ID A0A3P8SMQ7_AMPPE Unreviewed; 899 AA.
AC A0A3P8SMQ7;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Signal peptide, CUB domain, EGF-like 2 {ECO:0000313|Ensembl:ENSAPEP00000013399.1};
OS Amphiprion percula (Orange clownfish) (Lutjanus percula).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Amphiprion.
OX NCBI_TaxID=161767 {ECO:0000313|Ensembl:ENSAPEP00000013399.1, ECO:0000313|Proteomes:UP000265080};
RN [1] {ECO:0000313|Ensembl:ENSAPEP00000013399.1, ECO:0000313|Proteomes:UP000265080}
RP NUCLEOTIDE SEQUENCE.
RA Lehmann R.;
RT "Finding Nemo's genes: A chromosome-scale reference assembly of the genome
RT of the orange clownfish Amphiprion percula.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPEP00000013399.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR AlphaFoldDB; A0A3P8SMQ7; -.
DR Ensembl; ENSAPET00000013757.1; ENSAPEP00000013399.1; ENSAPEG00000009266.1.
DR GeneTree; ENSGT00940000153185; -.
DR OMA; CVETKDP; -.
DR Proteomes; UP000265080; Chromosome 1.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR CDD; cd00041; CUB; 1.
DR CDD; cd00054; EGF_CA; 3.
DR Gene3D; 2.10.25.10; Laminin; 9.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 1.
DR Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 3.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR024731; EGF_dom.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR InterPro; IPR011641; Tyr-kin_ephrin_A/B_rcpt-like.
DR PANTHER; PTHR24046; SIGNAL PEPTIDE, CUB AND EGF-LIKE DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR24046:SF3; SIGNAL PEPTIDE, CUB AND EGF-LIKE DOMAIN-CONTAINING PROTEIN 2; 1.
DR Pfam; PF12662; cEGF; 1.
DR Pfam; PF00431; CUB; 1.
DR Pfam; PF12947; EGF_3; 1.
DR Pfam; PF07645; EGF_CA; 1.
DR Pfam; PF07699; Ephrin_rec_like; 3.
DR Pfam; PF14670; FXa_inhibition; 4.
DR SMART; SM00042; CUB; 1.
DR SMART; SM00181; EGF; 10.
DR SMART; SM00179; EGF_CA; 7.
DR SMART; SM01411; Ephrin_rec_like; 3.
DR SUPFAM; SSF57196; EGF/Laminin; 3.
DR SUPFAM; SSF57184; Growth factor receptor domain; 4.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 3.
DR PROSITE; PS01180; CUB; 1.
DR PROSITE; PS01186; EGF_2; 5.
DR PROSITE; PS50026; EGF_3; 4.
DR PROSITE; PS01187; EGF_CA; 3.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Reference proteome {ECO:0000313|Proteomes:UP000265080};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..899
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018156335"
FT DOMAIN 27..67
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 110..146
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 275..315
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 316..354
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 711..823
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DISULFID 320..330
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 899 AA; 100288 MW; 9A1E2E359C309E53 CRC64;
PPLTRTRTHA LILVLFQTRA HMLKWISSDP CAEGSDGCHI DAICQTTQGS YKCTCKAGFK
GDGKHCEDID ECDLEYNGGC VQECNNIPGN YRCTCYDGFN LAHDGHNCLD VDECKFNNGG
CQHTCVNTMG SYECRCKEGF FLSDNQHTCI HRSVEGLNCM NKEHGCAHIC KETPKGGVAC
ECRPGFELAR NQRGCILTCN HGNGGCQHMC EDTENGPICK CHVRYTLQPD KRSCVETCAV
NNGGCDCTCK DTSTGVRCSC PVGFTLQPDG KTCKDIDECE LHNGGCDHFC RNTIGSFECN
CRKGFKLLTD ERSCQDIDEC FFERTCDHTC VNSPGGFQCL CNKGYTMYGL AHCGDINECS
VNNGGCEQGC ENTMGGFECF CRPGYKLHWN KKDCIGKSVP LPYMRGTTAE RCCPVSLEIV
FLFTENVQFS YVSLRCTSSG QRMRSRHGRK AGEEDGSSIT AEFELDVNLE EVTAESCDLN
CVRRRSEKRL RKTIRTLRKS INREQFHLHF AGADYELSKG QPAELPGRCV AGQVLVGRKC
VSCSVGTYFD GDQGRCVLCP AGTYQDEEGQ MSCEVCPGPE GREVSKVVGA RNMSECGGQC
SPGQYSHDGF IPCLSCPLGT YQPEVGRTSC FPCGGNLVTK RSGAVTFQEC ETKVQCSPGH
YYNTSTHRCI RCPMGTYQVE FGQNYCMACP GNTTTDFDGS TNIMQCKNRQ CGGELGDFTG
YIESPNYPGN YPANVECTWT INPPPKRRIL IVVPEIYLPI EDECGDYLVM RKSSLSNSVT
TYETCQTYER PIAFTSRSKR LWIQFRSNEG NSGKGFQVPY VTYDEDYQEL IEDIVRDGRL
YASENHQEIL KDKKLMKALF DVLAHPQNFF NYTAQESREM FPKSFIRFLR SKVLRFLRP
//
