ID A0A3P8T5G0_AMPPE Unreviewed; 914 AA.
AC A0A3P8T5G0;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Espin {ECO:0000313|Ensembl:ENSAPEP00000020550.1};
OS Amphiprion percula (Orange clownfish) (Lutjanus percula).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Amphiprion.
OX NCBI_TaxID=161767 {ECO:0000313|Ensembl:ENSAPEP00000020550.1, ECO:0000313|Proteomes:UP000265080};
RN [1] {ECO:0000313|Ensembl:ENSAPEP00000020550.1, ECO:0000313|Proteomes:UP000265080}
RP NUCLEOTIDE SEQUENCE.
RA Lehmann R.;
RT "Finding Nemo's genes: A chromosome-scale reference assembly of the genome
RT of the orange clownfish Amphiprion percula.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPEP00000020550.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, stereocilium
CC {ECO:0000256|ARBA:ARBA00004645}.
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DR AlphaFoldDB; A0A3P8T5G0; -.
DR Ensembl; ENSAPET00000021099.1; ENSAPEP00000020550.1; ENSAPEG00000014694.1.
DR GeneTree; ENSGT00940000160408; -.
DR OMA; TAHFDIG; -.
DR Proteomes; UP000265080; Chromosome 8.
DR GO; GO:0032420; C:stereocilium; IEA:UniProtKB-SubCell.
DR GO; GO:0003779; F:actin binding; IEA:InterPro.
DR GO; GO:0007605; P:sensory perception of sound; IEA:UniProtKB-KW.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 3.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR003124; WH2_dom.
DR PANTHER; PTHR24153; ESPIN; 1.
DR PANTHER; PTHR24153:SF14; ESPIN ISOFORM X1; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF12796; Ank_2; 3.
DR PRINTS; PR01217; PRICHEXTENSN.
DR SMART; SM00248; ANK; 9.
DR SMART; SM00246; WH2; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 6.
DR PROSITE; PS50088; ANK_REPEAT; 6.
DR PROSITE; PS51082; WH2; 1.
PE 4: Predicted;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Hearing {ECO:0000256|ARBA:ARBA00022740};
KW Reference proteome {ECO:0000313|Proteomes:UP000265080};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT REPEAT 105..129
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 139..171
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 173..195
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 207..229
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 241..273
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 273..305
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 671..688
FT /note="WH2"
FT /evidence="ECO:0000259|PROSITE:PS51082"
FT REGION 337..412
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 434..812
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 853..901
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 824..851
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 350..412
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 449..489
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 497..527
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 528..542
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 584..616
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 617..671
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 689..713
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 714..750
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 751..791
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 853..871
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 874..898
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 914 AA; 96508 MW; B65607667A885369 CRC64;
MVVEGDRTLL AARQGDVQTL KVQLAAKALT SDVKDGLGAS PVHHAARAGK LTCLRFLVEE
AGLPGNCLAN NGANPAHDAA ATGNLACLQW LLTQGGCRPE DRDSSGATVL HLASRFSHHE
ITDWLLKTGE GDPGASTDTG ALPVHYAAAK GDLPSLRLLL GHSPNVVNSQ TKNGATPLYL
ACQEGHLEVV QYLVKDCGAD PSIRANDGMT PLHAAAQMGH NTVIVWLMSF TEISLADRDG
DGATAMHFAA SRGHAKVLSW LLLHGGEIVT DNWGGTPLHD AAENGELECC QILVVNGVDL
AIRDQDGFTA ADLAEYNGHS QCAKYLRTVE NMSVEHRVLS RDPSTELEYK QPDSGLSSPN
TTMPPTSQAA HFNISSPSSS LSNYDSANSS QSSTGEKRSS LTMSRGPPAQ LNTVAHTGAS
ESAISDMQAY MDMLNPDIGS DVPKNTEIPA ESKPPPPPPA YPPPPPPQCP PVPPPPPSYP
APKPPQEPSP AEFLKVKGNL RHVESKKELT SGENHEKLRR VDSNRKSRSF SKQPSTGDYY
KTLGSDTAER RGSKGMAPNE EGSVLLEEPT DSPAHSSENG TTEESVPPPP PPPPPPLPPS
NPMPTPPPPP PLPPETQTAT QNNASSTSSS TQRRPSSSSG SGDMSASQAE GGALRQMKST
KSFNMMSPTG DNSELLAEIK AGKSLKPTPH SKGYTTVFSN SGPTGNNGNS TSPEPPLSSP
PAKPPSPPPS NTSITSPPIT SPPITPSPSP SPTGSGSGSA RTMSTSASYE QLPSNSVING
NSSSGGSAKA ESGRKTSLAD VEALVPTHDE QGKAIPEWKR QVMVRKLQVK MQEEEEHKRK
AEEEAARLAS MPAWRRDMMK KKMDEERCDR SSGGLQLLLS TESAEPAEPS SGTRESPNLL
LLETHLAGKS CRVP
//
