ID A0A3P8SSK2_AMPPE Unreviewed; 669 AA.
AC A0A3P8SSK2;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Tripartite motif containing 67 {ECO:0000313|Ensembl:ENSAPEP00000015309.1};
GN Name=TRIM67 {ECO:0000313|Ensembl:ENSAPEP00000015309.1};
OS Amphiprion percula (Orange clownfish) (Lutjanus percula).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Amphiprion.
OX NCBI_TaxID=161767 {ECO:0000313|Ensembl:ENSAPEP00000015309.1, ECO:0000313|Proteomes:UP000265080};
RN [1] {ECO:0000313|Ensembl:ENSAPEP00000015309.1, ECO:0000313|Proteomes:UP000265080}
RP NUCLEOTIDE SEQUENCE.
RA Lehmann R.;
RT "Finding Nemo's genes: A chromosome-scale reference assembly of the genome
RT of the orange clownfish Amphiprion percula.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPEP00000015309.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
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DR AlphaFoldDB; A0A3P8SSK2; -.
DR STRING; 161767.ENSAPEP00000015309; -.
DR Ensembl; ENSAPET00000015708.1; ENSAPEP00000015309.1; ENSAPEG00000010814.1.
DR GeneTree; ENSGT00940000154071; -.
DR Proteomes; UP000265080; Chromosome 11.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd00063; FN3; 1.
DR CDD; cd12889; SPRY_PRY_TRIM67_9; 1.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 2.60.120.920; -; 1.
DR Gene3D; 4.10.830.40; -; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR003649; Bbox_C.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR017903; COS_domain.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003877; SPRY_dom.
DR InterPro; IPR000315; Znf_B-box.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR24099; E3 UBIQUITIN-PROTEIN LIGASE TRIM36-RELATED; 1.
DR PANTHER; PTHR24099:SF21; TRIPARTITE MOTIF-CONTAINING PROTEIN 67; 1.
DR Pfam; PF00041; fn3; 1.
DR Pfam; PF00622; SPRY; 1.
DR Pfam; PF00643; zf-B_box; 1.
DR SMART; SM00502; BBC; 1.
DR SMART; SM00336; BBOX; 2.
DR SMART; SM00060; FN3; 1.
DR SMART; SM00184; RING; 1.
DR SMART; SM00449; SPRY; 1.
DR SUPFAM; SSF57845; B-box zinc-binding domain; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50188; B302_SPRY; 1.
DR PROSITE; PS51262; COS; 1.
DR PROSITE; PS50853; FN3; 1.
DR PROSITE; PS50119; ZF_BBOX; 2.
DR PROSITE; PS00518; ZF_RING_1; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000265080};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00024}.
FT DOMAIN 141..190
FT /note="B box-type"
FT /evidence="ECO:0000259|PROSITE:PS50119"
FT DOMAIN 200..242
FT /note="B box-type"
FT /evidence="ECO:0000259|PROSITE:PS50119"
FT DOMAIN 350..408
FT /note="COS"
FT /evidence="ECO:0000259|PROSITE:PS51262"
FT DOMAIN 414..505
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 487..669
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
SQ SEQUENCE 669 AA; 74702 MW; AB975A4D3332CE82 CRC64;
MEKKTMEEEL KCPVCGFLFK DPILLPCSHN VCLACARNIT VQTPDGETPV QSRASGSSDY
DYLDMDKMSL YSETDSGYGS YTPCQLKSPN GVRVFPPALP HRHCSLTCPL CHRSVSLDER
GLRGFPRNRL LEAIVSRYQQ NRAVKCQLCD RNPVDASVMC EQCDVYYCNA CQQRCHPSRG
PLAKHRLVPP GGQQPPATAR KPATCVDHEA ENFSMYCCSC KAPVCMKCLE EGKHAKHDVK
PLAVMWKQHK CQISQALNGV SEKAKDAKEF LVQLKNMLQQ IQENGVEFEA CLVAQCDSLI
EALTRQKAKL LTKVTKEKEY KLKVVRDQIT HCTMKLRQTT GMMEYCLEVL KENDPSGFLQ
ISDPLIKRVT SSQDQWVKGA LEPKVGPDFD LTLNTDSLLQ TILQLDFCQG KAAPLLQLEK
CCTRNNSATL AWRVTVPTGS PIEGYILELD DGNGGQYREV YVGKETVCTV DGLHFNSSYN
ARVKAYNGIG VGPYSKTVVL KTSDVAWFTF DPTSAHRDIV LSNENQTVSC NSYDDRVVLG
TAAFSKGIHY WEITIDRYDN HPDPAFGVAR INTMKDMMLG KDDKAWAMYV DNNRSWFMHN
NSHTNRAEGG ITKGSSVGVL LDLIKHTLTF YINKEQHGPT AFENLDGVFV PAVSLNRNVQ
VGVCIKDGI
//
