ID A0A3P8SQE5_AMPPE Unreviewed; 1573 AA.
AC A0A3P8SQE5;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE RecName: Full=Complement component c3a, duplicate 5 {ECO:0008006|Google:ProtNLM};
OS Amphiprion percula (Orange clownfish) (Lutjanus percula).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Amphiprion.
OX NCBI_TaxID=161767 {ECO:0000313|Ensembl:ENSAPEP00000014287.1, ECO:0000313|Proteomes:UP000265080};
RN [1] {ECO:0000313|Ensembl:ENSAPEP00000014287.1, ECO:0000313|Proteomes:UP000265080}
RP NUCLEOTIDE SEQUENCE.
RA Lehmann R.;
RT "Finding Nemo's genes: A chromosome-scale reference assembly of the genome
RT of the orange clownfish Amphiprion percula.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPEP00000014287.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
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DR Ensembl; ENSAPET00000014665.1; ENSAPEP00000014287.1; ENSAPEG00000008225.1.
DR GeneTree; ENSGT00940000154063; -.
DR Proteomes; UP000265080; Chromosome 3.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0004866; F:endopeptidase inhibitor activity; IEA:InterPro.
DR CDD; cd00017; ANATO; 1.
DR CDD; cd02896; complement_C3_C4_C5; 1.
DR CDD; cd03583; NTR_complement_C3; 1.
DR Gene3D; 1.50.10.20; -; 1.
DR Gene3D; 2.20.130.20; -; 1.
DR Gene3D; 2.40.50.120; -; 1.
DR Gene3D; 2.60.120.1540; -; 1.
DR Gene3D; 2.60.40.1930; -; 3.
DR Gene3D; 2.60.40.1940; -; 1.
DR Gene3D; 6.20.50.160; -; 1.
DR Gene3D; 2.60.40.690; Alpha-macroglobulin, receptor-binding domain; 1.
DR Gene3D; 1.20.91.20; Anaphylotoxins (complement system); 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR009048; A-macroglobulin_rcpt-bd.
DR InterPro; IPR036595; A-macroglobulin_rcpt-bd_sf.
DR InterPro; IPR011625; A2M_N_BRD.
DR InterPro; IPR047565; Alpha-macroglob_thiol-ester_cl.
DR InterPro; IPR011626; Alpha-macroglobulin_TED.
DR InterPro; IPR000020; Anaphylatoxin/fibulin.
DR InterPro; IPR018081; Anaphylatoxin_comp_syst.
DR InterPro; IPR041425; C3/4/5_MG1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR001599; Macroglobln_a2.
DR InterPro; IPR019742; MacrogloblnA2_CS.
DR InterPro; IPR041555; MG3.
DR InterPro; IPR040839; MG4.
DR InterPro; IPR001134; Netrin_domain.
DR InterPro; IPR018933; Netrin_module_non-TIMP.
DR InterPro; IPR035815; NTR_complement_C3.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR InterPro; IPR008993; TIMP-like_OB-fold.
DR PANTHER; PTHR11412:SF81; COMPLEMENT C3; 1.
DR PANTHER; PTHR11412; MACROGLOBULIN / COMPLEMENT; 1.
DR Pfam; PF00207; A2M; 1.
DR Pfam; PF07703; A2M_BRD; 1.
DR Pfam; PF07677; A2M_recep; 1.
DR Pfam; PF01821; ANATO; 1.
DR Pfam; PF17790; MG1; 1.
DR Pfam; PF17791; MG3; 1.
DR Pfam; PF17789; MG4; 1.
DR Pfam; PF01759; NTR; 1.
DR Pfam; PF07678; TED_complement; 1.
DR SMART; SM01360; A2M; 1.
DR SMART; SM01359; A2M_N_2; 1.
DR SMART; SM01361; A2M_recep; 1.
DR SMART; SM00104; ANATO; 1.
DR SMART; SM00643; C345C; 1.
DR SMART; SM01419; Thiol-ester_cl; 1.
DR SUPFAM; SSF49410; Alpha-macroglobulin receptor domain; 1.
DR SUPFAM; SSF47686; Anaphylotoxins (complement system); 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
DR SUPFAM; SSF50242; TIMP-like; 1.
DR PROSITE; PS00477; ALPHA_2_MACROGLOBULIN; 1.
DR PROSITE; PS01177; ANAPHYLATOXIN_1; 1.
DR PROSITE; PS01178; ANAPHYLATOXIN_2; 1.
DR PROSITE; PS50189; NTR; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Reference proteome {ECO:0000313|Proteomes:UP000265080};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Thioester bond {ECO:0000256|ARBA:ARBA00022966}.
FT DOMAIN 632..667
FT /note="Anaphylatoxin-like"
FT /evidence="ECO:0000259|PROSITE:PS01178"
FT DOMAIN 1426..1570
FT /note="NTR"
FT /evidence="ECO:0000259|PROSITE:PS50189"
SQ SEQUENCE 1573 AA; 178162 MW; D09DBCE83F1D3B80 CRC64;
IFLSSLFREV MSAPNLLRVG AVENIFIEIQ DCTLEDPVNV DIIVKNHPTR KNVLDSTSVT
LNKTNKFQEI GRIMIPAEHF SKDPKVKQYV YLQAKFPDRE LEKVVLVSFQ SGYIFIQTDK
TIYTPGTPVL YRLFAVRPGM EPVERENQMD TSVTIEITVF TGLWKVVAKF ESNLQQSFVA
EFEVKEYVLP SFEVKLTSEI PFFYVDSEEL DINIKARYLF GEEVDGTAYV VFGIMNKGQK
KSLSSSLQRV QIVDGNGVAK LKKQHITDTF QNILDLEGSS IYVSVSVLTE SGSEMVEAEL
RGIQIVKSPY TIHFKKTRQY FRPGISFDVA IEVVNPDGSP AKGVTVVVEP GNVRGVTESN
GMARLPVNTE EIFAPLLIKA RTDVRGITLE RQASANMTAL PFTSRSNNFI HIGVDTAEVK
LGDNLNIRLN LNRQESQEND ITYLVLSRGQ LVKHGRHRNK RQTLISFPLI ITKEMLPSFR
LVAYYHPNSG EVVSDSIWID VEDSCMGSLK LEQPKRENSY EPRNTFGLKI TGDPESRVGL
VAVDKGVYVL NNKHRLTQKK IWDVVEKYDT GCTPGGGKDS INVFFDAGLM FETNTASGTS
SSSNSRRKRA ITIMEVRTSL ASQYEDKEER ECCLDGMSDV PVSYSCERRS EYILDGQGCV
KAFLNCCREM ERQQNERRED ALQLARTEED DSYMDSDEIV TRTKFPERWQ CTETSYSITT
WEFTGISLSR THGICVADPL EITVRKKFFI DLRLPYSAVR GEQLEIKAVL HNYTPERIRV
RVDLKEEANL CSAAYKRGKF RQEVDVGPET TRVLPFIIIP MKNGRFPIEV KAAVRETFLS
DGIQKMLLVV VRERLFSGVR AWSAILEMIE IQPEERINSR IPAVDLVPDT PMSTIISLTG
REQMSGLFDH AISGNSMGNL IRQPYGCGEQ NMITMTLPVI AAVYLDKTNQ WETVGFNKRN
DAIRHITTGY TSQLKFRKGD GSFTVHPDYQ SSTWLTAYVT KVFSMAYNLV TVQNNVICDA
IKYLILTSKK PDGMFTELGY VYHQEMIGDV VGLDSDVSMT AFCLIALQES RTICSTTSLP
SSIDQAVSYL EKRLSSITNP YAAAMASYAL ANENKLNKEI LYKSASSDRS HWPVRNDHVL
TLEATAYALL ALVKTGAFEE AKPIVRWLSQ QQKQGGGYGS TQATIMVYQA VAEYWTTAKE
PEYDLDVDIL LPGKSLIDKY KFNKENHHST RTSKFGGINK DIKVTATGTG EAMFRMVSLY
YALPKEKKSD CEMFDLNVQV HPVKLGEDER IYKLQIEVMF KDKQRSTTMS ILDVGFPTGF
TFNKDDLDRL SKGRARIISK YEMDKVLSDR GSLIIYLDKI SNVRSEEISF RIHQDMKVGI
LQPAAVSVYE YNNKKHCVKF YHPERRQGEL LKLCTAKECT CAEENCSMQK KEHVSNDERS
AKACEITDAG KIDFVYKAKV ESFKDALSTD IYTVRVLEVV KEGTTDVGPQ NQLRTFLSYQ
HCREALDLKQ NKTYLIMGTS KDIHTASTYV LGERTWIEYW PTVAECQTDE YRATCLGIEE
LVLQYTIFGC EQK
//
