ID A0A3P8SNL0_AMPPE Unreviewed; 581 AA.
AC A0A3P8SNL0;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE RecName: Full=phosphoenolpyruvate carboxykinase (GTP) {ECO:0000256|ARBA:ARBA00012306};
DE EC=4.1.1.32 {ECO:0000256|ARBA:ARBA00012306};
OS Amphiprion percula (Orange clownfish) (Lutjanus percula).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Amphiprion.
OX NCBI_TaxID=161767 {ECO:0000313|Ensembl:ENSAPEP00000013720.1, ECO:0000313|Proteomes:UP000265080};
RN [1] {ECO:0000313|Ensembl:ENSAPEP00000013720.1, ECO:0000313|Proteomes:UP000265080}
RP NUCLEOTIDE SEQUENCE.
RA Lehmann R.;
RT "Finding Nemo's genes: A chromosome-scale reference assembly of the genome
RT of the orange clownfish Amphiprion percula.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPEP00000013720.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
CC -!- PATHWAY: Carbohydrate biosynthesis; gluconeogenesis.
CC {ECO:0000256|ARBA:ARBA00004742}.
CC -!- SIMILARITY: Belongs to the phosphoenolpyruvate carboxykinase [GTP]
CC family. {ECO:0000256|ARBA:ARBA00005796}.
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DR AlphaFoldDB; A0A3P8SNL0; -.
DR Ensembl; ENSAPET00000014083.1; ENSAPEP00000013720.1; ENSAPEG00000009747.1.
DR GeneTree; ENSGT00390000001912; -.
DR UniPathway; UPA00138; -.
DR Proteomes; UP000265080; Chromosome 22.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004613; F:phosphoenolpyruvate carboxykinase (GTP) activity; IEA:UniProtKB-EC.
DR GO; GO:0006094; P:gluconeogenesis; IEA:UniProtKB-UniPathway.
DR CDD; cd00819; PEPCK_GTP; 1.
DR Gene3D; 3.90.228.20; -; 1.
DR Gene3D; 3.40.449.10; Phosphoenolpyruvate Carboxykinase, domain 1; 1.
DR Gene3D; 2.170.8.10; Phosphoenolpyruvate Carboxykinase, domain 2; 1.
DR HAMAP; MF_00452; PEPCK_GTP; 1.
DR InterPro; IPR018091; PEP_carboxykin_GTP_CS.
DR InterPro; IPR013035; PEP_carboxykinase_C.
DR InterPro; IPR008209; PEP_carboxykinase_GTP.
DR InterPro; IPR035077; PEP_carboxykinase_GTP_C.
DR InterPro; IPR035078; PEP_carboxykinase_GTP_N.
DR InterPro; IPR008210; PEP_carboxykinase_N.
DR PANTHER; PTHR11561; PHOSPHOENOLPYRUVATE CARBOXYKINASE; 1.
DR PANTHER; PTHR11561:SF11; PHOSPHOENOLPYRUVATE CARBOXYKINASE [GTP], MITOCHONDRIAL; 1.
DR Pfam; PF00821; PEPCK_GTP; 2.
DR Pfam; PF17297; PEPCK_N; 1.
DR PIRSF; PIRSF001348; PEP_carboxykinase_GTP; 2.
DR SUPFAM; SSF68923; PEP carboxykinase N-terminal domain; 1.
DR SUPFAM; SSF53795; PEP carboxykinase-like; 1.
DR PROSITE; PS00505; PEPCK_GTP; 1.
PE 3: Inferred from homology;
KW Decarboxylase {ECO:0000256|ARBA:ARBA00022793};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Lyase {ECO:0000256|ARBA:ARBA00023239};
KW Manganese {ECO:0000256|ARBA:ARBA00023211};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000265080}.
FT DOMAIN 3..232
FT /note="Phosphoenolpyruvate carboxykinase GTP-utilising N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF17297"
FT DOMAIN 236..416
FT /note="Phosphoenolpyruvate carboxykinase C-terminal P-loop"
FT /evidence="ECO:0000259|Pfam:PF00821"
FT DOMAIN 424..578
FT /note="Phosphoenolpyruvate carboxykinase C-terminal P-loop"
FT /evidence="ECO:0000259|Pfam:PF00821"
SQ SEQUENCE 581 AA; 64177 MW; 02FC33876B5BDBE0 CRC64;
VAEYVKGAVE ECKPSGVRVV TGTPQETANI LAGLQKEGMV KKLPKYENCW LARTDPKDVA
RVESKTVIVT KNQRDTIPIP AGGVKSQLGN WMSESDWQKA RQERFPGSMA GRTMYVIPFS
MGPVGSSLTK YGVQVTDSPY VVASMGIMTR MGTPVLNKLA EGVEFVRCQH TVGRPLPLKA
PLVNSWPCNP DKVLISHLPD TRQILSFGSG YGGNSLLGKK CFALRIASRI AKDEGWLAEH
MLILGITNPQ GVKRYVAAAF PSACGKTNLA MMKPSLPGWK VECVGDDIAW MKFDSQGKLR
AINPENGFFG VAPGTSDKTN PYAMATIAKN TVFTNVGETS DGGVWWEGLN SPPAGVTLTD
WHGKTWKQGS STTCAHPNSR FCAPAAQCPI IDPQWESEEG VPIDAIIFGG RRPEGWCCFH
TRHMESKVIM HDPFAMRPFF GYNFGDYLAH WLSMQSRKAP THLPKIFHVN WFRKDPASGA
FLWPGFGENA RVLEWIFKRC SREREDEAAE KSIIGWLPVD GAIDTKGLSA EVDMGALFDV
PKPFWQKETK ELRAYFTQQV GADLPPQVEA ELKALEDRVH K
//
