ID   A0A3P8SQ14_AMPPE        Unreviewed;       676 AA.
AC   A0A3P8SQ14;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   SubName: Full=Chloride channel K {ECO:0000313|Ensembl:ENSAPEP00000014285.1};
OS   Amphiprion percula (Orange clownfish) (Lutjanus percula).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Pomacentridae; Amphiprion.
OX   NCBI_TaxID=161767 {ECO:0000313|Ensembl:ENSAPEP00000014285.1, ECO:0000313|Proteomes:UP000265080};
RN   [1] {ECO:0000313|Ensembl:ENSAPEP00000014285.1, ECO:0000313|Proteomes:UP000265080}
RP   NUCLEOTIDE SEQUENCE.
RA   Lehmann R.;
RT   "Finding Nemo's genes: A chromosome-scale reference assembly of the genome
RT   of the orange clownfish Amphiprion percula.";
RL   Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSAPEP00000014285.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR   AlphaFoldDB; A0A3P8SQ14; -.
DR   STRING; 161767.ENSAPEP00000014285; -.
DR   Ensembl; ENSAPET00000014663.1; ENSAPEP00000014285.1; ENSAPEG00000010139.1.
DR   GeneTree; ENSGT00940000164106; -.
DR   OMA; VCGMEWY; -.
DR   Proteomes; UP000265080; Chromosome 8.
DR   GO; GO:0034702; C:monoatomic ion channel complex; IEA:UniProtKB-KW.
DR   GO; GO:0005247; F:voltage-gated chloride channel activity; IEA:InterPro.
DR   Gene3D; 3.10.580.10; CBS-domain; 1.
DR   Gene3D; 1.10.3080.10; Clc chloride channel; 1.
DR   InterPro; IPR046342; CBS_dom_sf.
DR   InterPro; IPR014743; Cl-channel_core.
DR   InterPro; IPR001807; Cl-channel_volt-gated.
DR   PANTHER; PTHR45720; CHLORIDE CHANNEL PROTEIN 2; 1.
DR   PANTHER; PTHR45720:SF3; CHLORIDE CHANNEL PROTEIN CLC-KB; 1.
DR   Pfam; PF00654; Voltage_CLC; 1.
DR   PRINTS; PR00762; CLCHANNEL.
DR   SUPFAM; SSF54631; CBS-domain pair; 1.
DR   SUPFAM; SSF81340; Clc chloride channel; 1.
PE   4: Predicted;
KW   CBS domain {ECO:0000256|ARBA:ARBA00023122};
KW   Ion channel {ECO:0000256|ARBA:ARBA00022882};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265080};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW   Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882}.
FT   TRANSMEM        61..80
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        100..121
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        155..174
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        212..234
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        246..267
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        287..312
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        336..354
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        399..422
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          1..23
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   676 AA;  73651 MW;  6ED61D0AB68DB7F5 CRC64;
     MTLETDGENN SQEQDNRPET SHNKNCLLSH PWKPCRRPHA IVKEWLLRLR LCLGTVCGME
     WYGYAILGIS TAILSFLMDL SVTKLLTAHQ WLYMKLEGNI LLQFFCWTLY PACLCCFASS
     FSHNICPFST GSGIPEVRTM MAGIEMPHYL SLTNMFTKFL GLICTLAAGS TAFLGKVGPF
     VHLSTMLGAY LSKLCTLIQA NKMEKADDEM LVVAAAVGVA SCFGAPISGV LFSVEVMSSH
     FALRHYCPCF FSAACGALTF RLLSVWSGDG ETLQALFKTN FPTAVPFYPF EVLLFAFLGL
     LCGAVSCCYL FCHRLILRFT KTNTVFIKML TTEKGLYSGM VVFFLASLTF PYSAGQYMAS
     KYTMKQLLTS LLDNGQWSSQ FRNASLQVEP SLGWSSSGIP VYLSLAFFLL MKMWMLVLAC
     TLPLPAGYFM PVFVYGAAIG RLLGEGVAYV SSTGGTSGQQ WASINPGGYA LAGAAAFSGA
     VTHTLSPVLL AVELTGQFSH AVPILLATLL ANALARSGHH PSFYDAISIS KRLPHLPSLR
     KANPRIPSTP LGQVLGVKSV QLQKAAGPVE VLHAVNSSTD TQIPVVESHE SQVLLGFVLR
     PELLMFLRHC KAEGLEKHLD EVCCIHPTSV LLSPHNTVQE AVSILTLVGA QTLFVADRGR
     LLGLITWPEV VSVCMS
//