ID A0A3P8T1W9_AMPPE Unreviewed; 933 AA.
AC A0A3P8T1W9;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=Glutamate receptor {ECO:0000256|RuleBase:RU367118};
GN Name=GRIK4 {ECO:0000313|Ensembl:ENSAPEP00000018626.1};
OS Amphiprion percula (Orange clownfish) (Lutjanus percula).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Amphiprion.
OX NCBI_TaxID=161767 {ECO:0000313|Ensembl:ENSAPEP00000018626.1, ECO:0000313|Proteomes:UP000265080};
RN [1] {ECO:0000313|Ensembl:ENSAPEP00000018626.1, ECO:0000313|Proteomes:UP000265080}
RP NUCLEOTIDE SEQUENCE.
RA Lehmann R.;
RT "Finding Nemo's genes: A chromosome-scale reference assembly of the genome
RT of the orange clownfish Amphiprion percula.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPEP00000018626.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Receptor for glutamate that functions as a ligand-gated ion
CC channel in the central nervous system and plays an important role in
CC excitatory synaptic transmission. L-glutamate acts as an excitatory
CC neurotransmitter at many synapses in the central nervous system.
CC {ECO:0000256|RuleBase:RU367118}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU367118};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU367118}.
CC Postsynaptic cell membrane {ECO:0000256|RuleBase:RU367118}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the glutamate-gated ion channel (TC 1.A.10.1)
CC family. {ECO:0000256|RuleBase:RU367118}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A3P8T1W9; -.
DR STRING; 161767.ENSAPEP00000018626; -.
DR Ensembl; ENSAPET00000019139.1; ENSAPEP00000018626.1; ENSAPEG00000013262.1.
DR GeneTree; ENSGT00940000159111; -.
DR OMA; RMMESRV; -.
DR Proteomes; UP000265080; Chromosome 9.
DR GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015276; F:ligand-gated monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR CDD; cd13724; PBP2_iGluR_kainate_KA1; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 2.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR019594; Glu/Gly-bd.
DR InterPro; IPR001508; Iono_Glu_rcpt_met.
DR InterPro; IPR015683; Ionotropic_Glu_rcpt.
DR InterPro; IPR001320; Iontro_rcpt_C.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR18966:SF171; GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4; 1.
DR PANTHER; PTHR18966; IONOTROPIC GLUTAMATE RECEPTOR; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF00060; Lig_chan; 1.
DR Pfam; PF10613; Lig_chan-Glu_bd; 1.
DR PRINTS; PR00177; NMDARECEPTOR.
DR SMART; SM00918; Lig_chan-Glu_bd; 1.
DR SMART; SM00079; PBPe; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW ECO:0000256|RuleBase:RU367118};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303, ECO:0000256|RuleBase:RU367118};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU367118};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286,
KW ECO:0000256|RuleBase:RU367118};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU367118};
KW Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00023257,
KW ECO:0000256|RuleBase:RU367118};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU367118};
KW Reference proteome {ECO:0000313|Proteomes:UP000265080};
KW Synapse {ECO:0000256|ARBA:ARBA00023018, ECO:0000256|RuleBase:RU367118};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU367118};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU367118};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU367118}.
FT TRANSMEM 513..532
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367118"
FT TRANSMEM 552..571
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367118"
FT TRANSMEM 591..612
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367118"
FT TRANSMEM 771..797
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367118"
FT DOMAIN 383..752
FT /note="Ionotropic glutamate receptor C-terminal"
FT /evidence="ECO:0000259|SMART:SM00079"
FT DOMAIN 393..457
FT /note="Ionotropic glutamate receptor L-glutamate and
FT glycine-binding"
FT /evidence="ECO:0000259|SMART:SM00918"
FT REGION 905..933
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 918..933
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 933 AA; 104679 MW; 9FE2666B4E2223D8 CRC64;
MECSRGERLA ITLAKDSINR NSNRSTTGKL EVDIFELLRD SEYEMGETMC QIMSKGVVAV
LGPSASPASN SIISNICGEK EVPYVKVAPE DILKVQFPRF TTLDLRPTNT DISLAVAGLL
TFFNSTTSCL ICAQAECLLN LEQLLRQFLI SKETLSVRML DDSQDPTPLL KEIRDDKTAT
IIVDANATMS HIILERASEL GMLSVYYTYI FTSLEFSLLR LDDVADQRVN IVGFSVFNKT
HPFFQDFVLS LNRSWQENCD HAPFAGTPLS SALLFDAVYA VVAAVQELNR SQNVGATQLS
CKSSKIWEHG TSLMNYLRMV ELDGLTGHIE FNSKGQRSNY ALRIMQNSKD GLRQIGLWHS
EDGLSMEKKL PSINVTDTLF NTTLTITTIL ENPYVMLRQN HQELEGNDRY EGFCVDMLKE
LADILKFKYR IRLVGDGLYG VPGANGTWTG MVGELISRKA DLAVAGLTIT AEREKVIDFS
KPFMTLGISI MYRVHLGRRP GYFSFLDPFS PGVWLFMLLA YLAVSCVLFL VARLTPYEWY
NPHPCLKGRC NLLINQYSLG NSFWFPVGGF MQQGSTIAPR ALSTRCVSGV WWAFTLIIIS
SYTANLAAFL TVQRMEVPIE SVDDLADQTA IEYGTMHGGS TMTFFQNSRY QTYQRMWNFM
HSKQPSVFVK STEEGIARVL NSNYAYLLES TMNEYYRQRN CNLTQIGGLL DTKGYGIGMP
LGSVYRDEFD LAILKLQEDN RLEILKRKWW DGGKCPKEED HRAKGLGMEN IGGIFVVLVC
GLLVAIFMAV LEFVWMLRQA PGNEQSVCEE MLRELQGIVL CRDSLQVRRR RSASMLRPRP
LPLEERRARA AAVSLSNGKL CGGTGLPEPL SHRLAQEAAL VARGCSHIRI CPECRRFQGL
RMRPAGATGA LPSPTHSEES IEWDKTTNSS EPE
//
