ID   A0A3P8SXV4_AMPPE        Unreviewed;       496 AA.
AC   A0A3P8SXV4;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   SubName: Full=Fizzy and cell division cycle 20 related 1 {ECO:0000313|Ensembl:ENSAPEP00000017185.1};
OS   Amphiprion percula (Orange clownfish) (Lutjanus percula).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Pomacentridae; Amphiprion.
OX   NCBI_TaxID=161767 {ECO:0000313|Ensembl:ENSAPEP00000017185.1, ECO:0000313|Proteomes:UP000265080};
RN   [1] {ECO:0000313|Ensembl:ENSAPEP00000017185.1, ECO:0000313|Proteomes:UP000265080}
RP   NUCLEOTIDE SEQUENCE.
RA   Lehmann R.;
RT   "Finding Nemo's genes: A chromosome-scale reference assembly of the genome
RT   of the orange clownfish Amphiprion percula.";
RL   Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSAPEP00000017185.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the WD repeat CDC20/Fizzy family.
CC       {ECO:0000256|ARBA:ARBA00006445}.
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DR   AlphaFoldDB; A0A3P8SXV4; -.
DR   STRING; 161767.ENSAPEP00000017185; -.
DR   Ensembl; ENSAPET00000017673.1; ENSAPEP00000017185.1; ENSAPEG00000012263.1.
DR   GeneTree; ENSGT00950000183104; -.
DR   OMA; FHHEYEK; -.
DR   Proteomes; UP000265080; Chromosome 10.
DR   GO; GO:0010997; F:anaphase-promoting complex binding; IEA:InterPro.
DR   GO; GO:0097027; F:ubiquitin-protein transferase activator activity; IEA:InterPro.
DR   CDD; cd00200; WD40; 1.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR   InterPro; IPR024977; Apc4-like_WD40_dom.
DR   InterPro; IPR033010; Cdc20/Fizzy.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR001680; WD40_rpt.
DR   PANTHER; PTHR19918; CELL DIVISION CYCLE 20 CDC20 FIZZY -RELATED; 1.
DR   PANTHER; PTHR19918:SF34; FIZZY_CELL DIVISION CYCLE 20 RELATED 1 (DROSOPHILA); 1.
DR   Pfam; PF12894; ANAPC4_WD40; 1.
DR   Pfam; PF00400; WD40; 3.
DR   SMART; SM00320; WD40; 6.
DR   SUPFAM; SSF50978; WD40 repeat-like; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 3.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000265080};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW   ProRule:PRU00221}.
FT   REPEAT          228..269
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   DOMAIN          230..284
FT                   /note="Anaphase-promoting complex subunit 4-like WD40"
FT                   /evidence="ECO:0000259|Pfam:PF12894"
FT   REPEAT          312..344
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   REPEAT          442..475
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   REGION          68..88
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          141..169
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        68..84
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        147..165
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   496 AA;  54799 MW;  C51B700734156D08 CRC64;
     MDQDYECRLL RQINIQNENA SPIKAVGVVR SLTPTSSPLS SPSKHGDRFI PSRAGANWSV
     NFHRINEIEK SHNQNRKTKD GTTDSNKADG LAYSALLKNE LLGAGIEKVQ DPQSEDRRLQ
     PSTPAKRSLF SYSVSTKRAL PEEDGNTVSP YSLSPVSSNS QKLLRSPRKP TRKISKIPFK
     VLDAPELQDD FYLNLVDWSS LNVLSVGLGT CVYLWSACTS QVTRLCDLSV EGDSVTSVGW
     SERGNLVAVG THKGYVQIWD AAAGKKLSVL EGHTARVGAL AWNADQLSSG SRDRVILQRD
     IRAPPLQSER RLQGHRQEVC GLKWSTDHQL LASGGNDNKL LVWNHSSVLP VQQYTEHLAA
     VKAIAWSPHQ HGLLASGGGT ADRCIRFWNT LTGQPLQCTD TGSQVCNLAW SKHTNELVST
     HGYSQNQILV WKYPSLTQVA KLTGHSYRVL YLAMSPDGEA IVTGAGDETL RFWNVFSKMR
     STKESVSVLN LFTRIR
//