ID   A0A3P8T6N8_AMPPE        Unreviewed;       449 AA.
AC   A0A3P8T6N8;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   SubName: Full=Wnt ligand secretion mediator {ECO:0000313|Ensembl:ENSAPEP00000021005.1};
OS   Amphiprion percula (Orange clownfish) (Lutjanus percula).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Pomacentridae; Amphiprion.
OX   NCBI_TaxID=161767 {ECO:0000313|Ensembl:ENSAPEP00000021005.1, ECO:0000313|Proteomes:UP000265080};
RN   [1] {ECO:0000313|Ensembl:ENSAPEP00000021005.1, ECO:0000313|Proteomes:UP000265080}
RP   NUCLEOTIDE SEQUENCE.
RA   Lehmann R.;
RT   "Finding Nemo's genes: A chromosome-scale reference assembly of the genome
RT   of the orange clownfish Amphiprion percula.";
RL   Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSAPEP00000021005.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane
CC       {ECO:0000256|ARBA:ARBA00004439}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004439}. Golgi apparatus membrane
CC       {ECO:0000256|ARBA:ARBA00004653}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004653}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the wntless family.
CC       {ECO:0000256|ARBA:ARBA00008148}.
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DR   AlphaFoldDB; A0A3P8T6N8; -.
DR   Ensembl; ENSAPET00000021562.1; ENSAPEP00000021005.1; ENSAPEG00000014926.1.
DR   GeneTree; ENSGT00390000005897; -.
DR   Proteomes; UP000265080; Chromosome 10.
DR   GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0017147; F:Wnt-protein binding; IEA:InterPro.
DR   GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR   InterPro; IPR047843; WLS-like_TM.
DR   InterPro; IPR009551; Wntless.
DR   PANTHER; PTHR13449; INTEGRAL MEMBRANE PROTEIN GPR177; 1.
DR   PANTHER; PTHR13449:SF2; PROTEIN WNTLESS HOMOLOG; 1.
DR   Pfam; PF06664; MIG-14_Wnt-bd; 1.
PE   3: Inferred from homology;
KW   Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW   Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265080};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius};
KW   Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687}.
FT   TRANSMEM        14..35
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        142..162
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        174..195
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        215..232
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        244..261
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        286..310
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        337..361
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        381..402
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          87..405
FT                   /note="Wntless-like transmembrane"
FT                   /evidence="ECO:0000259|Pfam:PF06664"
SQ   SEQUENCE   449 AA;  51479 MW;  1B46AC26E7C565FB CRC64;
     MAGAIIENMS TKKLVIVGVI LLLFQAFAFM VGGLIEDGAM VTVDVGLAYR DDTISEWTEM
     AHSFEQRKLS CSFTTAKTYE NEGRFYECDL LPFMEVGSVA HKYYLLNIRL PVNDRKKVNV
     GIGEIKDIRL VGIHQNGGFT QVWFAMKTFL TPSILIIMIW YWRRITLMSR PPVLLEKVIL
     ALGISMTFIN IPVEWFSVGF NWTWMLLFGD IRQGIFYSML LSFWIIFCGE HLMDQTERNR
     FSVYWKQVGP IVFGSFCLFI FDMCERGVQL TNPFYSIWAS DVGTELAMAF IIVAGICACL
     YFLFLCFMVF QVFRNISGKR TSLPAMSKAR RLHYEGLIFR FKFLMLVTLT CAAMTVIFFI
     ISQVNEGHWH WGEHTVQVNS AFFTGIYGMW NLYVFAIMFL YAPSHKRYGD EQSSDAGANS
     GEDIQLTTTI THVDGPTEIY KMSGKEAQE
//