ID A0A3P8T0Z1_AMPPE Unreviewed; 534 AA.
AC A0A3P8T0Z1;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=Lipoxygenase domain-containing protein {ECO:0000259|PROSITE:PS51393};
OS Amphiprion percula (Orange clownfish) (Lutjanus percula).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Amphiprion.
OX NCBI_TaxID=161767 {ECO:0000313|Ensembl:ENSAPEP00000018296.1, ECO:0000313|Proteomes:UP000265080};
RN [1] {ECO:0000313|Ensembl:ENSAPEP00000018296.1, ECO:0000313|Proteomes:UP000265080}
RP NUCLEOTIDE SEQUENCE.
RA Lehmann R.;
RT "Finding Nemo's genes: A chromosome-scale reference assembly of the genome
RT of the orange clownfish Amphiprion percula.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPEP00000018296.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Fe cation; Xref=ChEBI:CHEBI:24875;
CC Evidence={ECO:0000256|PIRSR:PIRSR601885-1};
CC Note=Binds 1 Fe cation per subunit. {ECO:0000256|PIRSR:PIRSR601885-1};
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DR AlphaFoldDB; A0A3P8T0Z1; -.
DR STRING; 161767.ENSAPEP00000018296; -.
DR Ensembl; ENSAPET00000018805.1; ENSAPEP00000018296.1; ENSAPEG00000013019.1.
DR GeneTree; ENSGT00940000155191; -.
DR Proteomes; UP000265080; Chromosome 15.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0016702; F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen; IEA:InterPro.
DR GO; GO:0034440; P:lipid oxidation; IEA:InterPro.
DR Gene3D; 3.10.450.60; -; 1.
DR InterPro; IPR000907; LipOase.
DR InterPro; IPR013819; LipOase_C.
DR InterPro; IPR036226; LipOase_C_sf.
DR InterPro; IPR001885; LipOase_mml.
DR PANTHER; PTHR11771:SF96; 12-LIPOXYGENASE; 1.
DR PANTHER; PTHR11771; LIPOXYGENASE; 1.
DR Pfam; PF00305; Lipoxygenase; 1.
DR PRINTS; PR00087; LIPOXYGENASE.
DR PRINTS; PR00467; MAMLPOXGNASE.
DR SUPFAM; SSF48484; Lipoxigenase; 1.
DR PROSITE; PS51393; LIPOXYGENASE_3; 1.
PE 4: Predicted;
KW Dioxygenase {ECO:0000256|ARBA:ARBA00022964};
KW Iron {ECO:0000256|PIRSR:PIRSR601885-1};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|PIRSR:PIRSR601885-1};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000265080}.
FT DOMAIN 158..478
FT /note="Lipoxygenase"
FT /evidence="ECO:0000259|PROSITE:PS51393"
FT REGION 1..39
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 304
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PIRSR:PIRSR601885-1"
FT BINDING 471
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PIRSR:PIRSR601885-1"
SQ SEQUENCE 534 AA; 58435 MW; E3D4DF057D09CB16 CRC64;
MLHPALLHPG GRSTSDAASC SAPPGGRPTS DYASWSAPPG GRPTTAAAYC SAKPSSCSTS
PLRGCSTDAA VTCSVSTCPL SGCSTAAASA LLHLSAVPPP LLHSALLHPA AVPLPTATSC
SAPHGGRSTL RCCILVLSTR RPSHHRSLIC LTGFVQAHWK DDWYFGHQCL NGCNPLLLRQ
THILPSNLSV TASMLHPFLP EGSSLQRELQ EGRIYLLDYE VLDGVPANVV NGKQTYLLAP
LCLLHLNQQS QLVPIAIQLQ QNPGPQNPVF LPSDLTSDWL LAKVWVRASD FQCHQLVSYY
LRTHVIGELC CVATLRQLPD LHPLHQTSLQ INLQARTSLL AADGVFDKAM GSGLKTLPVL
LSRASAKTTY RSLCIPDDLK DRGLDNLPQS YYTQDALKVW DALHSFVVSW VNVYDSRDDD
IQLDSELQHW ITDINTHGFT QLRFCFPQSF NTKAEVSKFV TMIIFSCSAL HSAVNFSQVS
QTQAHYRTTT IEIKITTTYQ HVCPCVSIVT MLKTPQILFL CLCMYFSELC SLSW
//
