ID A0A3P8T465_AMPPE Unreviewed; 832 AA.
AC A0A3P8T465;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Cadherin 26, tandem duplicate 1 {ECO:0000313|Ensembl:ENSAPEP00000019471.1};
OS Amphiprion percula (Orange clownfish) (Lutjanus percula).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Amphiprion.
OX NCBI_TaxID=161767 {ECO:0000313|Ensembl:ENSAPEP00000019471.1, ECO:0000313|Proteomes:UP000265080};
RN [1] {ECO:0000313|Ensembl:ENSAPEP00000019471.1, ECO:0000313|Proteomes:UP000265080}
RP NUCLEOTIDE SEQUENCE.
RA Lehmann R.;
RT "Finding Nemo's genes: A chromosome-scale reference assembly of the genome
RT of the orange clownfish Amphiprion percula.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPEP00000019471.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Cadherins are calcium-dependent cell adhesion proteins.
CC {ECO:0000256|RuleBase:RU004357}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251,
CC ECO:0000256|RuleBase:RU003318}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004251, ECO:0000256|RuleBase:RU003318}.
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DR AlphaFoldDB; A0A3P8T465; -.
DR STRING; 161767.ENSAPEP00000019471; -.
DR Ensembl; ENSAPET00000019998.1; ENSAPEP00000019471.1; ENSAPEG00000013856.1.
DR GeneTree; ENSGT00940000161589; -.
DR Proteomes; UP000265080; Chromosome 8.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 3.
DR Gene3D; 2.60.40.60; Cadherins; 5.
DR Gene3D; 4.10.900.10; TCF3-CBD (Catenin binding domain); 1.
DR InterPro; IPR039808; Cadherin.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR000233; Cadherin_Y-type_LIR.
DR InterPro; IPR027397; Catenin-bd_sf.
DR PANTHER; PTHR24027; CADHERIN-23; 1.
DR PANTHER; PTHR24027:SF78; CADHERIN-LIKE PROTEIN 26; 1.
DR Pfam; PF01049; CADH_Y-type_LIR; 1.
DR Pfam; PF00028; Cadherin; 3.
DR PRINTS; PR00205; CADHERIN.
DR PRINTS; PR01820; DESMOCOLLIN.
DR SMART; SM00112; CA; 4.
DR SUPFAM; SSF49313; Cadherin-like; 5.
DR PROSITE; PS00232; CADHERIN_1; 2.
DR PROSITE; PS50268; CADHERIN_2; 5.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043};
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003318};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000265080};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003318};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..832
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018245461"
FT TRANSMEM 597..618
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 64..143
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 144..254
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 272..379
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 390..485
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 497..591
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
SQ SEQUENCE 832 AA; 94340 MW; B78B88E00C8D7706 CRC64;
MRIIFLLFLV AFAAPGACHD SEHNRLAKRD VLSRSKRRWV LSTIELEEEK KGDYPMEISR
MFNDKTEGKN FKFKISGEGV DSGIFTIDEK TGIVYAHRAI DRETKDTYHI KFDVVDKVTE
AQIDKELSFD VEIKDINDNA PEFFTSRITA NVNENKEEGY LPVQVQAIDR DQKNTENSRI
SFTVHSQSPK EPKIDVHQLD ERMGQLTFTG CFNYDKAKRY TIIVQAQDHG NPPLSSTCVV
LLNIIDKNTH LPTFKESQYH TQEDEMITKN DILRIKVEDK DTPKTDGWRA KYYFIKGNEE
EIFDITTDPE TNEGIVSIVK KKNYLQTTVL DLQVGVENVE KLFVCQNKST DAKATSAAPT
PNSVSMRVKM IDANDPPDFG RVTFDVYQKE EEMPGKLLYT PQVKDVDSTS IRYELLEDPA
SWVAIDPKTG KLTSTKKMDR ESPFVDEDNI YKVVIAAIDD GEPPATGTCT IKIHLRDIND
NTPKLTNNSL IMCVNKVNKI KVSAKDLDQS PYSGPFAFSL AGDKSVEEQW KLDPNFGMET
GLVSVKALPY GNYSVPFKIL DQQNIVGEDT LEVTVCDCEE GDVCRDKKPR SASFGDAGIG
LLIAGLLLFL ILLLIFMCEC GKKTFEYMEQ DEGNQTLIKY NQEGGGSACK AEPTLLLTPT
NGISVVDGIK QGTMRMTEMA PVMTQEVDRY NTSYTMQMNS NMTSMGMHQR DSFRSHEGQM
VNKYSTWTTN RMNTYQGNSS HYMHSISLRS NQRIADHIDR RLYMIDGMPM DYPVYQPYNY
TYEGQGSKCQ SLDELSVTNL GDDFQFLDDL GPKFKTLGDI CQKKIQEKNI QL
//
