ID   A0A3P8SRJ6_AMPPE        Unreviewed;       877 AA.
AC   A0A3P8SRJ6;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 20.
DE   RecName: Full=Oxysterol-binding protein {ECO:0000256|RuleBase:RU003845};
GN   Name=OSBPL3 {ECO:0000313|Ensembl:ENSAPEP00000014511.1};
OS   Amphiprion percula (Orange clownfish) (Lutjanus percula).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Pomacentridae; Amphiprion.
OX   NCBI_TaxID=161767 {ECO:0000313|Ensembl:ENSAPEP00000014511.1, ECO:0000313|Proteomes:UP000265080};
RN   [1] {ECO:0000313|Ensembl:ENSAPEP00000014511.1, ECO:0000313|Proteomes:UP000265080}
RP   NUCLEOTIDE SEQUENCE.
RA   Lehmann R.;
RT   "Finding Nemo's genes: A chromosome-scale reference assembly of the genome
RT   of the orange clownfish Amphiprion percula.";
RL   Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSAPEP00000014511.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the OSBP family.
CC       {ECO:0000256|RuleBase:RU003844}.
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DR   AlphaFoldDB; A0A3P8SRJ6; -.
DR   Ensembl; ENSAPET00000014894.1; ENSAPEP00000014511.1; ENSAPEG00000010289.1.
DR   GeneTree; ENSGT00940000155957; -.
DR   Proteomes; UP000265080; Chromosome 7.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR   GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR   CDD; cd13287; PH_ORP3_ORP6_ORP7; 1.
DR   Gene3D; 2.40.160.120; -; 1.
DR   Gene3D; 3.30.70.3490; -; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR037239; OSBP_sf.
DR   InterPro; IPR000648; Oxysterol-bd.
DR   InterPro; IPR018494; Oxysterol-bd_CS.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR041680; PH_8.
DR   InterPro; IPR001849; PH_domain.
DR   PANTHER; PTHR10972; OXYSTEROL-BINDING PROTEIN-RELATED; 1.
DR   PANTHER; PTHR10972:SF15; OXYSTEROL-BINDING PROTEIN-RELATED PROTEIN 3; 1.
DR   Pfam; PF01237; Oxysterol_BP; 1.
DR   Pfam; PF15409; PH_8; 1.
DR   SMART; SM00233; PH; 1.
DR   SUPFAM; SSF144000; Oxysterol-binding protein-like; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS01013; OSBP; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Lipid transport {ECO:0000256|ARBA:ARBA00023055,
KW   ECO:0000256|RuleBase:RU003845};
KW   Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265080};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003845}.
FT   DOMAIN          46..141
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   COILED          805..835
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   877 AA;  99876 MW;  18F117443C3AB441 CRC64;
     MTADRGFGLD RSNLSQEMII VRSDIRQDSW EIVEGLRGGF SSVLEPQKQE GYMLKRRKWP
     MKGWHKRYFF LDKGILKYGK CSPDIEKGKL HGCIDVGLSV MAIKKKAKCI DLDAEENIYH
     LKIKSQELFD EWVSKLRHHR LYRQNEIAMY PNEKSFYYPH YPSPNSPNMS DGASIRKCMP
     VRRQSTVPSA GAFPLSSNSQ AKVAAWLQSS DDMDKCSKDL SVCEAYLLEL NHLLQSMEVL
     HRTYSAPSIQ ALQASTFDSP KKEKRLPRKW RSKNYNKDVK TTLQVPSCIS SGSIRLHASN
     PNLSTAALGN DKVDPESLDS PFDVAKLQED FCRVAANLHT IMKSALTSLT SERERLKQCL
     DHETCPPTSP QVVSLKNALA SAVAQNSELR ERLCKIHAES HIVEPTLINL TAPVQKQDSV
     DESRPLVHQV SNESRASIAE SLSEFFDAQE VLLSASSSEN EVSEDDSYIS DISDNISMDN
     FSNESERPNS GSVEEGTVIC QRRSCLPMPS PNNSTISLWN ILRNNIGKDL SKVAMPVQLN
     EPLNTLQRLC EELEYSELLD RAANTQDPFE RMIYMATFVV SGYASSYYRT GGKPFNPVLG
     ETYECDRPDK GFRFVAEQVS HHPPISACHA ESKNFVFWQD VRCKNKFWGK SMEIVPVGTT
     HVTLPGCGDH YEWNKVTSCI HNILSGQRWI EHYGEISIRN SNSDVCQCKI TFVKAKYWNS
     SVNEIEGAIT DNKGKVVHKL FGKWHEAVFC GDPPSAKCIW RANAMPVDHE QYYGFTKFAI
     ELNELEPSLK LLLPPTDTRL RVDQRLLEEG NMEAAEEQKQ RIEQLQRDRR RVLEENSVTH
     QPKFFRKSKD DTWVNNSTYW EVRKDPGFTH IDFPTLW
//