ID   A0A3P8SUK9_AMPPE        Unreviewed;      1512 AA.
AC   A0A3P8SUK9;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   24-JAN-2024, entry version 19.
DE   SubName: Full=RPTOR independent companion of MTOR, complex 2 a {ECO:0000313|Ensembl:ENSAPEP00000015923.1};
GN   Name=RICTOR {ECO:0000313|Ensembl:ENSAPEP00000015923.1};
OS   Amphiprion percula (Orange clownfish) (Lutjanus percula).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Pomacentridae; Amphiprion.
OX   NCBI_TaxID=161767 {ECO:0000313|Ensembl:ENSAPEP00000015923.1, ECO:0000313|Proteomes:UP000265080};
RN   [1] {ECO:0000313|Ensembl:ENSAPEP00000015923.1, ECO:0000313|Proteomes:UP000265080}
RP   NUCLEOTIDE SEQUENCE.
RA   Lehmann R.;
RT   "Finding Nemo's genes: A chromosome-scale reference assembly of the genome
RT   of the orange clownfish Amphiprion percula.";
RL   Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSAPEP00000015923.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the RICTOR family.
CC       {ECO:0000256|ARBA:ARBA00008878}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   Ensembl; ENSAPET00000016341.1; ENSAPEP00000015923.1; ENSAPEG00000011164.1.
DR   GeneTree; ENSGT00390000002096; -.
DR   OMA; CEQTIHH; -.
DR   Proteomes; UP000265080; Chromosome 5.
DR   GO; GO:0031932; C:TORC2 complex; IEA:InterPro.
DR   GO; GO:0031929; P:TOR signaling; IEA:InterPro.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR028268; Pianissimo_fam.
DR   InterPro; IPR028267; Pianissimo_N.
DR   InterPro; IPR029453; Rictor_IV.
DR   InterPro; IPR029451; RICTOR_M.
DR   InterPro; IPR029259; RICTOR_phospho.
DR   InterPro; IPR029452; RICTOR_V.
DR   PANTHER; PTHR13298; CYTOSOLIC REGULATOR PIANISSIMO; 1.
DR   PANTHER; PTHR13298:SF11; RAPAMYCIN-INSENSITIVE COMPANION OF MTOR; 1.
DR   Pfam; PF14663; RasGEF_N_2; 1.
DR   Pfam; PF14666; RICTOR_M; 1.
DR   Pfam; PF14664; RICTOR_N; 1.
DR   Pfam; PF14665; RICTOR_phospho; 1.
DR   Pfam; PF14668; RICTOR_V; 1.
DR   SMART; SM01303; RasGEF_N_2; 1.
DR   SMART; SM01307; RICTOR_M; 1.
DR   SMART; SM01308; RICTOR_N; 1.
DR   SMART; SM01309; RICTOR_phospho; 1.
DR   SMART; SM01310; RICTOR_V; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000265080}.
FT   DOMAIN          1..287
FT                   /note="Rapamycin-insensitive companion of mTOR N-terminal"
FT                   /evidence="ECO:0000259|SMART:SM01308"
FT   DOMAIN          371..590
FT                   /note="Rapamycin-insensitive companion of mTOR middle"
FT                   /evidence="ECO:0000259|SMART:SM01307"
FT   DOMAIN          768..840
FT                   /note="Rapamycin-insensitive companion of mTOR"
FT                   /evidence="ECO:0000259|SMART:SM01310"
FT   REGION          864..890
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          930..973
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          996..1056
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1076..1104
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        996..1042
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1512 AA;  168478 MW;  798040A4C33CD1E4 CRC64;
     IITVNAMLFP TSIANSLIAV GTDGLQERDR MVRAAIAIVC ELALKNPEVV AKRGGLSTIL
     KSVIDCQLSR INEALITTVL HLLNHPRTRQ YVRVDVELEQ ILAPFTDFHY RHNADTAEGQ
     LKEDREARFL SSRMAIVAAF RSWSGIINLC KAGNSGIQSL IGLLCIPNME VRKGLLEVLY
     EIFRLPVPIV TQDFTEAFLS VDPARFQDTW RLSDGFVAAE AKVILPHRAR SRPDLMDNYL
     AFVLSAFITS GLLEGLVEVV TSSDDQLAVR ATILLGELLH MANTILPHSH SHHLHCLPTL
     INMAASFDIP QEKRLRASAA VNNLKRFHEK KKKGLKPHSL YLDHIIRKSV SSHNRRESHS
     RVHRDIYVIK DTEEALMMNL RDSHILNHKQ NLEWNWLLIA TILKWPNVNL RNNKDEQMHK
     FVRRLLYFYK PSSKLYAGLA LDHLKARQLT VVGCQFVEFL MDSDEDGQGY LEDLVRDMVA
     WLSSSSGLKP ERCLQSNGLL MTLSQHYFLF LGTLSAHPQG VKLLEKCGLF QCLLNLCSVK
     NQDAVLKLAV STLDYSRDGL ARVILSKILT AATDTCRLYA TKHLRVLLRA GVEFFSSWGM
     ELLVTQLHDH SKAVSIEALD ILDEACEDKA NLHALIQLKP AVSHLGDKGL LLLLRFLSIP
     KGFSYLNERG YVSKQLDKWQ KEYNLKYVDL IEEQLNEALT TYRKPVDGDN YVRRSNQRLQ
     RPNVYLPVHL YGQLVHDKTG CHLLEAQSVV PDLSYTVRSP MLDTWEGIKQ LKAALWALGN
     IGSSNWGLNL LQEENVIPDI LALAQHCEVL SVRGTCVYVL GVISKTRQGC EVLKQYGWDA
     VRHSRRTLWP VTPDEVDTQL TSELSSVPST LSLNSESTSS RHNSESESQP TTFTDRFKTF
     LIDIFSPFTI LASTRFVRTR FLTSLSLPSK KLRSTSDPKT PTGSRTPTEL KTGSMRRNRT
     VTEPSVYSPN QGDVFTPVFN GRGIPKSPTV SLETSFVGTR GAGDGGSSSS TQFKSRSQSF
     NTDTTTSGIS SMSSSPSRET VGNPDHTEPE PDSSDCVSLN TVVSAKTVKT LSSLTPQAQT
     NHMSTSKPST VTLVPPGSSH TLPRRAQSLK SPSVTTIKSL ADCSFMYTSP RDALGYATLK
     RLQQQRIHPS LSHSEALASP AKDVLFTDTI TMKTGSLDSR LTPRSLSPRI LSRTSPLALP
     RFLKALSFAS LDKEELLSPI NQSTLQRCSS VRSMVSSATF GCNDDYIGLA LPMDINDMFH
     IRDSAYFQQR ISPPSEERKR FLFGDGDGDR PAIPVLKQQF SISELIVCRG DSQNHMVGSE
     ETGLQDHTEE NCLYCVGSTV LGYPTQPQIN STHPRTDYVD FPSWAGQSGH RLEVMPQSKF
     SGVSGCSDAA VSQGSICSTP TPGDIDGPAS RVLLRKEVLR LIINLSSSVG TKGHETGLLT
     IKEKFPYAFD DICLYSEVSH LLAHCMFRLT SRRFIQELFQ DVQFMPMFEE AEAILTKLPN
     PVEEDVDPPP ES
//