ID A0A3P8TB98_AMPPE Unreviewed; 621 AA.
AC A0A3P8TB98;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Fibronectin leucine rich transmembrane protein 2 {ECO:0000313|Ensembl:ENSAPEP00000021804.1};
OS Amphiprion percula (Orange clownfish) (Lutjanus percula).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Amphiprion.
OX NCBI_TaxID=161767 {ECO:0000313|Ensembl:ENSAPEP00000021804.1, ECO:0000313|Proteomes:UP000265080};
RN [1] {ECO:0000313|Ensembl:ENSAPEP00000021804.1, ECO:0000313|Proteomes:UP000265080}
RP NUCLEOTIDE SEQUENCE.
RA Lehmann R.;
RT "Finding Nemo's genes: A chromosome-scale reference assembly of the genome
RT of the orange clownfish Amphiprion percula.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPEP00000021804.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell junction, focal adhesion
CC {ECO:0000256|ARBA:ARBA00004246}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004162}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004162}. Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004586}. Membrane
CC {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004167}. Secreted
CC {ECO:0000256|ARBA:ARBA00004613}.
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DR AlphaFoldDB; A0A3P8TB98; -.
DR STRING; 161767.ENSAPEP00000021804; -.
DR Ensembl; ENSAPET00000022385.1; ENSAPEP00000021804.1; ENSAPEG00000015545.1.
DR GeneTree; ENSGT00940000158937; -.
DR OMA; YRICVHV; -.
DR Proteomes; UP000265080; Chromosome 11.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005925; C:focal adhesion; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR CDD; cd00063; FN3; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000372; LRRNT.
DR PANTHER; PTHR45712; AGAP008170-PA; 1.
DR PANTHER; PTHR45712:SF16; LEUCINE-RICH REPEAT TRANSMEMBRANE PROTEIN FLRT2; 1.
DR Pfam; PF00041; fn3; 1.
DR Pfam; PF13855; LRR_8; 3.
DR SMART; SM00369; LRR_TYP; 8.
DR SMART; SM00082; LRRCT; 1.
DR SMART; SM00013; LRRNT; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR SUPFAM; SSF52058; L domain-like; 2.
DR PROSITE; PS50853; FN3; 1.
PE 4: Predicted;
KW Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000265080};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..35
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 36..621
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018287732"
FT TRANSMEM 500..523
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 383..480
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 470..493
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 621 AA; 69516 MW; 5F5183EC0425B639 CRC64;
MEFLAGPWNK DWASFLQFWL TVILSLQMQF SPGASCPEEC RCDKSFVYCN ERSLTSVPLG
MQEGYKVLYL HNNQINNAGF PVELHNLASV ETVVLYGNQL DEFPVNLPKN TRVLHLQENN
IQTISRAALA QLTQLEELHL DDNSISTVGV EEGAFREAVS LKLLFLTKNH LSSVPIGLPE
DLKELRLDEN RIAVIAEEAF QNVTRLQRLL LDGNLLTDEG IAPGTFQDLA TLRELALARN
SLTFPPPLLP SQSLVKLSLQ ENQIDQIPVA AFAGLNRLEK LDISNNQLQT LTQGVFDGLS
SLKHLIVRNN PWRCDCAVKW VVVWLKSLPS SINARGFVCS SPEKVRGMTI RELTLDIIEC
PVHPDQPPWP TLRSTPPPPP TTTPDPLQIS FHVVNSTSIE VSWASYFTVT AYKVTWVKRG
QSQINEGMRE RTVSGDRRHV SLTNLEPRSV YRICVHVLDT LNSYRPGEDT VCSEARTKAP
ASTKPPGREQ APQDSINSTL LMAGIIGGAV LIILVTLLGL FCWHMHRKSR SSSTKWKYNR
GRRKDDYCEA GTKKDNSILE MTETSFQIVA LNNEQLLKGD FRIQPIYTPN GGIGFRDCHL
SNNSIAYCKS SNVPSTEFCH T
//
