ID   A0A3P8TDC5_AMPPE        Unreviewed;      1723 AA.
AC   A0A3P8TDC5;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   RecName: Full=1-phosphatidylinositol 4-kinase {ECO:0000256|ARBA:ARBA00012169};
DE            EC=2.7.1.67 {ECO:0000256|ARBA:ARBA00012169};
OS   Amphiprion percula (Orange clownfish) (Lutjanus percula).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Pomacentridae; Amphiprion.
OX   NCBI_TaxID=161767 {ECO:0000313|Ensembl:ENSAPEP00000023545.1, ECO:0000313|Proteomes:UP000265080};
RN   [1] {ECO:0000313|Ensembl:ENSAPEP00000023545.1, ECO:0000313|Proteomes:UP000265080}
RP   NUCLEOTIDE SEQUENCE.
RA   Lehmann R.;
RT   "Finding Nemo's genes: A chromosome-scale reference assembly of the genome
RT   of the orange clownfish Amphiprion percula.";
RL   Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSAPEP00000023545.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. Type III PI4K
CC       subfamily. {ECO:0000256|ARBA:ARBA00006209}.
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DR   STRING; 161767.ENSAPEP00000023545; -.
DR   Ensembl; ENSAPET00000024173.1; ENSAPEP00000023545.1; ENSAPEG00000016643.1.
DR   GeneTree; ENSGT00550000074798; -.
DR   OMA; MSQRDEN; -.
DR   Proteomes; UP000265080; Chromosome 5.
DR   GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:InterPro.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   CDD; cd05167; PI4Kc_III_alpha; 1.
DR   Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR   Gene3D; 1.25.40.70; Phosphatidylinositol 3-kinase, accessory domain (PIK); 1.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR   InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR   InterPro; IPR018936; PI3/4_kinase_CS.
DR   InterPro; IPR001263; PI3K_accessory_dom.
DR   InterPro; IPR042236; PI3K_accessory_sf.
DR   InterPro; IPR045495; PI4K_N.
DR   InterPro; IPR015433; PI_Kinase.
DR   PANTHER; PTHR10048:SF15; PHOSPHATIDYLINOSITOL 4-KINASE ALPHA; 1.
DR   PANTHER; PTHR10048; PHOSPHATIDYLINOSITOL KINASE; 1.
DR   Pfam; PF00454; PI3_PI4_kinase; 1.
DR   Pfam; PF00613; PI3Ka; 1.
DR   Pfam; PF19274; PI4K_N; 2.
DR   SMART; SM00145; PI3Ka; 1.
DR   SMART; SM00146; PI3Kc; 1.
DR   SUPFAM; SSF48371; ARM repeat; 2.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR   PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR   PROSITE; PS50290; PI3_4_KINASE_3; 1.
DR   PROSITE; PS51545; PIK_HELICAL; 1.
PE   3: Inferred from homology;
KW   Kinase {ECO:0000256|ARBA:ARBA00022777};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265080};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          1158..1347
FT                   /note="PIK helical"
FT                   /evidence="ECO:0000259|PROSITE:PS51545"
FT   DOMAIN          1437..1723
FT                   /note="PI3K/PI4K catalytic"
FT                   /evidence="ECO:0000259|PROSITE:PS50290"
SQ   SEQUENCE   1723 AA;  194936 MW;  87540A74B1E49785 CRC64;
     GHSPCSPTAP GPHYFEALQP TFVREVHDFV LEQFSSSQSE LQRVLHDTGG LPGEQSPLKL
     RCQANAACVD LMVWAVKDEQ GAENLCTKLS EKLQSKTSSK VIIAHMPLLI CCLQGLGRLC
     ERFPVVAHSA TTSLRDFLVV PSPVLVKLYK YHNQYSTGEI RINVTNEHSQ STFNILSNRK
     DQPSMYEQLR DISIDNICRC LKAGLTMDHV IVEAFLASLS NRLYISQEND KDAHLIPDHT
     IRALGHIAVA LRDTPKVMEH ILQILQQKFC QPPSQLDVLI IDQLGCMVIT GNQYIYQEVW
     NLFQQISVKA SSVVYSATKD YRDHGYRHCS LAVINALANI AANLQGEQLV DELMVNLLEL
     FVQLGLEGKR ASERASDKGP ALKASSSAGN LGVLIPVIAV LTRRLPPIKE AKPRLQKLFR
     DFWLYSVVMG FAVEGSGLWP EEWYEGVCEI ATKSPLLTFP SGEPLRSELQ YNSALKNDTV
     TPAELSELRA TISNLLDPPP EGSALINKLD FAMSTYLLSV YRLEYMRMLR SNDPDRFQVM
     FRYFEDKAIQ KDKSGMMQCI ICVGDKVFDV FLQMMAEKPK TKEHEEELER HAQFLLINFN
     HTHKRIRRVA DKYLSGLAET FPHLLWSGRV LKTMLDILQT LSLSLSADIH KDQPYYDIPD
     TPYRITVPDT YEARESIVKD FAARCGEILK EAMKWAPSVT KSHLQEYLNK HQNWVSGLSQ
     HTGLAMATES ILHFAGYNRQ STTLGTTQLT ERPACVKKDY SNFMASLNLR NRYTGEVAGM
     IQFSEATQSQ SDLNKLMILQ MTSALDKKNP EAFTQAMFKM AALLITTKNC DPQLLHHLCW
     SPLKMFTEHG METAIACWEW LLAAHNGVEV PFMREMAGAW QMTVELKMGL FSETKVETGP
     LAVSEESQPA PCAPDVIPHF LWIEFLVQRF EIAKYSSADQ VEIFTAILQR SLSLSVGGAK
     SSLNRHVATF FIILLYSRLL TLGLTLLHAD VVTNATIRNV LREKIYSTAF DYFSITPKFP
     TQTDKRLRED ISIMIKFYAS LQSDKKYLAA NQLVPPVADS RSSLDAAVGQ RQQVAQGWIN
     TYNLSSGMST ISKKSGLSKK SNRGSQLHKY YMKRRTLLLA LLASEIERLT TWYNPLSTQE
     LAIATEQSVE TSIANWRSKY ISLTEKQWKD NVNLAWSIAP YLALQLPARF KNTEAIVSEV
     TRLVRMDPAA VCDVPEAVKF LVTWHTIDAD SPELSHILCW APADPPTGLS YFSSMYPPHP
     LTAQYGVKVL RSFPPVSTHH STPTKSVIVI YLTFMGYVRE YILWAAQKSQ LLAHQFIWNM
     KTNIYLDEEG NQKDPDIGEL LEQMVEEITG SLSGPAKDFY QREFDFFNKI TNVSAIIKPF
     PKGEERKRAC LDAMSQIKVQ PGCYLPSNPE AIVLDIDYKS GTPMQSAAKA PYLAKFKVRR
     CGVSELEKEG LQCRSDSVDE AKNEEEAKRI CWQAAIFKVG DDCRQDMLAL QIISLFKNIF
     QLVGLDLYVF PYRVVATAPG CGVIECIPDC KSRDQLGRQT DFGMYDYFRN QYGDESTLAF
     QKARYNFIRS MAAYSLLLFL LQIKDRHNGN IMLDSQGHLI HIDFGFMFES SPGGNLGWEP
     DIKLTDEMVM IMGGKMEATP FKWFMEMCVR GYLPPIDCTV KMSDIKTNSS DESGPTWMEQ
     RFNPGLSEKD AASFIIKVIQ NCFLSNRSRT YDMIQYYQNQ IPY
//