ID A0A3P8SVX4_AMPPE Unreviewed; 1008 AA.
AC A0A3P8SVX4;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Phospholipase {ECO:0000256|PIRNR:PIRNR009376};
DE EC=3.1.4.4 {ECO:0000256|PIRNR:PIRNR009376};
OS Amphiprion percula (Orange clownfish) (Lutjanus percula).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Amphiprion.
OX NCBI_TaxID=161767 {ECO:0000313|Ensembl:ENSAPEP00000016470.1, ECO:0000313|Proteomes:UP000265080};
RN [1] {ECO:0000313|Ensembl:ENSAPEP00000016470.1, ECO:0000313|Proteomes:UP000265080}
RP NUCLEOTIDE SEQUENCE.
RA Lehmann R.;
RT "Finding Nemo's genes: A chromosome-scale reference assembly of the genome
RT of the orange clownfish Amphiprion percula.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPEP00000016470.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-
CC sn-glycero-3-phosphate + choline + H(+); Xref=Rhea:RHEA:14445,
CC ChEBI:CHEBI:15354, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:57643, ChEBI:CHEBI:58608; EC=3.1.4.4;
CC Evidence={ECO:0000256|PIRNR:PIRNR009376};
CC -!- SIMILARITY: Belongs to the phospholipase D family.
CC {ECO:0000256|PIRNR:PIRNR009376}.
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DR AlphaFoldDB; A0A3P8SVX4; -.
DR Ensembl; ENSAPET00000016916.1; ENSAPEP00000016470.1; ENSAPEG00000011649.1.
DR GeneTree; ENSGT00940000155015; -.
DR Proteomes; UP000265080; Chromosome 18.
DR GO; GO:0070290; F:N-acylphosphatidylethanolamine-specific phospholipase D activity; IEA:UniProtKB-UniRule.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0004630; F:phospholipase D activity; IEA:UniProtKB-UniRule.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR GO; GO:0006654; P:phosphatidic acid biosynthetic process; IEA:InterPro.
DR CDD; cd01254; PH_PLD; 1.
DR Gene3D; 3.30.870.10; Endonuclease Chain A; 3.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR025202; PLD-like_dom.
DR InterPro; IPR001736; PLipase_D/transphosphatidylase.
DR InterPro; IPR016555; PLipase_D_euk.
DR InterPro; IPR015679; PLipase_D_fam.
DR InterPro; IPR036871; PX_dom_sf.
DR PANTHER; PTHR18896; PHOSPHOLIPASE D; 1.
DR PANTHER; PTHR18896:SF57; PHOSPHOLIPASE D1; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00614; PLDc; 1.
DR Pfam; PF13091; PLDc_2; 1.
DR PIRSF; PIRSF009376; Phospholipase_D_euk; 2.
DR SMART; SM00233; PH; 1.
DR SMART; SM00155; PLDc; 2.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF56024; Phospholipase D/nuclease; 3.
DR SUPFAM; SSF64268; PX domain; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50035; PLD; 2.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PIRNR:PIRNR009376};
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963,
KW ECO:0000256|PIRNR:PIRNR009376};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022963,
KW ECO:0000256|PIRNR:PIRNR009376};
KW Reference proteome {ECO:0000313|Proteomes:UP000265080}.
FT DOMAIN 201..310
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 441..468
FT /note="PLD phosphodiesterase"
FT /evidence="ECO:0000259|PROSITE:PS50035"
FT DOMAIN 825..852
FT /note="PLD phosphodiesterase"
FT /evidence="ECO:0000259|PROSITE:PS50035"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 493..522
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 493..513
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1008 AA; 115610 MW; A27A87A19A66E4C8 CRC64;
MLDKPQPTTS RLDLVNSDFS DATSASDEHD GIDMADLVES LDARELDLGE GEEIDYDGNW
DSRIPFSAVY ATVGFKEANA KVYLPTVPIT ARILEVERFT TAQDRFNLSH HRSIELKHGE
FTWVVKRKEK HFLELHRELR TYKTFMRIPL PSRRLAFAHT QTCTETKNTS LHVHIHTCFC
YIVPMEFIDV SQLSFIHDLG PKGLEGMIHK RSGGHRIPGM NCCGHSQACY RWSKRWLVVK
DSFLLYMKPD SGAISFVLLV DKEFSIKMDS KDTETKHGVR IDSLSRTLVF KCSSYRHARW
WGQSIESFVR SHGKAFLRDH RFGSFAQEQE NIPAKWYVNG KTYMEDVADA LEEAKEEIFI
TDWWLSPEIF LKRPVVEGNR WRLDCILKRK AQQGVRIFVM LYKEVELALG INSGYSKRTL
MHLHPNIKVM RHPDHVSSSV YLWAHHEKIV VIDQSVAFVG GIDLAYGRWD DREHRLTDVG
SVTRSVALEQ VRNTHSVSSA DGVSQSNGRG TPPSEPTDLP KLKGIGRNRM VRFSIYRHLH
KHNLQHVDSV SSVDSAGSGS VRSLKTGVGE LQGNTRFWHG KDYCNFVYKD WIQLEKPFDD
FIDRYTTPRM PWHDIASVVH GRGARDVARH FIQRWNFTKI MKPKYRSLFY PFLLPKSHSG
ANEIRYQVPG CVNAKVQALR SASDWSAGIK YHEESIHTAY IQVIAKSKHY IYIENQFFIS
CADNRTVYNK IGDAIIERVI RAHKEGKKYR VYVVTPLLPG FEGDITTGGG NAIQAVMHFN
YRTMIRGEYS IISQLKKEMD DHWMNYISFA GLRTHAELEG RLVTELIYVH SKMLIADDNT
VIIGSANIND RSMLGKRDSE VAVIVEDSEK VPSVMDGQEY EAGPYALQLR LECFRTILGG
HTDTTIDISD PISDRFYKEV WMTTAGRNAT IYEKVFRCLP SSLVRNMSEL EQYQSKPGLA
QTDLSRAQEE LRKIRGFLVQ FPLDFLSEHN LMPSVGTKEA MVPTEIWT
//
