ID   A0A3P8TC26_AMPPE        Unreviewed;       429 AA.
AC   A0A3P8TC26;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 20.
DE   RecName: Full=Growth/differentiation factor 10 {ECO:0000256|ARBA:ARBA00040122};
DE   AltName: Full=Bone morphogenetic protein 3B {ECO:0000256|ARBA:ARBA00042879};
GN   Name=GDF10 {ECO:0000313|Ensembl:ENSAPEP00000023055.1};
OS   Amphiprion percula (Orange clownfish) (Lutjanus percula).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Pomacentridae; Amphiprion.
OX   NCBI_TaxID=161767 {ECO:0000313|Ensembl:ENSAPEP00000023055.1, ECO:0000313|Proteomes:UP000265080};
RN   [1] {ECO:0000313|Ensembl:ENSAPEP00000023055.1, ECO:0000313|Proteomes:UP000265080}
RP   NUCLEOTIDE SEQUENCE.
RA   Lehmann R.;
RT   "Finding Nemo's genes: A chromosome-scale reference assembly of the genome
RT   of the orange clownfish Amphiprion percula.";
RL   Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSAPEP00000023055.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC   -!- SIMILARITY: Belongs to the TGF-beta family.
CC       {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
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DR   AlphaFoldDB; A0A3P8TC26; -.
DR   Ensembl; ENSAPET00000023665.1; ENSAPEP00000023055.1; ENSAPEG00000016236.1.
DR   GeneTree; ENSGT00940000157214; -.
DR   Proteomes; UP000265080; Chromosome 20.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR001839; TGF-b_C.
DR   InterPro; IPR015615; TGF-beta-rel.
DR   InterPro; IPR017948; TGFb_CS.
DR   PANTHER; PTHR11848:SF145; GROWTH_DIFFERENTIATION FACTOR 10; 1.
DR   PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR   Pfam; PF00019; TGF_beta; 1.
DR   PRINTS; PR00669; INHIBINA.
DR   SMART; SM00204; TGFB; 1.
DR   SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR   PROSITE; PS00250; TGF_BETA_1; 1.
DR   PROSITE; PS51362; TGF_BETA_2; 1.
PE   3: Inferred from homology;
KW   Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW   ECO:0000256|RuleBase:RU000354};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265080};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           21..429
FT                   /note="Growth/differentiation factor 10"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5018076782"
FT   DOMAIN          314..429
FT                   /note="TGF-beta family profile"
FT                   /evidence="ECO:0000259|PROSITE:PS51362"
SQ   SEQUENCE   429 AA;  48894 MW;  02005CCDF2AFDB8C CRC64;
     MAVLSMISSH LLLRFHQSSS DPDDLDQDMV YQHMHRLYEK YNKENRLKEG NTVRSFKASQ
     ESSDRRMMYR LNLTTLQDSE VILSATFHFL LDKHSHHKPW FCKRFKSPSC RSSDIHPSPS
     VSLLLRSVSS GSEVRSGSMG SFLGNVTFHP HRRGVWQMKD VTQVIKEARD KGHLLVSVEL
     DLRKQYQKKP EETLSAGSMP YLLLYANDQA LAEPNGVAAS LQRYDPFSEG GDTSHSSQLK
     GRVRREANLH SDPIQNNELP EVDYRPDGYR KDDLWESTWY LALKNEGKDG KKHKGSVNAQ
     SPVLSFDEQT MRKARRRQWS SNQHRGCSRR NLRVDFADIG WSEWVIAPKA YEAYYCAGTC
     GFPMPKVTRP SNHATIQSIV RAVGIIPGVP EPCCVPESMS PLAVLYQDES RNPVLKIYPN
     MSVQSCSCR
//