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Database: UniProt
Entry: A0A3P8T2A2_AMPPE
LinkDB: A0A3P8T2A2_AMPPE
Original site: A0A3P8T2A2_AMPPE 
ID   A0A3P8T2A2_AMPPE        Unreviewed;      1414 AA.
AC   A0A3P8T2A2;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   24-JAN-2024, entry version 26.
DE   SubName: Full=Rho guanine nucleotide exchange factor (GEF) 12a {ECO:0000313|Ensembl:ENSAPEP00000018368.1};
GN   Name=ARHGEF12 {ECO:0000313|Ensembl:ENSAPEP00000018368.1};
OS   Amphiprion percula (Orange clownfish) (Lutjanus percula).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Pomacentridae; Amphiprion.
OX   NCBI_TaxID=161767 {ECO:0000313|Ensembl:ENSAPEP00000018368.1, ECO:0000313|Proteomes:UP000265080};
RN   [1] {ECO:0000313|Ensembl:ENSAPEP00000018368.1, ECO:0000313|Proteomes:UP000265080}
RP   NUCLEOTIDE SEQUENCE.
RA   Lehmann R.;
RT   "Finding Nemo's genes: A chromosome-scale reference assembly of the genome
RT   of the orange clownfish Amphiprion percula.";
RL   Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSAPEP00000018368.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC       Membrane {ECO:0000256|ARBA:ARBA00004370}.
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DR   Ensembl; ENSAPET00000018877.1; ENSAPEP00000018368.1; ENSAPEG00000013091.1.
DR   GeneTree; ENSGT00940000157662; -.
DR   OMA; TVSDQRW; -.
DR   Proteomes; UP000265080; Chromosome 9.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd00992; PDZ_signaling; 1.
DR   CDD; cd00160; RhoGEF; 1.
DR   Gene3D; 2.30.42.10; -; 1.
DR   Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH-domain.
DR   InterPro; IPR001331; GDS_CDC24_CS.
DR   InterPro; IPR001478; PDZ.
DR   InterPro; IPR036034; PDZ_sf.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR041020; PH_16.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR015212; RGS-like_dom.
DR   InterPro; IPR036305; RGS_sf.
DR   InterPro; IPR044926; RGS_subdomain_2.
DR   PANTHER; PTHR45872:SF3; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 12; 1.
DR   PANTHER; PTHR45872; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 2, ISOFORM D; 1.
DR   Pfam; PF00595; PDZ; 1.
DR   Pfam; PF17838; PH_16; 1.
DR   Pfam; PF09128; RGS-like; 1.
DR   Pfam; PF00621; RhoGEF; 1.
DR   SMART; SM00228; PDZ; 1.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00325; RhoGEF; 1.
DR   SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR   SUPFAM; SSF50156; PDZ domain-like; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR   PROSITE; PS00741; DH_1; 1.
DR   PROSITE; PS50010; DH_2; 1.
DR   PROSITE; PS50106; PDZ; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265080}.
FT   DOMAIN          54..131
FT                   /note="PDZ"
FT                   /evidence="ECO:0000259|PROSITE:PS50106"
FT   DOMAIN          772..961
FT                   /note="DH"
FT                   /evidence="ECO:0000259|PROSITE:PS50010"
FT   DOMAIN          1003..1116
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   REGION          1..45
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          149..177
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          263..337
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          575..695
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          709..754
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1143..1199
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..19
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        20..39
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        617..686
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        709..726
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1149..1183
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1414 AA;  157728 MW;  8D87006F4F7CB1B5 CRC64;
     MSDTQSSFTD RFPKKANRTS SILSKDHPPD KKPKSDKTSL PSNEFDPTGL VQRCVIIQKD
     ENGFGLTVSG DNPVFVQLVK EDGAAMRAGV QTGDRIIKVN GTLVTHSNHI EVVKLIKSGS
     YVALTVLGRP PGLAQIPLPE AEPEMLGVSI SSPNSPAAER PYSPQDRLSS AHSPWDENSV
     CNQKADILQK MLSKEQQELQ AMKEEYSRNP SPKLLKDIQE AKKHIPQLQG QLFRVTGTTQ
     EAVPGGEADD GSMLETERTF AMKGDNSTDL SWTSSPISRI FGPGSPDSQC PRDSSCPSPK
     STPRNSFNSC HSPETEDTTD LDSLSPTTVS SPSSSRLVSQ IIGAEDDYFD SDQEQTNGQC
     NSFNSIEQLK SRPAHLAAFL HHVISQFDPA PVLCYLYADL YKQTNSKETR RVFMDLHTFF
     IDRGANLKVA VPESVSSDLD RRRTELIPEE INRQHVQTLQ DSLLPDIQRN LEDFRQKRSM
     GLTVAEVELA RLDQERVRDR VTLERERSYA ENIITKIEDI LLTTQTAEEE KCTTMQYVIY
     TYMKHLGVRV KEPRSLESKR VRISFLPKIK KSIKTEKEGE EKVKKPRFPS ILGPQRRPSR
     NEAASVSKAL DGRPRPQKQL SQPTLGASEH METGHLRGSQ SSEGSELTHS MSVNASSPNS
     AFYSTESSRD ADIGGTPTSG PSRLSDGLQS DPLDGFSSHF DLYSLDQLQE DDRESDRAHE
     GTPKAIRRLE GLGAADVQSE DDQGTDSEHD PPNWQQLVGR EVLAGLRPHE IKRQEVINEL
     FYTERAHVRM LKVLDHVFYQ KLSKEAILPP ADIKNIFTNL EEILQLHVSI LEQMAAIRKR
     NESSVIDQIG DDLLSWFGSG EEEKIKQAVG TFCSNQPFAL EIIKTKKKDS RFTSFIQEAE
     SNRLCRRLQL KDLIPIEMQR LTKYPLLLDN IVKYTDNAVE KDKVKQAADC CRKILSHVNQ
     AVKESEDKQR LEDYQRRLDL SSLKQTDNPM ILELKNLDLT KRTMVHEGPL SWKVNKDKTI
     ELYTLLLEDI LVLLQKQDER LILKCHSKNL AGTADTKHIF SPIIKLNTVL VRSVATDNKS
     FFVLSMSDNG AQIYELMAPT VSDQRTWQRL ITQRADAMKV KPHSVIPLPQ TDGERDGVEI
     ITAGVSRLSR DPDRTSTGST QSTDKESGPA CRSALQTSLP GSNPFEGVKA EEEEEEGFVD
     PELPYQVAED GREGDSFSMF PLRADEALKT LAALKQVLVT QLMSQEAAEQ TKRSTGARLL
     RTTSLRTPID SRARVMVHNG SEKNSSQTED LAQDLGSGDT GFFDSPEDYA GYLVLEGYGG
     PGESSTDDDI LASTTGKQLR TSQGCAADSG INLRFSSTSQ AGSLSSFSRQ VLSHLRNLQA
     NLNYLKEVEA KYNNLIHQRP ERSAADTDGN KDKR
//
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