ID A0A3P8T5X3_AMPPE Unreviewed; 1017 AA.
AC A0A3P8T5X3;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=Crumbs cell polarity complex component 2b {ECO:0008006|Google:ProtNLM};
OS Amphiprion percula (Orange clownfish) (Lutjanus percula).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Amphiprion.
OX NCBI_TaxID=161767 {ECO:0000313|Ensembl:ENSAPEP00000020730.1, ECO:0000313|Proteomes:UP000265080};
RN [1] {ECO:0000313|Ensembl:ENSAPEP00000020730.1, ECO:0000313|Proteomes:UP000265080}
RP NUCLEOTIDE SEQUENCE.
RA Lehmann R.;
RT "Finding Nemo's genes: A chromosome-scale reference assembly of the genome
RT of the orange clownfish Amphiprion percula.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPEP00000020730.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A3P8T5X3; -.
DR Ensembl; ENSAPET00000021280.1; ENSAPEP00000020730.1; ENSAPEG00000014566.1.
DR GeneTree; ENSGT00950000183101; -.
DR Proteomes; UP000265080; Chromosome 5.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR CDD; cd00054; EGF_CA; 8.
DR CDD; cd00110; LamG; 3.
DR Gene3D; 2.60.120.200; -; 3.
DR Gene3D; 2.10.25.10; Laminin; 9.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR001791; Laminin_G.
DR PANTHER; PTHR24049; CRUMBS FAMILY MEMBER; 1.
DR PANTHER; PTHR24049:SF22; DROSOPHILA CRUMBS HOMOLOG; 1.
DR Pfam; PF00008; EGF; 7.
DR Pfam; PF12661; hEGF; 1.
DR Pfam; PF02210; Laminin_G_2; 3.
DR PRINTS; PR00010; EGFBLOOD.
DR SMART; SM00181; EGF; 9.
DR SMART; SM00179; EGF_CA; 8.
DR SMART; SM00282; LamG; 3.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 3.
DR SUPFAM; SSF57196; EGF/Laminin; 2.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 4.
DR PROSITE; PS00022; EGF_1; 8.
DR PROSITE; PS01186; EGF_2; 7.
DR PROSITE; PS50026; EGF_3; 9.
DR PROSITE; PS01187; EGF_CA; 2.
DR PROSITE; PS50025; LAM_G_DOMAIN; 3.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000265080};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 952..977
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 30..74
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 76..117
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 121..304
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 306..342
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 344..516
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 518..554
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 582..753
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 755..791
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 793..828
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 830..866
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 870..907
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 909..945
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DISULFID 107..116
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 332..341
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 544..553
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 781..790
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 797..807
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 818..827
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 856..865
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 897..906
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 935..944
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 1017 AA; 112658 MW; F9E2A7AC98FB4DD4 CRC64;
MNTRTYTYCK VKFSYSIKQE KHSDSAVLLN VDECESAPRP CQNGATCEDA ANSYWCHCSP
PEPGQEPWGG RDCDVRLVGC QQHQCQHQAG CVPILTDYGV HSYTCLCPPG WTGERCNTST
TFSFSSEGYI HLQLPVLKNK TKQEMDDYNQ GLHMQLRFRS TLPNMVLYYR GTLERFFSLE
LAEGSLQAKV KSGKVLQAIY AGPVNDGEWH QVTVTMDERL VLTVKGPGCE EGCQVKNEGH
NHLIFLQPSS FQQLYVGGAP QEYLSNLSSR NGFLGCMEDL QVDRKLLLPQ DLIREENKGL
ELGCTKKDWC EDDPCMQHGQ CVDMWVHASC QCHRPYYGQH CEKGSTWTFG HENTTSYSAF
NISETHGDNF TISFLMRSLK HNGLLLQFCR EEKPYLTIYL KEGTVAIYSP HTTLLTEAKL
VTDGNNNLVT IKVNYGHVVF PKAGNHRALG NVSIEAGDVV YVGGLPAGKN MNAWGGHFKG
CLQDIRLDHK HLTTEDHPEG AEVYQASTED NMLLGCKSDN TCKDEPCFNG GQCQVTWNDF
RCDCSIKYSG RLCETRLWCI DKPCFEGVRC VDLQDGYECL TEAIFQDNSL QYVANSSLLS
PVTNITMDLR TRDENGILLR AESRAEVFCL GLLNSSLLVK LDSGAGAELL AFTSDRTIAD
GAWHHIQLTM AEPTQLVSRW RLTVDGQRAG GTFGVSGNLN FLNDTNIWLA EKYTGCLGEV
RVGGVYLPLI NVQEAPQMSR FSRLGGHEPI IGCQGAPICD SQPCLNQGVC QDQFNEFNCS
CSPGWEGELC ETEINECSSA PCVYGTCKDL LADYRCDCEP GYTGKDCKDE VDNCLEFSCV
NGGICLETVG THTCSCPPGY IGKRCQWRFP PVACDANTKC LNGGVCIGAD SGGNCTCKPG
YTGARCETEI DECESSPCLN GATCLDRLNH FQCVCMPGYS GIQCEKEHKE RIPWLAVTIP
LTTLCVLLVI LVVFFLIMTA RKKRQSEGTY SPSSQEVAGA RLEMGSVLKV PPEERLI
//
