ID A0A3P8SW95_AMPPE Unreviewed; 586 AA.
AC A0A3P8SW95;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE SubName: Full=Ral GEF with PH domain and SH3 binding motif 2 {ECO:0000313|Ensembl:ENSAPEP00000016352.1};
OS Amphiprion percula (Orange clownfish) (Lutjanus percula).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Amphiprion.
OX NCBI_TaxID=161767 {ECO:0000313|Ensembl:ENSAPEP00000016352.1, ECO:0000313|Proteomes:UP000265080};
RN [1] {ECO:0000313|Ensembl:ENSAPEP00000016352.1, ECO:0000313|Proteomes:UP000265080}
RP NUCLEOTIDE SEQUENCE.
RA Lehmann R.;
RT "Finding Nemo's genes: A chromosome-scale reference assembly of the genome
RT of the orange clownfish Amphiprion percula.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPEP00000016352.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3P8SW95; -.
DR STRING; 161767.ENSAPEP00000016352; -.
DR Ensembl; ENSAPET00000016795.1; ENSAPEP00000016352.1; ENSAPEG00000011622.1.
DR GeneTree; ENSGT00940000154079; -.
DR Proteomes; UP000265080; Chromosome 2.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd13310; PH_RalGPS1_2; 1.
DR CDD; cd00155; RasGEF; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF357; RAS-SPECIFIC GUANINE NUCLEOTIDE-RELEASING FACTOR RALGPS2; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00617; RasGEF; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00147; RasGEF; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000265080}.
FT DOMAIN 51..289
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT DOMAIN 460..572
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 1..32
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 285..307
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 379..404
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..30
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 381..404
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 586 AA; 65419 MW; 29112032ED24ECE4 CRC64;
MMDLPNGQSS ITTNAATISE KSSSSESLSD KGSSELKKSF DAVVFDVLKV TPEEYAGQIT
LMDAPVFKAI QPEELSSCGW NKKEKHSSAP NVVAFTRRFN QTSFWVVREI LHAQTLKIRA
EVLSLYIRTA KKLCDINNLH AVMAVVSGLQ SAPIFRLTKT WALLSRKDKA TFDRLDYLMS
KEDNYKRLRD YISSQSMVSC IPYLGMYLSD LTYIDSAYPS TGSILENEQR SNLMNNLLRI
ISDLQRSCTY DIPVLPHVQK YLNSVRYIEE LQKFVEDDNY KLSQRIEPGT STPRANASKE
DLAGQEASAS PLCGRKCTVA AEGTKVPATP PSPRNLLPYG HRKCHSLGYN FIHKMNTVEF
KSATFPNAGS RHLLDDSVME SHSPTRGQAE SSTLSSGISL GSSEGSELSE EVSWPAFERT
RFYHSLGPVT RVARIPYRGV LRPSSSAESE ELAVHLYPGA VTVQGVLRRK TVLKEGKKPT
VASWTKYWVA LCGTQLYYYP AKSLKATERK HFKSTSSKSV CVVGLMAMMA DDPEHPDVFL
LTDSEHGNTY KYQAGNRMNA LLWFKHLSAA CQSNRQQVPA NLMSFE
//
