR011043; Gal_Oxase/kelch_b-propeller.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR015915; Kelch-typ_b-propeller.
DR InterPro; IPR002049; LE_dom.
DR InterPro; IPR002165; Plexin_repeat.
DR InterPro; IPR016201; PSI.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR PANTHER; PTHR46093; ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 5; 1.
DR PANTHER; PTHR46093:SF17; MULTIPLE EGF-LIKE-DOMAINS 8; 1.
DR Pfam; PF00431; CUB; 1.
DR Pfam; PF12947; EGF_3; 1.
DR Pfam; PF07645; EGF_CA; 1.
DR Pfam; PF13415; Kelch_3; 1.
DR Pfam; PF13418; Kelch_4; 2.
DR Pfam; PF00053; Laminin_EGF; 4.
DR Pfam; PF01437; PSI; 1.
DR SMART; SM00042; CUB; 1.
DR SMART; SM00181; EGF; 11.
DR SMART; SM00179; EGF_CA; 2.
DR SMART; SM00180; EGF_Lam; 4.
DR SMART; SM00423; PSI; 9.
DR SUPFAM; SSF57196; EGF/Laminin; 2.
DR SUPFAM; SSF50965; Galactose oxidase, central domain; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 2.
DR SUPFAM; SSF117281; Kelch motif; 2.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 2.
DR PROSITE; PS00010; ASX_HYDROXYL; 2.
DR PROSITE; PS01180; CUB; 2.
DR PROSITE; PS00022; EGF_1; 3.
DR PROSITE; PS01186; EGF_2; 4.
DR PROSITE; PS50026; EGF_3; 3.
DR PROSITE; PS01187; EGF_CA; 2.
DR PROSITE; PS01248; EGF_LAM_1; 3.
DR PROSITE; PS50027; EGF_LAM_2; 2.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Kelch repeat {ECO:0000256|ARBA:ARBA00022441};
KW Laminin EGF-like domain {ECO:0000256|ARBA:ARBA00023292,
KW ECO:0000256|PROSITE-ProRule:PRU00460};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000265080};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..2859
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018205685"
FT DOMAIN 27..137
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 168..201
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1086..1127
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1171..1218
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1219..1269
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1271..1412
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 2131..2173
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DISULFID 27..54
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00059"
FT DISULFID 172..182
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 191..200
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1189..1198
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1241..1250
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1253..1267
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
SQ SEQUENCE 2859 AA; 311499 MW; C75E836FA93EE575 CRC64;
MASPLPVSFI LVVLLVAESP MCQAGDCKGH RQVFRGPPGY VTDGPGNYSV NGNCEWLIKA
PSNSHRIVLN FTFMDTECTY DYLFVYDGDS YQSPLLASLS GNTLPQPIEA KSGKMLLHLF
SDANYNLLGF NATYTFSLCP GACGGHGRCD SSTSKCHCHQ GWGGASCTTP LCAQACSVNG
HCDKKGERCL CNPGFLGHSC QLGLHDDSGA GQWWHVSEGN PYTPPRTGSA GVYLSSTGAM
YLFGGFDLNR ALGDLIKYNF TSNQWESRSY GHSPVARHSH TAVEYMGNMV IFGGELANGS
LASDVWMYRP LQDDWQQLGF SHSHGAPRLA NHAAAVVDSY LYVFGGRTEE DMFSSTLYRF
GLHGSGRWET VHPTGGKPPA TAGHSMVFHS PSRTLLVYGG HRPTTARFSV RVNNTDVFHV
NRRFWTSFRS RFPATGPRER AFHSATVIGN YMVVYGGNVH IHYQEEKCYD EEIFLYHLGC
HQWVSTGERC LRSMGGRYSH VAAVMEGRVL LVAGGYSGVA RGDLVAYKVP LFVSSDQGDR
DAVCAEALDE SMCLKNPECS WCEGRCREYQ PTNPCGSTGC LGLARFLSDC QSCLVFSGTP
PPLARAPGDF GWCVQNESCL PVSERSACRV DQISGAYGWW GERTLFLTSL HSCRTENYVP
GLHLLTFQHP RNDSQPDKVS ILRSTTIILS PTTEMDVALQ FRGFIHPLWG GPPPAPPPTE
TVSMWARIQR LHFDARMASG PNSSQLEVVG HWAAQQEKEL KLLARTDGSR LFSNLTRGNH
YLVQAEGYLN NSGSGQTSEM ALIWNRTLPG GSEISFLFLE PYRSGSCSGY MSCLACLSDQ
SCGWCPSLSR CLLRESPDLE PCPEVDKGDG KGEGQRHLLL APQHCTLCEE YRDCSACTQD
PYCEWQINSS KKGDYQCSRR GRLDGSIRDS RGCPKVCNQR KTCGECLSNS SQCAWCESAQ
ACFYFAAYLT KYPYGECRDW YDSVHSVPQC KQCSALNTCT DCLRTFQCGW CGDYNNPTIG
KCLRGDWAGM DDPSVYNCSV AVAEARAANP EPQTSAPPRP LEMEMELEHL DDEEQDAIWS
YPTCPDVEEC RLGLHNCHPF ATCINTPTSY ECHCERGYTG DGTLHCNQTC YNECREGQCS
GSPRFECECS LGWTSDPATL VLSGVECDVD CGCNFHSTCI TAPGICDECQ DWTTGNHCEH
CRPGSFGSAL AGGGGCVPCE CNGHGDPLRG YCHNQTGQCY CTHNTQGPHC ESCLPGYYGD
PRNNGTCYRQ CQGRSVLLSS TSSSAMPLSS SLGWRSGTEG KGGLSHCLWV LSVTENLAPC
LPRQFCPPVA LTLHPDSHTH CKSSYVYVFD GLPRFLGNGV VHSDHNLIGA FCGTTRTQPV
TVEATSGVIS VYFEANVSSN KPQGFNASFW VRRCQQSSDE GEERSSVCPG GGQCQGGLCQ
CPQGYGGPHC NRPMCPQDCG IAEGRGACNI SLGVCVCSDS WAGSDCSVPR DSNSLVWETL
LDTQLTVNQA HRFLHRMGHS LVSGPQGNLW MYGGLSLSEG ILGNVYRYSV SEHRWTQMLT
SSVEEGSTPG ARYHHASALL TSHDFGSGSY GASHNFMLVV GGVTQNGVAM DTWSLNLSSL
VWREHKSTVL PPVAGHTLTV RRDASVLLIG GYSPENGFNH HLLEFNPHSG NWTVALHTGT
PPTGLYGHSA VYHEQTDAIY VFGGYRFHVE TVEPSGELYS LYYPNLTWSL LVPSQGSKPL
SRFFHAAALI KDTMVIVGGR TEAEDYSNSV SLYQINCNTW IQPASAVGDP VNRSVSLAMT
SWGGRLFLSG GFNGVTLGRL LTLSVPSDPC ALLPTPEACN TTTGSCIWCR GTCASSDIAE
RMGCFTGQSP CSPTPRQPDQ CRRLKTCSEC LARHPKTFSS SSQSALQCKW CTNCPEGACI
SSSVSCTSEH DCRINQREIF LSSNCTETSC EASDCPKCTA SGKCMWTRQF KRTGETRRIL
SVNPTYDWTC FSYALLNVSP MQVESSPPLP CPPPCHSLHN CSLCLGSRGS DGGWQHCVWS
MTLQQCMSPS FVPLRCEAGQ CGRLLSGGDS CSPQCSQLTQ CSQCIARPQC GWCATRGGNG
AGRCLQGGLD GVSEGVCPLR NSSWSFLHCP EEDECANGHH HCNSTQDCHD LSQGYHCTCK
QGYILNSVSG QCEPVCAQGC VNGTCVSPGV CQCHFGFVGD NCSSQCSCNK HSNCAGVNKP
DVCLECHNNT IGKHCEKCKP LFVGSAKGGG TCHPCREFCK GNSAVCLSRD EHKKALENPR
LFPLDPNTIQ KWISEGPTED NAMCVNCQNN SVGDKCESCL SGYFLLQGKC EKCQCNGHAD
TCNEHDGTGC PCQNNTETSS CLSSPQSDRK DCYRQQCAKC KDSFNGTPVN GRQCYRQFNV
DTECCFDPTS QTNCFHFPTI RNLPKGRTVF FAAQPKFTNV DIRVTIDVTF GEVEVYVSNS
HDTFIVDVDR YTGIHAIKIE EESVTRGTTT GVDKDSPPSP IKVFANASSS LGGPVLSHNP
LQLQAKPSGS DREIREERAE GLITYITVWK PQTVLIVRGV RDRVVITFPH EVHSLKSSRF
YIALRGVGTD EKQGESQGLL FLRQDQAHID LFVFFSVFFL QFLDFRREQR RHIQEMTKMA
SRPFAKLTIY LEPEEPQLIY LPSAGGGVGG STVSLAHSRT SKLGGVVVGQ RGRAGAVSYK
HDAGSGPTAH HHHHLTLGGG GNSGQHLPLH YLNTHHYAST TTGTPASHHH HPSTYSGYQH
FCRSDPFLSQ LMGFSYSSFK VGPITLEPTD DGMAGVATVL FQLPGGVLAP NRACLGSALV
TLRQNLQEYC GHGSGGGHPG VGAGRKGLLG HQHLTTMAM
//