ID   A0A3P8T1C3_AMPPE        Unreviewed;       778 AA.
AC   A0A3P8T1C3;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   24-JAN-2024, entry version 24.
DE   SubName: Full=Transient receptor potential cation channel subfamily C member 6 {ECO:0000313|Ensembl:ENSAPEP00000017561.1};
OS   Amphiprion percula (Orange clownfish) (Lutjanus percula).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Pomacentridae; Amphiprion.
OX   NCBI_TaxID=161767 {ECO:0000313|Ensembl:ENSAPEP00000017561.1, ECO:0000313|Proteomes:UP000265080};
RN   [1] {ECO:0000313|Ensembl:ENSAPEP00000017561.1, ECO:0000313|Proteomes:UP000265080}
RP   NUCLEOTIDE SEQUENCE.
RA   Lehmann R.;
RT   "Finding Nemo's genes: A chromosome-scale reference assembly of the genome
RT   of the orange clownfish Amphiprion percula.";
RL   Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSAPEP00000017561.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR   AlphaFoldDB; A0A3P8T1C3; -.
DR   Ensembl; ENSAPET00000018057.1; ENSAPEP00000017561.1; ENSAPEG00000012343.1.
DR   GeneTree; ENSGT01060000248588; -.
DR   Proteomes; UP000265080; Chromosome 9.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005262; F:calcium channel activity; IEA:InterPro.
DR   Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR013555; TRP_dom.
DR   InterPro; IPR002153; TRPC_channel.
DR   PANTHER; PTHR10117:SF7; SHORT TRANSIENT RECEPTOR POTENTIAL CHANNEL 6; 1.
DR   PANTHER; PTHR10117; TRANSIENT RECEPTOR POTENTIAL CHANNEL; 1.
DR   Pfam; PF12796; Ank_2; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF08344; TRP_2; 1.
DR   PRINTS; PR01097; TRNSRECEPTRP.
DR   SMART; SM00248; ANK; 2.
DR   SMART; SM01420; TRP_2; 1.
DR   SUPFAM; SSF48403; Ankyrin repeat; 1.
PE   4: Predicted;
KW   ANK repeat {ECO:0000256|ARBA:ARBA00023043};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265080};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   TRANSMEM        320..342
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        408..432
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        515..537
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        557..573
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        585..607
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          187..249
FT                   /note="Transient receptor ion channel"
FT                   /evidence="ECO:0000259|SMART:SM01420"
SQ   SEQUENCE   778 AA;  88876 MW;  870F9AAF03F77743 CRC64;
     MMLRQTAAKP HRQALRGAGY LLHAQSSSCL SLTEELFLEA AEYGNIPEVR RMLEELPGLN
     VNCVNYMGQN ALQLAVANEH LEVTKLLLKK KDLARIGDAL LLAISKGYTR IVEAILSHEA
     FADSRRLTDS PAQAETHDDF FSHDEDGTRF SLDITPIILA SQFHEYEIVH ILFLKGARIE
     RPHDYLCQCM TCSEQQRHDS FSHSQSRINA YKGLASPAYL CLSNEDPVMA ALELSNELAV
     LANTEKEFKN DYKKLSMQCK DFVVGLLDLC RNTEEVEAIL NGDTEACQSS ETCSRQNLIR
     LKLAIKYELK KIGKLMCGPF LKFVAHAASF MIFLCLLVLN AADRFGGTSL LPNMTTHDYP
     SQLFRMKTTP FTWMEILIIS WVIGKIWEEC KGIWSQDFRE YISEPWNLLD FSILTIFMTS
     FIARLMAFWH AYSAQCYIDK HYADLSNKTL PFEIQYFQLA RIHWMPSDPQ LISEGLYAIA
     VVLSFSRIAY ILPANESFGP LQISLGRTVK DIFKFMVVFV TVFVAFMVGM FNLYSYYLGA
     KHNDAFTTYV LEESFKTLFW AIFGLSEVKS VVININHKFI ENIGYVLYGV YNIIMVIVLL
     NMLIAMFNSS FQEIEDDADV EWKFARAKLW FSYFEHGGTL PVPFNLVPSP RSVVSLLLGV
     RESLWDAPSS KSKENSTDEM ELNNVSPLKT QMVRSSLQKI MTCLIKRFIL KAQRDKDNDE
     VNEGELKQIK QDISSLLYEL LERGNHDMRT LGDLVRQLGE DMHVQQKGDK TDEMDILS
//