ID   A0A3P8SS38_AMPPE        Unreviewed;       805 AA.
AC   A0A3P8SS38;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   SubName: Full=RNA exonuclease 5 {ECO:0000313|Ensembl:ENSAPEP00000014917.1};
GN   Name=REXO5 {ECO:0000313|Ensembl:ENSAPEP00000014917.1};
OS   Amphiprion percula (Orange clownfish) (Lutjanus percula).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Pomacentridae; Amphiprion.
OX   NCBI_TaxID=161767 {ECO:0000313|Ensembl:ENSAPEP00000014917.1, ECO:0000313|Proteomes:UP000265080};
RN   [1] {ECO:0000313|Ensembl:ENSAPEP00000014917.1, ECO:0000313|Proteomes:UP000265080}
RP   NUCLEOTIDE SEQUENCE.
RA   Lehmann R.;
RT   "Finding Nemo's genes: A chromosome-scale reference assembly of the genome
RT   of the orange clownfish Amphiprion percula.";
RL   Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSAPEP00000014917.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A3P8SS38; -.
DR   STRING; 161767.ENSAPEP00000014917; -.
DR   Ensembl; ENSAPET00000015307.1; ENSAPEP00000014917.1; ENSAPEG00000010627.1.
DR   GeneTree; ENSGT00940000161162; -.
DR   Proteomes; UP000265080; Chromosome 3.
DR   GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR   CDD; cd06145; REX1_like; 1.
DR   Gene3D; 3.30.70.330; -; 2.
DR   Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR   InterPro; IPR013520; Exonuclease_RNaseT/DNA_pol3.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR034922; REX1-like_exo.
DR   InterPro; IPR047021; REXO1/3/4-like.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   InterPro; IPR000504; RRM_dom.
DR   PANTHER; PTHR12801:SF115; RNA EXONUCLEASE 5; 1.
DR   PANTHER; PTHR12801; RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED; 1.
DR   Pfam; PF00929; RNase_T; 1.
DR   Pfam; PF00076; RRM_1; 2.
DR   SMART; SM00479; EXOIII; 1.
DR   SMART; SM00360; RRM; 2.
DR   SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR   SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
DR   PROSITE; PS50102; RRM; 1.
PE   4: Predicted;
KW   Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022839};
KW   Nuclease {ECO:0000256|ARBA:ARBA00022839};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265080};
KW   RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00176}.
FT   DOMAIN          500..574
FT                   /note="RRM"
FT                   /evidence="ECO:0000259|PROSITE:PS50102"
FT   REGION          1..50
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..19
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        21..43
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   805 AA;  89640 MW;  6817AD1E4E921971 CRC64;
     MESSSSLSSS PSLCNTKKRK NTAVGAHEKA KTLKTEQEGD EALQSGRLSR SPRVSVPLDC
     LQQPITLNKL TELLHYAALG RTGGIKQPSW CRLRHQRKVE GLNVVIVEGL TQSHFYKHYL
     SLRQLRTKYT TRVTFTPSCN NVASGIFSSE LPKMDCVYFS KPDNDLHSAL KGHPVIAKFG
     TQRRGLTAYV LTQEEMIKKH YPVKGMPGFE EFVSTDSVDC VTDSSPLYGL DCEMCLTEKG
     HELTRVSVVD SDGNCVLDDL VKPKNRILNY LTKFSGITAA MLQPITTTLR DVQEKLRMLL
     PGDAVLVGHS INNDLIALKL IHQHVIDTSL LYRREFGQRF KLKVLAETVL KRQIQTEEKK
     GHNPSEDAAA ALELAQYFIK TGPRQVVERH LEELWGYTIE EEESSDCKSA PTPSLRFADI
     LQLLGRSVAF LGKRSDVALN LSNQQWYSSD KEVLESFKRQ TKHPFLSVVQ FSSFSNHLKR
     RVLHQEQLHR SLCANLRDMC VVFAGPFPAG FSERQVRRLF HCCGPVGRIK MLHTSVRVHA
     EVEFELLEGA TLALKTLNGL NVQGQPMKVQ RPMNESMLDL DLTLDALTGD TLNTSHLYAI
     KLNPSVAECI KSSAKVNGHT LDSKCSGVSP VNGLPAAKTN LLQLTDTRST LSEETVTETF
     GHFGTVERVI LPAKPGKHTR HACIKFESSE GKHAALSSSK YLRQENYLIC QSLTPPHLPS
     WVAMATPVTT IRGDGEAAED ENTANMYHSS QDLEMDHMMK KLDSRLGKLF RSLPDSTLSV
     VVLLGHTSVN GHFPGLCLME VKQGS
//