ID A0A3P8T591_AMPPE Unreviewed; 1420 AA.
AC A0A3P8T591;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=receptor protein-tyrosine kinase {ECO:0000256|ARBA:ARBA00011902};
DE EC=2.7.10.1 {ECO:0000256|ARBA:ARBA00011902};
OS Amphiprion percula (Orange clownfish) (Lutjanus percula).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Amphiprion.
OX NCBI_TaxID=161767 {ECO:0000313|Ensembl:ENSAPEP00000018852.1, ECO:0000313|Proteomes:UP000265080};
RN [1] {ECO:0000313|Ensembl:ENSAPEP00000018852.1, ECO:0000313|Proteomes:UP000265080}
RP NUCLEOTIDE SEQUENCE.
RA Lehmann R.;
RT "Finding Nemo's genes: A chromosome-scale reference assembly of the genome
RT of the orange clownfish Amphiprion percula.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPEP00000018852.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001171};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the plexin family.
CC {ECO:0000256|ARBA:ARBA00010297}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00352}.
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DR STRING; 161767.ENSAPEP00000018852; -.
DR Ensembl; ENSAPET00000019367.1; ENSAPEP00000018852.1; ENSAPEG00000013480.1.
DR GeneTree; ENSGT00940000158022; -.
DR OMA; DEEPGQC; -.
DR Proteomes; UP000265080; Chromosome 4.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0007411; P:axon guidance; IEA:UniProt.
DR GO; GO:0021707; P:cerebellar granule cell differentiation; IEA:Ensembl.
DR GO; GO:0021603; P:cranial nerve formation; IEA:Ensembl.
DR GO; GO:0031017; P:exocrine pancreas development; IEA:Ensembl.
DR GO; GO:0001889; P:liver development; IEA:Ensembl.
DR GO; GO:0014812; P:muscle cell migration; IEA:Ensembl.
DR GO; GO:0001764; P:neuron migration; IEA:Ensembl.
DR GO; GO:0033339; P:pectoral fin development; IEA:Ensembl.
DR GO; GO:0021522; P:spinal cord motor neuron differentiation; IEA:Ensembl.
DR GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IEA:InterPro.
DR CDD; cd01179; IPT_plexin_repeat2; 1.
DR CDD; cd05058; PTKc_Met_Ron; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR Gene3D; 3.30.1680.10; ligand-binding face of the semaphorins, domain 2; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR002165; Plexin_repeat.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR016201; PSI.
DR InterPro; IPR001627; Semap_dom.
DR InterPro; IPR036352; Semap_dom_sf.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR008266; Tyr_kinase_AS.
DR InterPro; IPR020635; Tyr_kinase_cat_dom.
DR InterPro; IPR016244; Tyr_kinase_HGF/MSP_rcpt.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR24416:SF483; HEPATOCYTE GROWTH FACTOR RECEPTOR; 1.
DR PANTHER; PTHR24416; TYROSINE-PROTEIN KINASE RECEPTOR; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR Pfam; PF01437; PSI; 1.
DR Pfam; PF01403; Sema; 1.
DR Pfam; PF01833; TIG; 1.
DR PIRSF; PIRSF000617; TyrPK_HGF-R; 1.
DR PRINTS; PR00109; TYRKINASE.
DR SMART; SM00429; IPT; 3.
DR SMART; SM00423; PSI; 1.
DR SMART; SM00220; S_TKc; 1.
DR SMART; SM00630; Sema; 1.
DR SMART; SM00219; TyrKc; 1.
DR SUPFAM; SSF81296; E set domains; 3.
DR SUPFAM; SSF103575; Plexin repeat; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF101912; Sema domain; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
DR PROSITE; PS51004; SEMA; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PIRSR:PIRSR000617-
KW 2};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW ECO:0000256|PIRSR:PIRSR000617-3};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Kinase {ECO:0000256|ARBA:ARBA00023137};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Nucleotide-binding {ECO:0000256|PIRSR:PIRSR000617-2, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000265080};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transferase {ECO:0000256|ARBA:ARBA00023137};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW Tyrosine-protein kinase {ECO:0000256|ARBA:ARBA00023137};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..1420
FT /note="receptor protein-tyrosine kinase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018010119"
FT DOMAIN 24..517
FT /note="Sema"
FT /evidence="ECO:0000259|PROSITE:PS51004"
FT DOMAIN 1092..1355
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT ACT_SITE 1218
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000617-1"
FT BINDING 1098..1106
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR000617-2"
FT BINDING 1124
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR000617-2,
FT ECO:0000256|PROSITE-ProRule:PRU10141"
FT BINDING 1171..1174
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR000617-2"
FT BINDING 1222
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR000617-2"
FT MOD_RES 1248
FT /note="Phosphotyrosine; by autocatalysis"
FT /evidence="ECO:0000256|PIRSR:PIRSR000617-4"
FT MOD_RES 1249
FT /note="Phosphotyrosine; by autocatalysis"
FT /evidence="ECO:0000256|PIRSR:PIRSR000617-4"
FT MOD_RES 1363
FT /note="Phosphotyrosine; by autocatalysis"
FT /evidence="ECO:0000256|PIRSR:PIRSR000617-4"
FT MOD_RES 1370
FT /note="Phosphotyrosine; by autocatalysis"
FT /evidence="ECO:0000256|PIRSR:PIRSR000617-4"
FT DISULFID 124..132
FT /evidence="ECO:0000256|PIRSR:PIRSR000617-3"
FT DISULFID 295..363
FT /evidence="ECO:0000256|PIRSR:PIRSR000617-3"
FT DISULFID 522..540
FT /evidence="ECO:0000256|PIRSR:PIRSR000617-3"
FT DISULFID 528..564
FT /evidence="ECO:0000256|PIRSR:PIRSR000617-3"
FT DISULFID 531..547
FT /evidence="ECO:0000256|PIRSR:PIRSR000617-3"
FT DISULFID 543..553
FT /evidence="ECO:0000256|PIRSR:PIRSR000617-3"
SQ SEQUENCE 1420 AA; 157053 MW; D72C5F77770D82E4 CRC64;
MNLRLLHAIM LLWALCPSVQ GHCDKSSETA KLNLSVTYEL PTFTADFPIQ NMVMLDGIIY
VGAVNRIYAL APNLTKLSEY HTGPLLANET CDQKLTTTGN SGRVDNHNIA LVVENIYDKG
LYSCGSADNG VCRRHVLDDD ISPKTVDEEV SCFADKVRQG RSHISDSDVV VSPSGSQVLN
VESNVIKFFV GNSEIPGPGH ISGNGTHPHT ISVRKMKTSQ NGFTFFSNFS HMDLIPSLHG
NYYLRYVYSF HSGPFTYFLT VQQVSKDSQA YHTRIVRMCS SDLVIRRYIE MPLECISTDK
RRRRSTEDVK VFNILQAAHV TKVGNDVELQ KQLKVEEGDD VLFAAFARGK PNSPEPTANS
AVCVMSLKNI NTLFKMYMQR CNTVDPYHFT GSDRKSCYNV SLSDDCDLHE GIHEGKEGKY
RLQVTQFVQR LEYWHKDLTN TLVTSITVVP VHGRAVAYLG TADGRHIQVL FSRFASPHVN
IRLDSRPVSA SVALLDSGHT NGALLMATGN KITKVPLIGP GCGQLTTCTS CLLSSRVTGC
GWCDGRCTRA NQCPAPSIWT QDYCTPVITK IFPTSGVYTI RGSTAVTVCG RNFGFDKTER
FKASLVTVEV AGAPCKLPRQ DSINRWTEIQ CSPVFSGNFT PSGHTVKVTS GNKVAKMEGF
SFVDPVIHEI FPTFGPKSGN TMLTIRGVFL DAGNKQQVTV GKAVCKIQSL SSTMLTCKTP
PHTVPSEQPV KLTVDSVERH APVLFTYNQD PIINNIQPLR SFVSGGCTVS AHGFFLQSGL
QPQMVLTTGQ DAEVFHVSCV YGENRTSIQC TTPSLAKLAL QPPVVTKVAF VLDGYSTEQW
DLIYVEDPLF QDPKLTSKDN KSIVELKGDR MDREAMKCQV LTVSNHSCES LTLVGNTLEC
TVPTELQAAT AKELQVEWRQ ADSIRHLGKV TLAQEQDYTG LIVGCVCVSL LLLLLGTLLM
WRRNKHIDDL SEVWYDGRGH IQHLDRLANA RSVSPTNEMV SHESVDYRTT LLEDQGTDRP
ETCRGAPPIY GGNGELLSPR LGALGGGMSL MMEGELVSPL LMAPVHIDPS CLHPDLLTEV
QHVVIAREQL LLHLNQVIGR GHFGCVFHGT LLEPDGQKQH CAVKSLNRIT DLEEVSQFLK
EGIIMKDFSH PNVLSLLGIC LPPEGSPLVV LPYMKHGDLR NFIRDEGHNP TVKDLMGFGL
QVARGMDYLA SKKFVHRDLA ARNCMLDESY TVKVADFGLA RDVYDKEYYS VHNKSGVKLP
VKWMALESLQ THKFTTKSDV WSFGVLLWEL MTRGAPPYSD VNSFDITVFL LQGRRLLQPE
FCPDALYTVM IECWHPKPER RPSFSDLVSR ISAIFSSFSG EHYILLNTTY VNIDKMSPYP
SLLASTASSS SSSSSSEPSA STSLPSPSTL FCHVERDCCT
//
