ID A0A3P8TCJ0_AMPPE Unreviewed; 2416 AA.
AC A0A3P8TCJ0;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Nuclear receptor corepressor 1 {ECO:0000256|ARBA:ARBA00044171};
OS Amphiprion percula (Orange clownfish) (Lutjanus percula).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Amphiprion.
OX NCBI_TaxID=161767 {ECO:0000313|Ensembl:ENSAPEP00000022356.1, ECO:0000313|Proteomes:UP000265080};
RN [1] {ECO:0000313|Ensembl:ENSAPEP00000022356.1, ECO:0000313|Proteomes:UP000265080}
RP NUCLEOTIDE SEQUENCE.
RA Lehmann R.;
RT "Finding Nemo's genes: A chromosome-scale reference assembly of the genome
RT of the orange clownfish Amphiprion percula.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPEP00000022356.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the N-CoR nuclear receptor corepressors family.
CC {ECO:0000256|ARBA:ARBA00010097}.
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DR STRING; 161767.ENSAPEP00000022356; -.
DR Ensembl; ENSAPET00000022935.1; ENSAPEP00000022356.1; ENSAPEG00000015934.1.
DR GeneTree; ENSGT00940000155093; -.
DR Proteomes; UP000265080; Chromosome 15.
DR GO; GO:0005634; C:nucleus; IEA:UniProt.
DR CDD; cd00167; SANT; 2.
DR Gene3D; 1.20.5.430; -; 1.
DR Gene3D; 1.20.58.1880; -; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017930; Myb_dom.
DR InterPro; IPR031557; N-CoR_GPS2_interact.
DR InterPro; IPR001005; SANT/Myb.
DR InterPro; IPR017884; SANT_dom.
DR PANTHER; PTHR13992; NUCLEAR RECEPTOR CO-REPRESSOR RELATED NCOR; 1.
DR PANTHER; PTHR13992:SF5; NUCLEAR RECEPTOR COREPRESSOR 1; 1.
DR Pfam; PF15784; GPS2_interact; 1.
DR Pfam; PF00249; Myb_DNA-binding; 2.
DR SMART; SM00717; SANT; 2.
DR SUPFAM; SSF46689; Homeodomain-like; 2.
DR PROSITE; PS51294; HTH_MYB; 1.
DR PROSITE; PS50090; MYB_LIKE; 1.
DR PROSITE; PS51293; SANT; 2.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Reference proteome {ECO:0000313|Proteomes:UP000265080};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 445..496
FT /note="SANT"
FT /evidence="ECO:0000259|PROSITE:PS51293"
FT DOMAIN 659..709
FT /note="Myb-like"
FT /evidence="ECO:0000259|PROSITE:PS50090"
FT DOMAIN 662..713
FT /note="SANT"
FT /evidence="ECO:0000259|PROSITE:PS51293"
FT DOMAIN 666..713
FT /note="HTH myb-type"
FT /evidence="ECO:0000259|PROSITE:PS51294"
FT REGION 1..76
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 141..170
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 203..222
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 501..680
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 716..926
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 969..1007
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1023..1056
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1078..1167
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1246..1278
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1438..1545
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1671..1783
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1830..2036
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2051..2175
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2259..2396
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 311..338
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..43
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 514..580
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 581..604
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 616..630
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 664..680
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 716..733
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 741..758
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 759..775
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 783..805
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 845..883
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 970..986
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1086..1101
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1103..1122
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1247..1271
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1440..1489
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1699..1752
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1839..1855
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1903..1919
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1948..1964
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1974..1989
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2008..2036
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2051..2107
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2108..2125
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2273..2312
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2321..2396
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2416 AA; 267386 MW; EFACE939B99C7709 CRC64;
MSSSSGYPPS QGSFSSEQSR YPPHSVQYTF TGTRHQQDFT IPDYRTHMQD PQGRRRPSLL
SEFHPGTERP PERRHGYEQQ FHSITAQPEH EALEAKRPRM ETVAEAHITR TPSTAGGIIL
PMPHSVQDSL RATVEVKKES QFAVKVESPS PGGPSLHMGE EQDTSPSKLS KEELIQSMDR
VDREIAKVEQ QIFKLKKKQQ QLEEEAAKPV EPEKPVTPPP VEHKHRSIVQ IIYDENRKKA
EEAHKILEGL GPKVELPLYN QPSDTKVYHD NIKTNQVMRK KLILFFKRRN HARKQRTLIC
QRSDSTQMTS ADQEQKICQR YDQLMEAWEK KVERMENNPR RKAKESRTRE YYERQFPEIR
KQREQQERFQ RVGQRGTGLS ATIARSEHEI SEIIDGLSEQ ENNEKQMRQL SVIPPMMYDS
EQRRVKFINM NGLMDDPMKV YKSRQFMNVW TEHEKEIFKE KFVQHPKNFG LIASYLERKC
VADCVLYYYL TKKNHNYKTL VRRNYGRRRG RNQQITRPSQ EDKSDDKNEE DKSEKSEKKE
DEEKKDEEEK DEKEDSRDIG KDKEKCDGGE DEDGKEQNTP RGRKTANSQG RRKGRITTRS
MANEAASVAA EEGPPTAPEP ALPDPPQLPK SDPAQKAMKE PVKPQTPVAS MDANKAGAGE
TGETSRWTEE EMEVAKKGLV EHGRNWTAIA KMVGTKSEAQ CKNFYFNYKR RHNLDNLLQQ
HKQDSRRARA DRSQAEGLAT ASPDDDEDNA DDSEGGDNSS DTESAPSPSQ AESTKSGDSK
RADSTAGDAQ CSDQDRGQTS NGKAPEPSYG GLCVKQEKSP ESEAGSQEEK ARVASFAGSV
HPKTEPQDVD MKTGEVQVKM EPEIKEKGEK GDHGERQREL HSDNDSSATC SADEDVEAEP
ERQRIFTMEK PSLLSPPGSV LVSSPKQAQL NIQQLHQRAA AIPPMVPGPF APSGMPISGF
AMLQHQIKAV HESAHQEEKQ RQNQGDLERR PPFNTRSPTI LERDGKPLPY MPYDMMLALD
QEAHSGQPGS PYRLSPRELS KASPQPDPNA PNASFYSVPP VLHSAANQLV QSMPDGVRVT
FSRPSRPPNI PSPPPLIPTT KPTDKPSFIQ GGSISQGTPG TYLPSHAVYG PEGTKSAAGS
ISLGLPRQQD PNKPGAAVPS IQDGRGNPAK VNEGLAFRSI GSITQGTPAL PQSSIAAELL
GGTITKIATE DLSSPDKARG EQLAKPHVIY EGKIGHILSY DAVKNPRENT RSPRTGHDLK
RTHDMMEGPM ARGHPGREGA PFEGLISRAL PREGLHGDSK ERSLITGSIM QGTPRAAAET
YEDAMKYGKQ IKRESPPIRS YEGGIGKGKP HEGVNTIKEM GRSIHEIPRQ DQSGQDICKT
PDMLDRRVME GSMSQIHSLN QPTIKHNVKS LITSPSKLSH GMPQLEAMER AKYEESKAVR
HTSVVNSTAS VLRSTHQEAS KSQLSPGMYD DTNARRTPVN YSTNPVSRGS PMLGRGPEGG
MSSAKTAAHE RKSAMTPTQR DSVPAKSPVS GGDPVASHSP FDPHHRPVVS GEVYRPHLPP
HLDHSLGFHR VLDPAFMFSR QPSPTGYHTY QLYTMENTRQ TILNDYITSQ QMQVIPRPDI
ARGLSPREQP VAIPYPAGAR GIIDLAQMPP TILLPHPGGT GTPTLERMAY LSGAQPPFPP
RAFNPTSISP GHPTHLAAAA NAERERERER DREQQEKERE KEREREQRER EREREREIRE
RERDRERSNE YIRGGGPEQP VRPGSRGYLH SPSPSLRTQD VVVQQRPSIF QGKSVITSLM
PHSAAVTSAP QSSSRYSTAA DALAALVDAA ASAPQMDVAK VKESKHERDD DMSSSAARRA
PCLSDQQQQE AERRSLHSPY AAMSLPGGKP HPAYSESPGV KDKGPQTKSR IEEELRTHGK
TTITAASFID VIIKRQIADK DTRDRGSQSS DSSSSLSSSR YDNTGGAAIE VISPASSPVQ
TQQDKPEDGQ QQAAAAGMRA YDMSRYRTSG EPPQSSSQQP PSSQSDSYSQ VTKTHRVMTL
ADHISHIITQ DFARNQDPPV SSSASATFQS IGPPVSSSGR VKVPSRYSPE NQAPHHQRPS
SRVSPESGQE KSRSRPGKSP ERGGRPLETY EPISPPQSYQ GMDKQEAGGP PPQRREADNS
EIRSDSRSPG SVSYLPSFFT KLENTSPMVK SKKQEIFRKL NSTSGVGDSD VGNAQPGTEI
FNLPAVTSSS SINPRNHSFS DPANNLGLED IIRKALMGNL EERQEEHQGG VGGVVSNASS
TGSDARQEAT SSPSMGKQKQ GKANSRKSKS PNLGQAYAGG ERPSSVSSVH SEGDYHRQAQ
SQWSWDERPS STGPMQFPYN PLTMRILSNT PPTSIASPSI QSQQQQPPSA GAPVAQQRVW
QSLLSEQYET LSDSDD
//
