ID A0A3P8SMU2_AMPPE Unreviewed; 646 AA.
AC A0A3P8SMU2;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE SubName: Full=Inositol polyphosphate-5-phosphatase E {ECO:0000313|Ensembl:ENSAPEP00000013440.1};
OS Amphiprion percula (Orange clownfish) (Lutjanus percula).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Amphiprion.
OX NCBI_TaxID=161767 {ECO:0000313|Ensembl:ENSAPEP00000013440.1, ECO:0000313|Proteomes:UP000265080};
RN [1] {ECO:0000313|Ensembl:ENSAPEP00000013440.1, ECO:0000313|Proteomes:UP000265080}
RP NUCLEOTIDE SEQUENCE.
RA Lehmann R.;
RT "Finding Nemo's genes: A chromosome-scale reference assembly of the genome
RT of the orange clownfish Amphiprion percula.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPEP00000013440.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3P8SMU2; -.
DR STRING; 161767.ENSAPEP00000013440; -.
DR Ensembl; ENSAPET00000013798.1; ENSAPEP00000013440.1; ENSAPEG00000009581.1.
DR GeneTree; ENSGT00940000158199; -.
DR OMA; HADYKLR; -.
DR Proteomes; UP000265080; Chromosome 5.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004445; F:inositol-polyphosphate 5-phosphatase activity; IEA:InterPro.
DR GO; GO:0046856; P:phosphatidylinositol dephosphorylation; IEA:InterPro.
DR CDD; cd09095; INPP5c_INPP5E-like; 1.
DR Gene3D; 3.60.10.10; Endonuclease/exonuclease/phosphatase; 1.
DR InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR InterPro; IPR042478; INPP5E.
DR InterPro; IPR000300; IPPc.
DR PANTHER; PTHR46625; 72 KDA INOSITOL POLYPHOSPHATE 5-PHOSPHATASE; 1.
DR PANTHER; PTHR46625:SF1; PHOSPHATIDYLINOSITOL POLYPHOSPHATE 5-PHOSPHATASE TYPE IV; 1.
DR SMART; SM00128; IPPc; 1.
DR SUPFAM; SSF56219; DNase I-like; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000265080};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 361..379
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 408..427
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 299..601
FT /note="Inositol polyphosphate-related phosphatase"
FT /evidence="ECO:0000259|SMART:SM00128"
FT REGION 1..196
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 25..39
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 98..115
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 128..155
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 158..184
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 646 AA; 72443 MW; CC7166FF45E0B84E CRC64;
MTENGEDCPL HQSDEAPGKG NSVGNDSKPL KTSLVGVKSA SEHNDELKLA AAAAAARNAG
GEISPYQPRP PLLPRLSSRS GSIEETVRTR RLKNSQESLS DPTETGSSTD SLREDQTVPP
PDRFVFSGDT TVKNSQDSSI RPRSAATTGS PVFRDRGSSL SEYERRPRSQ QSDPTDHRER
STKLRLSPVQ PTGPLPALER SFASATLRAA NRIDRDCLDY AVLAREKLGE RLHRNLSDSR
LLENMGSDSA SVNSMRSTYS VLSPIRPQDV RNRSFLEGSV LGSGALLGAE ELDRYFPDRR
VGVYIATWNM QGEKGLPTNL DDLLLPTDSE FAQDFYIIGV QEGCPDRREW ETRLQETLGP
YYVMLYAASH GVLYLTVFVR RDLIWFCSEV EHATVTTRII SQIKTKGAVG IAFTFFGTSF
LFITSHFTSG DAKVYERILD YNKIVEALAL PKGLPDTNPY RSTPSDVTTR FDQVFWFGDF
NFRLSKDRAD VEMMMNRTGD GDKSLLLEHD QLSKEMKDGS IFKGFQEAPI TFYPTYKFDI
GCDIYDTTSK QRTPSYTDRI LFRNRQTDDI KVVKYTSCSN IKTSDHRPVI GVFQVKLRPG
RDNIPLGAGQ FDRGLYLEGI RRRITRELKR REAMKNQSSS TICTIS
//
